Marine Metabolites and Metal Ion Chelation

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (1 July 2019) | Viewed by 4993

Special Issue Editor


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Guest Editor
Departamento de Química Fundamental e Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, A Coruna, Spain
Interests: marine natural products; isolation and structural elucidation; organic synthesis; biological activity; medicinal chemistry; bacterial iron uptake; siderophores
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Special Issue Information

Dear Colleagues,

Marine organisms have developed unique mechanisms for the acquisition, sequestration, and utilization of essential trace metals in the marine environment. Many marine secondary metabolites contain functional groups that can complex metals and a great number of marine natural products possess ion chelating ability, such as cyclic peptides, ionophores, siderophores, etc. Studies of isolation, structural elucidation, synthesis and properties of coordination of metal- chelating marine natural products is a topic of increasing interest nowadays due to their potential applications such as agents for medical uses, chelate contrast agents for molecular imaging, bioremediation, metal coordination in surface adhesion, etc. Although some of them may be involved in the uptake and transport of metal ions present in the marine environment, however the real reason of their production is not fully understood. Current investigation is also focused on their structures, dynamics and reactivities and on studies to establish their biological functions. As Guest Editor of this Special Issue of Marine Drugs, I invite you to provide recent advances in all the aspects dealing with marine metabolites and metal ion chelation.

Prof. Dr. Carlos Jimenez
Guest Editor

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Keywords

  • Ion chelating marine natural products
  • Marine metallophores
  • Marine siderophores
  • Marine cyclic peptide–metal complexes
  • Marine metalloenzymes
  • Structural characterization
  • Chemical synthesis
  • Coordination chemistry studies
  • Biosynthetic pathways
  • Biological activity

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Published Papers (1 paper)

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Research

14 pages, 2174 KiB  
Article
Alkaline Phosphatase Immobilization on New Chitosan Membranes with Mg2+ for Biomedical Applications
by Gratiela Teodora Tihan, Roxana Gabriela Zgarian, Elena Berteanu, Daniela Ionita, Georgeta Totea, Catalin Iordachel, Rodica Tatia, Mariana Prodana and Ioana Demetrescu
Mar. Drugs 2018, 16(8), 287; https://doi.org/10.3390/md16080287 - 18 Aug 2018
Cited by 11 | Viewed by 4441
Abstract
In this paper, we present the fabrication and characterization of new chitosan-based membranes while using a new biotechnology for immobilizing alkaline phosphatase (ALP). This technology involved metal ions incorporation to develop new biopolymeric supports. The chemical structure and morphological characteristics of proposed membranes [...] Read more.
In this paper, we present the fabrication and characterization of new chitosan-based membranes while using a new biotechnology for immobilizing alkaline phosphatase (ALP). This technology involved metal ions incorporation to develop new biopolymeric supports. The chemical structure and morphological characteristics of proposed membranes were evaluated by infrared spectroscopy (FT-IR) and the scanning electron microscopy technique (SEM). The inductively coupled plasma mass spectrometry (ICP-MS) evidenced the metal ion release in time. Moreover, the effect of Mg2+ on the enzymatic activity and the antibacterial investigations while using Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria, hemolysis, and biocompatibility behavior were studied. Immobilizing ALP into the chitosan membranes composition followed by the incorporation of Mg2+ led to polymeric supports with enhanced cellular viability when comparing to chitosan-based membranes without Mg2+. The results obtained evidenced promising performance in biomedical applications for the new biopolymeric supports that are based on chitosan, ALP, and metal ions. Full article
(This article belongs to the Special Issue Marine Metabolites and Metal Ion Chelation)
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