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Advanced Biomaterials for Early Detection, Drug Delivery, Treatment and Prognosis in Cancer

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 10 October 2024 | Viewed by 2025

Special Issue Editors


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Guest Editor
Assistant Professor, Department of Biochemistry and Molecular Biology at Mayo Clinic Florida, Jacksonville, FL, USA
Interests: biophysics; nanomechanics of nanoparticles; cell–nanoparticle nanomechanical interactions; cell and tissue mechanics in the presence of anticancer drugs; influence of drug delivery on extracellular matrix remodeling

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Guest Editor
Assistant Professor, Department of Biochemistry and Molecular Biology at Mayo Clinic Florida, Jacksonville, FL, USA
Interests: renal cancer; lung cancer; drug resistance; drug delivery systems; liposomes; nanomaterials; nanomedicine; xenograft models
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Special Issue Information

Dear Colleagues,

Cancer remains one of the most difficult pathologies to treat owing to dense stroma, late detection, and resistance to drugs. Several individual treatment modalities and/or combination therapies are proving to be promising, yet there is still no effective therapy exist due to the dynamic nature of this disease. Novel therapeutic interventions for cancer treatments are the need of the hour. The drawbacks of conventional drug delivery include nonspecific targeting, toxicity, reduced efficacy, and a low therapeutic index. Moreover, the lack of real-time prognosis often results in under- or overtreatment, ultimately leading to drug resistance or toxicity, respectively. This Special Issue aims to encourage the design and testing of advanced biomaterials for early detection, drug delivery, treatment, and prognosis that will overcome the limitations of conventional drug therapy. While the focus is on the synthesis and therapeutic/theranostic evaluation of these advanced biomaterials, this multidisciplinary field is extended to incorporate nano- and macroscale biophysical attributes of advanced biomaterials and their interaction with biological components both in vitro and in vivo. Manuscripts with a scientifically sound approach backed with mechanistic insights into therapeutic implications/translational effects are highly encouraged. Review articles covering the present state-of-the-art technologies are also welcomed.

Dr. Tanmay Kulkarni
Dr. Krishnendu Pal
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer
  • nanomaterials
  • advanced microscopy techniques
  • biophysical attributes
  • drug delivery
  • drug resistance
  • combination therapy
  • theranostics

Published Papers (2 papers)

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Research

20 pages, 9311 KiB  
Article
Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
by Ana Nicolao-Gómez, Enrique Martínez-Campos, Lara Moreno, Juan Rodríguez-Hernández and Endzhe Matykina
Materials 2023, 16(24), 7688; https://doi.org/10.3390/ma16247688 - 18 Dec 2023
Cited by 2 | Viewed by 997
Abstract
A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell [...] Read more.
A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell adhesion. The inner, ceramic layer formed by plasma electrolytic oxidation (PEO) has been enriched in bioactive elements (Ca, P, Si). The intermediate PCL layer sealed the defect in the PEO layer and the outer microporous PCL layer loaded with the appropriate active molecule, thus providing drug-eluting capacity. Morphological, chemical, and biological characterizations of the manufactured coatings loaded with ciprofloxacin (CIP) and paracetamol (PAR) have been carried out. In vitro assays with cell lines relevant for cardiovascular implants and bone prosthesis (endothelial cells and premyoblasts) showed that the drug-loaded coating allows for cell proliferation and viability. The study of CIP and PAR cytotoxicity and release rate indicated that the porous PCL layer does not release concentrations detrimental to the cells. However, complete system assays revealed that corrosion behavior and increase of the pH negatively affects cell viability. H2 evolution during corrosion of Mg alloy substrate generates blisters in PCL layer that accelerate the corrosion locally in crevice microenvironment. A detailed mechanism of the system degradation is disclosed. The accelerated degradation of the developed system may present interest for its further adaptation to new cancer therapy strategies. Full article
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12 pages, 2954 KiB  
Article
Rational Design of a Small Molecular Near-Infrared Fluorophore for Improved In Vivo Fluorescence Imaging
by Gayoung Jo, Yoonbin Park, Min Ho Park and Hoon Hyun
Materials 2023, 16(22), 7227; https://doi.org/10.3390/ma16227227 - 18 Nov 2023
Viewed by 711
Abstract
The near-infrared (NIR) fluorescence imaging modality has great potential for application in biomedical imaging research owing to its unique characteristics, such as low tissue autofluorescence and noninvasive visualization with high spatial resolution. Although a variety of NIR fluorophores are continuously reported, the commercially [...] Read more.
The near-infrared (NIR) fluorescence imaging modality has great potential for application in biomedical imaging research owing to its unique characteristics, such as low tissue autofluorescence and noninvasive visualization with high spatial resolution. Although a variety of NIR fluorophores are continuously reported, the commercially available NIR fluorophores are still limited, owing to complex synthetic processes and poor physicochemical properties. To address this issue, a small molecular NIR fluorophore (SMF800) was designed and developed in the present work to improve in vivo target-specific fluorescence imaging. After conjugation with pamidronate (PAM) and bovine serum albumin (BSA), the SMF800 conjugates exhibited successful in vivo targeting in bone and tumor tissues with low background uptake, respectively. The improved in vivo performance of the SMF800 conjugate demonstrated that the small molecular NIR fluorophore SMF800 can be widely used in a much broader range of imaging applications. The structure of SMF800, which was developed by considering two important physicochemical properties, water solubility and conjugatability, is first introduced. Therefore, this work suggests a simple and rational approach to design small, hydrophilic, and conjugatable NIR fluorophores for targeted bioimaging. Full article
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