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Carbon/Graphene-Enriched Biomaterials and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 5191

Special Issue Editors

University of G. d'Annunzio Chieti and Pescaradisabled, Chieti, Italy
Interests: stem cells; osteogenic differentiation; biomaterials; anti-cancer drugs; biocompatibility
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Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: inflammation; hyaluronic acid; biomaterials; oxidative stress; tendons
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Graphene has recently emerged as a suitable alternative material for applications in biomedical and regenerative fields.

Graphene is a two-dimensional (2D) carbon-based material with sp2-bonded carbon atoms arranged in a honeycomb lattice structure, with extraordinary electrical, mechanical, physical, and optical properties.

However, graphene has especially great potential in tissue engineering, conservative surgery, and regenerative medicine. Graphene and its derivatives have been widely investigated, since its discovery in 2004, to develop electrical and biomedical devices such as drug delivery systems, biosensors, and regenerative therapies.

The potential applications of graphene in biological systems are numerous and include its use in cell imaging and drug delivery as well as biosensors. Several reports have shown that, when grown on graphene-coated biomaterials, there is an increase of adhesion and proliferation of different cells. Moreover, it is widely recognized that graphene increases cell proliferation, and influences the differentiation of stem cells into certain cell lines. It has been reported that graphene provides a promising biocompatible scaffold that supports the proliferation of human mesenchymal stem cells and accelerates their specific differentiation into several differentiated cell lineages. The differentiation rate is comparable to that achieved with common additives and differentiating factors.

Considering that graphene is an innovative material for functionalizing biomaterials for biomedical applications, to date there is not a comprehensive collection of original scientific papers reporting achievements in this field.

In this context, this Special Issue aims to stimulate the scientific community to spread knowledge regarding the improvement of the performances and functionality of graphene-enriched biomaterials.

Dr. Susi Zara
Dr. Marialucia Gallorini
Guest Editors

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Keywords

  • carbon
  • carbon nanotubes
  • graphene
  • graphene oxide
  • coating
  • functionalization
  • stem cells
  • biomaterials
  • differentiation
  • tissue regeneration
  • tissue engineering

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Published Papers (1 paper)

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Review

16 pages, 8730 KiB  
Review
Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation
by Alessia Ricci, Amelia Cataldi, Susi Zara and Marialucia Gallorini
Materials 2022, 15(6), 2229; https://doi.org/10.3390/ma15062229 - 17 Mar 2022
Cited by 17 | Viewed by 6806
Abstract
Due to its exceptional physical properties, such as high electronic conductivity, good thermal stability, excellent mechanical strength, and chemical versatility, graphene has sparked a lot of interest in the scientific community for various applications. It has therefore been employed as an antibacterial agent, [...] Read more.
Due to its exceptional physical properties, such as high electronic conductivity, good thermal stability, excellent mechanical strength, and chemical versatility, graphene has sparked a lot of interest in the scientific community for various applications. It has therefore been employed as an antibacterial agent, in photothermal therapy (PTT) and biosensors, in gene delivery systems, and in tissue engineering for regenerative purposes. Since it was first discovered in 1947, different graphene derivatives have been synthetized from pristine graphene. The most adaptable derivate is graphene oxide (GO). Owing to different functional groups, the amphiphilic structure of GO can interact with cells and exogenous or endogenous growth/differentiation factors, allowing cell adhesion, growth, and differentiation. When GO is used as a coating for scaffolds and nanomaterials, it has been found to enhance bone, chondrogenic, cardiac, neuronal, and skin regeneration. This review focuses on the applications of graphene-based materials, in particular GO, as a coating for scaffolds in bone and chondrogenic tissue engineering and summarizes the most recent findings. Moreover, novel developments on the immunomodulatory properties of GO are reported. Full article
(This article belongs to the Special Issue Carbon/Graphene-Enriched Biomaterials and Applications)
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