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Advances in Nanomaterials in Medical Science

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 June 2023) | Viewed by 3238

Special Issue Editor


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Guest Editor
1. Department of Engineering Chemistry, College of Engineering, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
2. Department of Industrial Cosmetic Science, College of Bio-Health University System, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
3. Department of Synchrotron Radiation Science and Technology, College of Bio-Health University System, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
4. LANG SCIENCE Inc., Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
Interests: 2D materials; nanohybrid and nanoporous naterials; layered double hydroxide; battery, electrocatalyst; CO2 capture and conversion; hydrogen production and fuel cell; biomedical and drug delivery system

Special Issue Information

Dear Colleagues,

The development of medical drug delivery and bioimaging systems based on advanced nanomaterials, including nanoparticles, nanopores, and nanocomposite materials, has been one of the most crucial challenges to creating personalized medicine using nanotechnology. Nanomedicine has offered a wide range of innovative biological healthcare strategies, from targeted cancer therapy (chemotherapy, gene therapy, immunotherapy, phototherapy) to dynamic diagnosis, monitoring of disease treatment, and even to vaccination. This Special Issue covers the significance of advanced nanomaterials related to current medical issues, including but not limited to synthesis, characterization, and applications in imaging, diagnostics, improved therapeutics, biomaterials, stem cells and tissue engineering, nanopharmaceutics, nanocosmetics, nanotoxicology, infectious disease, vaccination, antipathogens, etc.

Assoc. Prof. Daehwan Park
Guest Editor

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Keywords

  • nanomedicine
  • nanomaterials
  • drug delivery system
  • diagnosis
  • bio-imaging
  • cancer therapy
  • vaccination
  • biomaterials
  • nanopharmaceutics
  • nanocosmetics

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Published Papers (2 papers)

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Research

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17 pages, 3378 KiB  
Article
Blood Compatibility of Drug–Inorganic Hybrid in Human Blood: Red Blood Cell Hitchhiking and Soft Protein Corona
by Jing Xie, Hyoung-Mi Kim, Kai Kamada and Jae-Min Oh
Materials 2023, 16(19), 6523; https://doi.org/10.3390/ma16196523 - 30 Sep 2023
Cited by 1 | Viewed by 1539
Abstract
A drug-delivery system consisting of an inorganic host—layered double hydroxide (LDH)—and an anticancer drug—methotrexate (MTX)—was prepared via the intercalation route (MTX-LDH), and its hematocompatibility was investigated. Hemolysis, a red blood cell counting assay, and optical microscopy revealed that the MTX-LDH had no harmful [...] Read more.
A drug-delivery system consisting of an inorganic host—layered double hydroxide (LDH)—and an anticancer drug—methotrexate (MTX)—was prepared via the intercalation route (MTX-LDH), and its hematocompatibility was investigated. Hemolysis, a red blood cell counting assay, and optical microscopy revealed that the MTX-LDH had no harmful toxic effect on blood cells. Both scanning electron microscopy and atomic force microscopy exhibited that the MTX-LDH particles softly landed on the concave part inred blood cells without serious morphological changes of the cells. The time-dependent change in the surface charge and hydrodynamic radius of MTX-LDH in the plasma condition demonstrated that the proteins can be gently adsorbed on the MTX-LDH particles, possibly through protein corona, giving rise to good colloidal stability. The fluorescence quenching assay was carried out to monitor the interaction between MTX-LDH and plasma protein, and the result showed that the MTX-LDH had less dynamic interaction with protein compared with MTX alone, due to the capsule moiety of the LDH host. It was verified by a quartz crystal microbalance assay that the surface interaction between MTX-LDH and protein was reversible and reproducible, and the type of protein corona was a soft one, having flexibility toward the biological environment. Full article
(This article belongs to the Special Issue Advances in Nanomaterials in Medical Science)
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Review

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17 pages, 7884 KiB  
Review
Biofunctional Layered Double Hydroxide Nanohybrids for Cancer Therapy
by Joonghak Lee, Hee Seung Seo, Wooram Park, Chun Gwon Park, Yukwon Jeon and Dae-Hwan Park
Materials 2022, 15(22), 7977; https://doi.org/10.3390/ma15227977 - 11 Nov 2022
Cited by 8 | Viewed by 3294
Abstract
Layered double hydroxides (LDHs) with two-dimensional nanostructure are inorganic materials that have attractive advantages such as biocompatibility, facile preparation, and high drug loading capacity for therapeutic bioapplications. Since the intercalation chemistry of DNA molecules into the LDH materials were reported, various LDH nanohybrids [...] Read more.
Layered double hydroxides (LDHs) with two-dimensional nanostructure are inorganic materials that have attractive advantages such as biocompatibility, facile preparation, and high drug loading capacity for therapeutic bioapplications. Since the intercalation chemistry of DNA molecules into the LDH materials were reported, various LDH nanohybrids have been developed for biomedical drug delivery system. For these reasons, LDHs hybridized with numerous therapeutic agents have a significant role in cancer imaging and therapy with targeting functions. In this review, we summarized the recent advances in the preparation of LDH nanohybrids for cancer therapeutic strategies including gene therapy, chemotherapy, immunotherapy, and combination therapy. Full article
(This article belongs to the Special Issue Advances in Nanomaterials in Medical Science)
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