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Hybrid and Composite Biomaterials for Tissue Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 5669

Special Issue Editors


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Guest Editor
Hallym University, Chuncheon, Korea
Interests: 3D bioprinting; bioink; biomaterials; tissue engineering; scaffold imaging; photocrosslinkable hydrogel

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Guest Editor
The Catholic University of Korea, Seoul, Korea
Interests: tissue engineering; design of biomaterials; polymeric nanoparticles; sur-face modification; medical device; biocompatible hydrogels

Special Issue Information

Dear Colleagues,

Biomaterials are very important tissue engineering elements, providing shape and structure for tissue formation, and also delivering bioactive molecules to cells transplanted into biomaterials or the host cells around a transplant. Therefore, it is important to select an appropriate biomaterial to make a high-quality tissue. An ideal biomaterial should possess characteristics such as biocompatibility, biodegradability, and easy processing. Over the past decades, researchers have shown a growing interest in biomaterials for application in a variety of tissue engineering scaffolds.

However, it is difficult for a single biomaterial to have all the properties ideally required to achieve tissue regeneration. Therefore, through the development of hybrid or composite biomaterials, many studies are being conducted to produce materials that exhibit excellent properties of several materials at the same time or exhibit more special properties. Blends or composites of natural and synthetic polymers with diverse other materials has been testified to improve cell-to-cell interaction and facilitate incorporation with host tissues by enhancing the hydrophilicity, degradable properties, and physicochemical and mechanical properties of materials.

This Special Issue aims to introduce new biobased hybrid or composite materials and their applications to improve biomaterial properties for tissue formation, tissue repair, cellular behaviors, and so on. As the guest editors of the Special Issue on these topics, which will be published in the Materials journal (Publisher, MDPI, St Alban-Anlage 66, Basel, Switzerland; IF 2019: 3.057), we would like to invite colleagues who have experience in the regenerative medicine field, especially who are experts in tissue engineering, to participate. We highly recommend submitting papers focused on the topics described by the keywords below, but submissions on related topics that are not mentioned will also be considered.

Dr. Soon Hee Kim
Dr. Dae Hyeok Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biobased blend
  • Hybrid materials
  • Natural polymer
  • Synthetic polymer
  • Biodegradable polymers
  • Nanocellulose-based biocomposites
  • Hydroxyapatite-based biocomposites
  • Polyester-based biocomposites
  • Nanofibrils
  • Nanobiocomposites
  • Biohybrids
  • Multiphase systems
  • 3D bioprinting
  • Tissue engineering
  • Drug delivery
  • Regenerative medicine
  • Scaffold
  • Biomaterials

Published Papers (2 papers)

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Research

21 pages, 8311 KiB  
Article
Impact of Gamma Irradiation on the Properties of Magnesium-Doped Hydroxyapatite in Chitosan Matrix
by Daniela Predoi, Carmen Steluta Ciobanu, Simona Liliana Iconaru, Silviu Adrian Predoi, Mariana Carmen Chifiriuc, Steinar Raaen, Monica Luminita Badea and Krzysztof Rokosz
Materials 2022, 15(15), 5372; https://doi.org/10.3390/ma15155372 - 4 Aug 2022
Cited by 15 | Viewed by 2097
Abstract
This is the first report regarding the effect of gamma irradiation on chitosan-coated magnesium-doped hydroxyapatite (xMg = 0.1; 10 MgHApCh) layers prepared by the spin-coating process. The stability of the resulting 10 MgHApCh gel suspension used to obtain the layers has been [...] Read more.
This is the first report regarding the effect of gamma irradiation on chitosan-coated magnesium-doped hydroxyapatite (xMg = 0.1; 10 MgHApCh) layers prepared by the spin-coating process. The stability of the resulting 10 MgHApCh gel suspension used to obtain the layers has been shown by ultrasound measurements. The presence of magnesium and the effect of the irradiation process on the studied samples were shown by X-ray photoelectron spectroscopy (XPS). The XPS results obtained for irradiated 10 MgHApCh layers suggested that the magnesium and calcium contained in the surface layer are from tricalcium phosphate (TCP; Ca3(PO4)2) and hydroxyapatite (HAp). The XPS analysis has also highlighted that the amount of TCP in the surface layer increased with the irradiation dose. The energy-dispersive X-ray spectroscopy (EDX) evaluation showed that the calcium decreases with the increase in the irradiation dose. In addition, a decrease in crystallinity and crystallite size was highlighted after irradiation. By atomic force microscopy (AFM) we have obtained images suggesting a good homogeneity of the surface of the non-irradiated and irradiated layers. The AFM results were also sustained by the scanning electron microscopy (SEM) images obtained for the studied samples. The effect of gamma-ray doses on the Fourier transform infrared spectroscopy (ATR-FTIR) spectra of 10 MgHApCh composite layers was also evaluated. The in vitro antifungal assays proved that 10 MgHApCh composite layers presented a strong antifungal effect, correlated with the irradiation dose and incubation time. The study of the stability of the 10 MgHApCh gel allowed us to achieve uniform and homogeneous layers that could be used in different biomedical applications. Full article
(This article belongs to the Special Issue Hybrid and Composite Biomaterials for Tissue Engineering)
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19 pages, 89327 KiB  
Article
Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing
by Longhao Jin, Kyeongsoon Park, Yihyun Yoon, Hyeon Soo Kim, Hyeon Ji Kim, Jae Won Choi, Deuk Yong Lee, Heung Jae Chun and Dae Hyeok Yang
Materials 2021, 14(9), 2270; https://doi.org/10.3390/ma14092270 - 27 Apr 2021
Cited by 14 | Viewed by 2791
Abstract
Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) [...] Read more.
Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The 1H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two material types. In addition, ultraviolet–visible (UV–vis) spectroscopy proved an inclusion complex formation between HP-β-CD and TCS, judging by a unique peak observed at 280 cm−1. Furthermore, ColMA/CD-ic-TCS exhibited an interconnected porous structure, controlled release of TCS, good biocompatibility, and antibacterial activity. By in vivo animal testing, we found that ColMA/CD-ic-TCS had a superior wound healing capacity, compared to the other hydrocolloids evaluated, due to synergistic interaction between ColMA and CD-ic-TCS. Together, our findings indicate that ColMA/CD-ic-TCS has a clinical potential as an antibacterial wound dressing. Full article
(This article belongs to the Special Issue Hybrid and Composite Biomaterials for Tissue Engineering)
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