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Marine Drugs
Special Issues
Marine Algal Biorefinery for Bioactive Compound Production
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Marine Algal Biorefinery for Bioactive Compound Production

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 4267

Special Issue Editor

Dr. Gilles Bedoux

E-Mail Website
Guest Editor
Laboratoire de Biotechnologie et Chimie Marines, Université Bretagne Sud, Vannes, France
Interests: seaweed; extraction; fractionation; oligosaccharide; analytical chemistry; chromatography; biological activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

Marine algae are a rich source of bioactive compounds. Functional components extracted from algal biomass are widely used for food, feed, fodder, fibre, cosmetics, nutraceutical and pharmaceuticals. These diverse compounds produced under a natural or controlled environment could be used in various industrial domains. The exploration of new compounds with real health effects, together with sustainable biorefinery solutions providing value-added product production, is now an intense field of research.

This Special Issue invites articles and comprehensive reviews with a focus on biorefinery and eco-friendly processes to provide strategies for algal products production, and advanced metabolite fractionation, including the identification of novel bioactive compounds by structural analysis and imaging.

Particular attention will be given to the following innovative track explorations:

  • The impact of growth conditions (including Integrated Multi-Trophic Aquaculture) on the seaweed metabolites;
  • The biorefinery and eco-friendly processes used to provide a strategy for the release of metabolites;
  • The advanced metabolite fractionation, identification of bioactive compounds by structural analysis and imaging, including high-screening content analysis and metabolomics;

Innovative methods for the determination of biological activities, mechanism study and relation between chemical structure and activity.

Dr. Gilles Bedoux
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • seaweed
  • algal bioprocessing
  • bioactive compounds
  • biorefinery
  • eco-extraction
  • fractionation
  • structural analysis
  • biological activity

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Published Papers (3 papers)

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Research

24 pages, 4788 KiB  
Article
Ultrasound Depolymerization and Characterization of Poly- and Oligosaccharides from the Red Alga Solieria chordalis (C. Agardh) J. Agardh 1842
by Mathilde Lesgourgues, Thomas Latire, Nolwenn Terme, Philippe Douzenel, Raphaël Leschiera, Nicolas Lebonvallet, Nathalie Bourgougnon and Gilles Bedoux
Mar. Drugs 2024, 22(8), 367; https://doi.org/10.3390/md22080367 - 13 Aug 2024
Viewed by 391
Abstract
Red seaweed carrageenans are frequently used in industry for its texturizing properties and have demonstrated antiviral activities that can be used in human medicine. However, their high viscosity, high molecular weight, and low skin penetration limit their use. Low-weight carrageenans have a reduced [...] Read more.
Red seaweed carrageenans are frequently used in industry for its texturizing properties and have demonstrated antiviral activities that can be used in human medicine. However, their high viscosity, high molecular weight, and low skin penetration limit their use. Low-weight carrageenans have a reduced viscosity and molecular weight, enhancing their biological properties. In this study, ι-carrageenan from Solieria chordalis, extracted using hot water and dialyzed, was depolymerized using hydrogen peroxide and ultrasound. Ultrasonic depolymerization yielded fractions of average molecular weight (50 kDa) that were rich in sulfate groups (16% and 33%) compared to those from the hydrogen peroxide treatment (7 kDa, 6% and 9%). The potential bioactivity of the polysaccharides and low-molecular-weight (LMW) fractions were assessed using WST-1 and LDH assays for human fibroblast viability, proliferation, and cytotoxicity. The depolymerized fractions did not affect cell proliferation and were not cytotoxic. This research highlights the diversity in the biochemical composition and lack of cytotoxicity of Solieria chordalis polysaccharides and LMW fractions produced by a green (ultrasound) depolymerization method. Full article
(This article belongs to the Special Issue Marine Algal Biorefinery for Bioactive Compound Production)
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17 pages, 2132 KiB  
Article
Quantification of Xylanolytic and Cellulolytic Activities of Fungal Strains Isolated from Palmaria palmata to Enhance R-Phycoerythrin Extraction of Palmaria palmata: From Seaweed to Seaweed
by Yoran Le Strat, Margaux Mandin, Nicolas Ruiz, Thibaut Robiou du Pont, Emilie Ragueneau, Alexandre Barnett, Paul Déléris and Justine Dumay
Mar. Drugs 2023, 21(7), 393; https://doi.org/10.3390/md21070393 - 5 Jul 2023
Cited by 2 | Viewed by 1700
Abstract
R-phycoerythrin (R-PE) can be enzymatically extracted from red seaweeds such as Palmaria palmata. This pigment has numerous applications and is notably known as an antioxidant, antitumoral or anti-inflammatory agent. Enzymes secreted by P. palmata associated fungal strains were assumed to be efficient [...] Read more.
R-phycoerythrin (R-PE) can be enzymatically extracted from red seaweeds such as Palmaria palmata. This pigment has numerous applications and is notably known as an antioxidant, antitumoral or anti-inflammatory agent. Enzymes secreted by P. palmata associated fungal strains were assumed to be efficient and adapted for R-PE extraction from this macroalga. The aim of the present study was to quantify both xylanolytic and cellulolytic activities of enzymatic extracts obtained from six Palmaria palmata derived fungal strains. Degradation of P. palmata biomass by fungal enzymatic extracts was also investigated, focused on soluble protein and R-PE extraction. Enzymatic extracts were obtained by solid state fermentation. Macroalgal degradation abilities were evaluated by measuring reducing sugar release using DNS assays. Soluble proteins and R-PE recovery yields were evaluated through bicinchoninic acid and spectrophotometric assays, respectively. Various enzymatic activities were obtained according to fungal isolates up to 978 U/mL for xylanase and 50 U/mL for cellulase. Enzymatic extract allowed high degrading abilities, with four of the six fungal strains assessed exhibiting at least equal results as the commercial enzymes for the reducing sugar release. Similarly, all six strains allowed the same soluble protein extraction yield and four of them led to an improvement of R-PE extraction. R-PE extraction from P. palamata using marine fungal enzymes appeared particularly promising. To the best of our knowledge, this study is the first on the use of enzymes of P. palmata associated fungi in the degradation of its own biomass for biomolecules recovery. Full article
(This article belongs to the Special Issue Marine Algal Biorefinery for Bioactive Compound Production)
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Graphical abstract

