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Influence of Nanomaterials on Biological Processes In Vitro and In Vivo

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 16637

Special Issue Editor

Prof. Dr. Zbigniew Rybak

E-Mail Website
Guest Editor
Pre-Clinical Research Centre, Wroclaw Medical University, Bujwida 44, 50-345 Wrocław, Poland
Interests: biomaterials; vascular stents; biocompatibility; wound healing; biological implants; artificial implants; stem cells; nanomaterials; thin films; scaffolds; bioengineering; medical and dental lasers; laser surface processing; laser decontamination; laser ablation; laser in bone surgery; photobiomodulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoscale structures represent specific characteristics that are not observed in materials in larger scale. The aim of this Special Issue should be covered by papers on application options of nanomaterials in biomedicine based on their nanoscale characteristics. The most advanced research and improvements in use of nanomaterials in biomedicine will be accepted. Studies displaying the effects of nanomaterials on biological processes together with its specific characteristics will also be considered. Special attention will be paid to new methods of nanomaterials use in biomedicine and its potential application in clinical medical procedures.

Topics to be covered in this Special Issue include:

  • Physicochemical properties of nanomaterials
  • Characterization of nanomaterials
  • Application of nanomaterials in biomedicine
  • Modifications of nanomaterials
  • Interactions with lasers and electromagnetic fields
  • Biocompatibility assessment of nanomaterials
  • Biological and medical applications of nanoelectrets

Prof. Dr. Zbigniew Rybak
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoelectrets
  • Nanocomposites
  • Nanolayers
  • Nanoceramics
  • Nanohydroxyapatite
  • Metal ions-doped alloys
  • Material-laser interaction
  • Material-electromagnetic field interaction
  • Nanomaterials biocompatibility
  • Graphene applications
  • Antimicrobial properties

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Published Papers (5 papers)

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Research

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28 pages, 5902 KiB  
Article
Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold
by Julia K. Bar, Tomasz Kowalczyk, Piotr G. Grelewski, Sandra Stamnitz, Maria Paprocka, Joanna Lis, Anna Lis-Nawara, Seongpil An and Aleksandra Klimczak
Materials 2022, 15(5), 1900; https://doi.org/10.3390/ma15051900 - 3 Mar 2022
Cited by 7 | Viewed by 2303
Abstract
Poly(l-lactide-co-caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold. The hDPSCs were seeded [...] Read more.
Poly(l-lactide-co-caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold. The hDPSCs were seeded on PLCL, and their biological features such as viability, proliferation, adhesion, population doubling time, the immunophenotype of hDPSCs and osteogenic differentiation capacity were evaluated on scaffolds. The results showed that the PLCL scaffold significantly supported hDPSC viability/proliferation. The hDPSCs adhesion rate and spreading onto PLCL increased with time of culture. hDPSCs were able to migrate inside the PLCL electrospun scaffold after 7 days of seeding. No differences in morphology and immunophenotype of hDPSCs grown on PLCL and in flasks were observed. The mRNA levels of bone-related genes and their proteins were significantly higher in hDPSCs after osteogenic differentiation on PLCL compared with undifferentiated hDPSCs on PLCL. These results showed that the mechanical properties of a modified PLCL mat provide an appropriate environment that supports hDPSCs attachment, proliferation, migration and their osteogenic differentiation on the PLCL scaffold. The good PLCL biocompatibility with dental pulp stem cells indicates that this mat may be applied in designing a bioactive hDPSCs/PLCL construct for bone tissue engineering. Full article
(This article belongs to the Special Issue Influence of Nanomaterials on Biological Processes In Vitro and In Vivo)
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15 pages, 16391 KiB  
Article
A Study of the Impact of Graphene Oxide on Viral Infection Related to A549 and TC28a2 Human Cell Lines
by Piotr Kuropka, Maciej Dobrzynski, Barbara Bazanow, Dominika Stygar, Tomasz Gebarowski, Anna Leskow, Malgorzata Tarnowska, Katarzyna Szyszka, Malgorzata Malecka, Nicole Nowak, Wieslaw Strek and Rafal J. Wiglusz
Materials 2021, 14(24), 7788; https://doi.org/10.3390/ma14247788 - 16 Dec 2021
Cited by 7 | Viewed by 2639
Abstract
Graphene has been one of the most tested materials since its discovery in 2004. It is known for its special properties, such as electrical conductivity, elasticity and flexibility, antimicrobial effect, and high biocompatibility with many mammal cells. In medicine, the antibacterial, antiviral, and [...] Read more.
Graphene has been one of the most tested materials since its discovery in 2004. It is known for its special properties, such as electrical conductivity, elasticity and flexibility, antimicrobial effect, and high biocompatibility with many mammal cells. In medicine, the antibacterial, antiviral, and antitumor properties of graphene have been tested as intensively as its drug carrying ability. In this study, the protective effect of graphene oxide against Rubella virus infection of human lung epithelial carcinoma cells and human chondrocyte cells was examined. Cells were incubated with graphene oxide alone and in combination with the Rubella virus. The cytopathic effect in two incubation time periods was measured using DAPI dye as a percentage value of the changed cells. It was shown that the graphene oxide alone has no cytopathic effect on any of tested cell lines, while the Rubella virus alone is highly cytopathic to the cells. However, in combination with the graphene oxide percentage of the changed cells, its cytotopathicity is significantly lower. Moreover, it can be concluded that graphene oxide has protective properties against the Rubella virus infection to cells, lowering its cytopathic changes to the human cells. Full article
(This article belongs to the Special Issue Influence of Nanomaterials on Biological Processes In Vitro and In Vivo)
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Graphical abstract

