Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
5.4
Journals
Marine Drugs
Special Issues
Green Extraction for Obtaining Marine Bioactive Products
share announcement

Green Extraction for Obtaining Marine Bioactive Products

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 8373

Special Issue Editors

Dr. Maria Dolores Torres

E-Mail Website
Guest Editor
Department of Chemical Engineering, Science Faculty (Campus Ourense), Universidade de Vigo, As Lagoas, 32004 Ourense, Spain
Interests: biopolymers; rheology; biorrefinery; hydrogels; bioactive s; seaweeds; green extraction
Dr. Noelia Flórez-Fernández

E-Mail Website
Guest Editor
Department of Chemical Engineering, Science Faculty (Campus Ourense), Universidade de Vigo, As Lagoas, 32004 Ourense, Spain
Interests: seaweeds; green extraction; bioactive compounds; nanoparticles; microparticles; antitumoral; antioxidant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The extraction of bioactive compounds from marine sources is gaining attention in different areas. These bioactive compounds could be obtained from different brown, red and brown sources of macroalgae. In this context, strategies are required which use the novel eco-friendly extraction, fractioning and purification technologies to recover bioactive compounds. The structure, bioactive and biological properties are important to the processing, manufacturing and final application of the bioactive compounds. The development of new applications is also an objective of this study.

This Special Issue aims to provide an overview of recent research advances in green extraction for obtaining marine bioactive products that find an application in fields ranging from food to non-food sectors. As Guest Editors, we cordially invite contributions in the form of original research articles or reviews on this subject.

Dr. Maria Dolores Torres
Dr. Noelia Flórez-Fernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green extraction
  • bioactives
  • macroalgaes
  • biorefinery
  • antioxidants
  • biopolymers
  • biomedical
  • cosmetic
  • encapsulates
  • hydrogels

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 3436 KiB  
Article
Enzyme-Assisted Coextraction of Phenolics and Polysaccharides from Padina gymnospora
by Hoang Chinh Nguyen, Kim Ngan Ngo, Hoai Khang Tran and Colin J. Barrow
Mar. Drugs 2024, 22(1), 42; https://doi.org/10.3390/md22010042 - 12 Jan 2024
Cited by 1 | Viewed by 1454
Abstract
Brown seaweed is a promising source of polysaccharides and phenolics with industrial utility. This work reports the development of a green enzyme-assisted extraction method for simultaneously extracting polysaccharides and phenolics from the brown seaweed Padina gymnospora. Different enzymes (Cellulast, Pectinex, and Alcalase), [...] Read more.
Brown seaweed is a promising source of polysaccharides and phenolics with industrial utility. This work reports the development of a green enzyme-assisted extraction method for simultaneously extracting polysaccharides and phenolics from the brown seaweed Padina gymnospora. Different enzymes (Cellulast, Pectinex, and Alcalase), individually and in combination, were investigated, with Alcalase alone showing the highest efficiency for the simultaneous extraction of polysaccharides and phenolics. Yields from Alcalase-assisted aqueous extraction were higher than those obtained using either water alone or conventional ethanol extraction. Alcalase-assisted extraction was subsequently optimized using a response surface methodology to maximize compound recovery. Maximal polysaccharide and phenolic recovery was obtained under the following extraction conditions: a water-to-sample ratio of 61.31 mL/g, enzyme loading of 0.32%, temperature of 60.5 °C, and extraction time of 1.95 h. The extract was then fractionated to obtain alginate-, fucoidan-, and phenolic-rich fractions. Fractions exhibited potent 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity with IC50 values of 140.55 µg/mL, 126.21 µg/mL, and 48.17 µg/mL, respectively, which were higher than those obtained from conventional extraction methods. The current work shows that bioactive polysaccharides and phenolics can be obtained together in high yield through a single aqueous-only green and efficient Alcalase-assisted extraction. Full article
(This article belongs to the Special Issue Green Extraction for Obtaining Marine Bioactive Products)
►▼ Show Figures

Figure 1

17 pages, 3219 KiB  
Article
Characterization of the Antiproliferative Activity of Sargassum muticum Low and High Molecular Weight Polysaccharide Fractions
by Lara Diego-González, Milena Álvarez-Viñas, Rosana Simón-Vázquez, Herminia Domínguez, Maria Dolores Torres and Noelia Flórez-Fernández
Mar. Drugs 2024, 22(1), 16; https://doi.org/10.3390/md22010016 - 27 Dec 2023
Viewed by 1733
Abstract
The extract obtained by pressurized hot water extraction from Sargassum muticum, to recover the bioactive compound known as fucoidan, was fractionated using membranes of 100, 50, 30, 10, and 5 kDa, obtaining five retentates and the final permeate. These fractions were characterized [...] Read more.
The extract obtained by pressurized hot water extraction from Sargassum muticum, to recover the bioactive compound known as fucoidan, was fractionated using membranes of 100, 50, 30, 10, and 5 kDa, obtaining five retentates and the final permeate. These fractions were characterized for phloroglucinol content, protein content, sulfate content, and trolox equivalent antioxidant capacity (TEAC); apart from oligosaccharides, FTIR and molar mass distribution were also evaluated. Retentates of 100 and 50 kDa showed higher values for phloroglucinol, TEAC, and sulfate content. The rheology of the alginate fraction was also evaluated. Regarding the potential antitumoral activity, all fractions were assessed in MCF-7 cells using a metabolic activity assay based on the reduction of a tetrazolium compound, the most efficient being R100 and R50. Based on the results, these fractions were compared with commercial fucoidans at the same concentrations, and similar results were found. In addition, synergistic cytotoxic effects using two drugs commonly used in breast cancer, cis-Platinum (cis-Pt) and 5-fluorouracil (5-FU), were tested in combination with R100 and R50. Promising results were obtained when the retentate and the drugs were mixed, showing an improvement in the cytotoxicity induced by the chemotherapy. Full article
(This article belongs to the Special Issue Green Extraction for Obtaining Marine Bioactive Products)
►▼ Show Figures