17 pages, 3223 KiB  
Article
Isolation of Mycosporine-like Amino Acids from Red Macroalgae and a Marine Lichen by High-Performance Countercurrent Chromatography: A Strategy to Obtain Biological UV-Filters
by Julia Vega, Daniela Bárcenas-Pérez, David Fuentes-Ríos, Juan Manuel López-Romero, Pavel Hrouzek, Félix López Figueroa and José Cheel
Mar. Drugs 2023, 21(6), 357; https://doi.org/10.3390/md21060357 - 10 Jun 2023
Cited by 4 | Viewed by 1761
Abstract
Marine organisms have gained considerable biotechnological interest in recent years due to their wide variety of bioactive compounds with potential applications. Mycosporine-like amino acids (MAAs) are UV-absorbing secondary metabolites with antioxidant and photoprotective capacity, mainly found in organisms living under stress conditions (e.g., [...] Read more.
Marine organisms have gained considerable biotechnological interest in recent years due to their wide variety of bioactive compounds with potential applications. Mycosporine-like amino acids (MAAs) are UV-absorbing secondary metabolites with antioxidant and photoprotective capacity, mainly found in organisms living under stress conditions (e.g., cyanobacteria, red algae, or lichens). In this work, five MAAs were isolated from two red macroalgae (Pyropia columbina and Gelidium corneum) and one marine lichen (Lichina pygmaea) by high-performance countercurrent chromatography (HPCCC). The selected biphasic solvent system consisted of ethanol, acetonitrile, saturated ammonium sulphate solution, and water (1:1:0.5:1; v:v:v:v). The HPCCC process for P. columbina and G. corneum consisted of eight separation cycles (1 g and 200 mg of extract per cycle, respectively), whereas three cycles were performed for of L. pygmaea (1.2 g extract per cycle). The separation process resulted in fractions enriched with palythine (2.3 mg), asterina-330 (3.3 mg), shinorine (14.8 mg), porphyra-334 (203.5 mg) and mycosporine-serinol (46.6 mg), which were subsequently desalted by using precipitation with methanol and permeation on a Sephadex G-10 column. Target molecules were identified by HPLC, MS, and NMR. Full article
(This article belongs to the Special Issue Marine Algal Biorefinery for Bioactive Compound Production)
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