14 pages, 3044 KiB  
Article
In Vitro Assessment of Long-Term Fluoride Ion Release from Nanofluorapatite
by Katarzyna Herman, Marta Wujczyk, Maciej Dobrzynski, Dorota Diakowska, Katarzyna Wiglusz and Rafal J. Wiglusz
Materials 2021, 14(13), 3747; https://doi.org/10.3390/ma14133747 - 4 Jul 2021
Cited by 12 | Viewed by 2415
Abstract
The issue concerning the tooth decay is ongoing, therefore the study of materials with potential use in its prevention is crucial. This study aimed to analyze the long-term release of fluoride from synthesized nanofluorapatite in various in vitro environments for its potential use [...] Read more.
The issue concerning the tooth decay is ongoing, therefore the study of materials with potential use in its prevention is crucial. This study aimed to analyze the long-term release of fluoride from synthesized nanofluorapatite in various in vitro environments for its potential use in dental materials. We placed 100 mg samples in 0.9% NaCl or deionized water and incubated them at 37 °C or 22 °C for 12 weeks. F− levels were read at 1, 3, 24, 48, 72, and 96 h, and thereafter weekly. The levels of F− released at specific time intervals, as well as their cumulative values were compared. In a solution of 0.9% NaCl at 22 °C, there were no significant differences in the amount of F− released in the assessed time intervals, while at 37 °C, the highest value was read after 24 h (0.0697 ppm + 0.0006; p < 0.05). In deionized water, the highest amount of F− at 22 °C was read after 4 weeks (0.0776 ppm + 0.0028; p < 0.05), and at 37 °C, it was also the highest after 4 weeks (0.0910 ppm + 0.0156; p < 0.05). Under the same conditions, after 5 weeks the cumulative level of F− released (0.6216 ppm + 0.0085) significantly increased (p < 0.05), when compared to the samples placed in 0.9% NaCl at 37 °C and 22 °C (0.5493 ppm + 0.0321 and 0.5376 ppm + 0.0234, respectively). FAp releases F− for a long period of time in all assessed environments, therefore it is advised to continue testing in vivo models. Due to the probable remineralization effect towards hard tooth tissues, fluorapatite can be used in the prevention and treatment of dental caries and dentin hypersensitivity. Full article
(This article belongs to the Special Issue Influence of Nanomaterials on Biological Processes In Vitro and In Vivo)
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Review

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19 pages, 383 KiB  
Review
Medical Adhesives and Their Role in Laparoscopic Surgery—A Review of Literature
by Maciej Mazur, Wojciech Zakrzewski, Maria Szymonowicz and Zbigniew Rybak
Materials 2022, 15(15), 5215; https://doi.org/10.3390/ma15155215 - 28 Jul 2022
Cited by 3 | Viewed by 2379
Abstract
Laparoscopic surgery is undergoing rapid development. Replacing the traditional method of joining cut tissues with sutures or staples could greatly simplify and speed up laparoscopic procedures. This alternative could undoubtedly be adhesives. For decades, scientists have been working on a material to bond [...] Read more.
Laparoscopic surgery is undergoing rapid development. Replacing the traditional method of joining cut tissues with sutures or staples could greatly simplify and speed up laparoscopic procedures. This alternative could undoubtedly be adhesives. For decades, scientists have been working on a material to bond tissues together to create the best possible conditions for tissue regeneration. The results of research on tissue adhesives achieved over the past years show comparable treatment effects to traditional methods. Tissue adhesives are a good alternative to surgical sutures in wound closure. This article is a review of the most important groups of tissue adhesives including their properties and possible applications. Recent reports on the development of biological adhesives are also discussed. Full article
(This article belongs to the Special Issue Influence of Nanomaterials on Biological Processes In Vitro and In Vivo)
34 pages, 28256 KiB  
Review
Nanomaterials Application in Endodontics
by Wojciech Zakrzewski, Maciej Dobrzyński, Anna Zawadzka-Knefel, Adam Lubojański, Wojciech Dobrzyński, Mateusz Janecki, Karolina Kurek, Maria Szymonowicz, Rafał Jakub Wiglusz and Zbigniew Rybak
Materials 2021, 14(18), 5296; https://doi.org/10.3390/ma14185296 - 14 Sep 2021
Cited by 17 | Viewed by 5936
Abstract
In recent years, nanomaterials have become increasingly present in medicine, especially in dentistry. Their characteristics are proving to be very useful in clinical cases. Due to the intense research in the field of biomaterials and nanotechnology, the efficacy and possibilities of dental procedures [...] Read more.
In recent years, nanomaterials have become increasingly present in medicine, especially in dentistry. Their characteristics are proving to be very useful in clinical cases. Due to the intense research in the field of biomaterials and nanotechnology, the efficacy and possibilities of dental procedures have immensely expanded over the years. The nano size of materials allows them to exhibit properties not present in their larger-in-scale counterparts. The medical procedures in endodontics are time-consuming and mostly require several visits to be able to achieve the proper result. In this field of dentistry, there are still major issues about the removal of the mostly bacterial infection from the dental root canals. It has been confirmed that nanoparticles are much more efficient than traditional materials and appear to have superior properties when it comes to surface chemistry and bonding. Their unique antibacterial properties are also promising features in every medical procedure, especially in endodontics. High versatility of use of nanomaterials makes them a powerful tool in dental clinics, in a plethora of endodontic procedures, including pulp regeneration, drug delivery, root repair, disinfection, obturation and canal filling. This study focuses on summing up the current knowledge about the utility of nanomaterials in endodontics, their characteristics, advantages, disadvantages, and provides a number of reasons why research in this field should be continued. Full article
(This article belongs to the Special Issue Influence of Nanomaterials on Biological Processes In Vitro and In Vivo)
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