Figure 1

16 pages, 815 KiB  
Article
Bioactivity of Fucoidan-Rich Extracts from Fucus vesiculosus against Rotavirus and Foodborne Pathogens
by Dimitra Graikini, Arturo B. Soro, Saravana P. Sivagnanam, Brijesh K. Tiwari and Lourdes Sánchez
Mar. Drugs 2023, 21(9), 478; https://doi.org/10.3390/md21090478 - 30 Aug 2023
Cited by 3 | Viewed by 1662
Abstract
Marine algae are sources of bioactive components with defensive properties of great value against microbial infections. This study investigated the bioactivity of extracts from brown algae Fucus vesiculosus against rotavirus, the worldwide leading cause of acute gastroenteritis in infants and young children. Moreover, [...] Read more.
Marine algae are sources of bioactive components with defensive properties of great value against microbial infections. This study investigated the bioactivity of extracts from brown algae Fucus vesiculosus against rotavirus, the worldwide leading cause of acute gastroenteritis in infants and young children. Moreover, one of the extracts was tested against four foodborne bacteria: Campylobacter jejuni, Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes, and the non-pathogenic: E. coli K12. In vitro tests using MA104 cells revealed that both whole algae extracts and crude fucoidan precipitates neutralized rotavirus in a dose-responsive manner. The maximum neutralization activity was observed when the rotavirus was incubated with 100 μg mL−1 of the hydrochloric acid-obtained crude fucoidan (91.8%), although crude fucoidan extracted using citric acid also demonstrated high values (89.5%) at the same concentration. Furthermore, molecular weight fractionation of extracts decreased their antirotaviral activity and high molecular weight fractions exhibited higher activity compared to those of lower molecular weight. A seaweed extract with high antirotaviral activity was also found to inhibit the growth of C. jejuni, S. Typhimurium, and L. monocytogenes at a concentration of 0.2 mg mL−1. Overall, this study expands the current knowledge regarding the antimicrobial mechanisms of action of extracts from F. vesiculosus. Full article
(This article belongs to the Special Issue Green Extraction for Obtaining Marine Bioactive Products)
►▼ Show Figures

Graphical abstract

17 pages, 4268 KiB  
Article
Tuning the Bioactive Properties of Dunaliella salina Water Extracts by Ultrasound-Assisted Extraction
by Joana P. A. Ferreira, Madalena Grácio, Isabel Sousa, António Pagarete, M. Cristiana Nunes and Anabela Raymundo
Mar. Drugs 2023, 21(9), 472; https://doi.org/10.3390/md21090472 - 27 Aug 2023
Viewed by 1625
Abstract
(1) Background: Microalgae are promising feedstock for obtaining valuable bioactive compounds. To facilitate the release of these important biomolecules from microalgae, effective cell disruption is usually necessary, where the use of ultrasound has achieved considerable popularity as an alternative to conventional methods. (2) [...] Read more.
(1) Background: Microalgae are promising feedstock for obtaining valuable bioactive compounds. To facilitate the release of these important biomolecules from microalgae, effective cell disruption is usually necessary, where the use of ultrasound has achieved considerable popularity as an alternative to conventional methods. (2) Methods: This paper aims to evaluate the use of ultrasound technology in water medium as a green technology to recover high added-value compounds from Dunaliella salina and improve its sensory profile towards a high level of incorporation into novel food products. (3) Results: Among the variables, the solid concentration and extraction time have the most significant impact on the process. For the extraction of protein, or fat, the most influential factor is the extraction time. Total polyphenols are only significantly affected by the extraction time. The antioxidant capacity is strongly affected by the solid to liquid ratio and, to a small extent, by the extraction time. Ultrasound-assisted extraction improves the overall odor/aroma of D. salina with good acceptability by the panelists. (4) Conclusions: The application of ultrasonic-assisted extraction demonstrates a positive overall effect on enhancing the sensory profile, particularly the odor of microalgal biomass, while the bioactive properties are preserved. Notably, the intense sea/fish odors are reduced, while earthy and citrus notes become more prominent, resulting in an improved overall sensory profile score. This is the first time, to our knowledge, that this innovative, green, and efficient technology has been used to upgrade the aroma profile of microalgae. Full article
(This article belongs to the Special Issue Green Extraction for Obtaining Marine Bioactive Products)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop