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Novel Antibacterial Materials and Coatings
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Novel Antibacterial Materials and Coatings

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 2804

Special Issue Editors

Dr. Hanif Haidari

E-Mail Website
Guest Editor
Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
Interests: development of antibacterial nanomaterials; treatment of wound infection; preparation of smart hydrogels; targeted drug delivery, nanoparticle synthesis and applications
Prof. Dr. Krasimir Vasilev

E-Mail Website
Guest Editor
Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
Interests: biomaterial developments and applications; surface functionalization; antibacterial coatings; plasma polymers; nanomaterials fabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The surge in antibacterial-resistant infections has severely challenged our ability to provide effective protection and treatment, resulting in increasing global attention toward exploring novel materials. There is an urgent need to develop novel antibacterial materials and coatings to protect, prevent, and improve human health against deadly pathogens currently resistant to most antibiotics. Recently, materials with antibacterial properties have gained more recognition for improving therapeutic outcomes, leading to increased demand for their application in various fields of biomedicine. The possibilities of designing novel materials with tailored properties are endless, offering a myriad of hope to control deadly diseases and improve quality of life. Special attention has been devoted to imparting materials, either new or enhanced properties by surface modification, size optimization, and surface functionalization, or using additives to introduce new functions, all of which provide exciting opportunities to explore and combat the growing threat of antibacterial resistance.

This Special Issue aims to collate an exciting collection of primary research and review articles on areas developing novel antibacterial materials, their fabrication, and applications in various fields, including medicine, agriculture, marine fouling, and food production.

Another aim of this Special Issue is to encourage and stimulate multidisciplinary and collaborative approaches to tackle the fast-growing problem of microbial contamination, infection, and resistance.

It is our pleasure to invite you to submit your work to this Special Issue. Primary research and review papers are welcome in any of the areas mentioned above.

Dr. Hanif Haidari
Prof. Dr. Krasimir Vasilev
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial materials
  • biomaterials
  • hydrogel
  • surface modification
  • antibiotic-resistant infections
  • drug delivery
  • nanomedicine
  • nanomaterials

Published Papers (3 papers)

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Editorial

Jump to: Research

5 pages, 219 KiB  
Editorial
Novel Antibacterial Materials and Coatings—A Perspective by the Editors
by Hanif Haidari and Krasimir Vasilev
Materials 2023, 16(18), 6302; https://doi.org/10.3390/ma16186302 - 20 Sep 2023
Viewed by 858
Abstract
The fight between humans and bacteria has escalated to a new level Full article
(This article belongs to the Special Issue Novel Antibacterial Materials and Coatings)

Research

Jump to: Editorial

15 pages, 3475 KiB  
Article
Hyaluronic Acid/Chondroitin Sulfate-Based Dynamic Thiol–Aldehyde Addition Hydrogel: An Injectable, Self-Healing, On-Demand Dissolution Wound Dressing
by Melissa Johnson, Rijian Song, Yinghao Li, Cameron Milne, Jing Lyu, Irene Lara-Sáez, Sigen A and Wenxin Wang
Materials 2024, 17(12), 3003; https://doi.org/10.3390/ma17123003 - 19 Jun 2024
Viewed by 452
Abstract
Frequent removal and reapplication of wound dressings can cause mechanical disruption to the healing process and significant physical discomfort for patients. In response to this challenge, a dynamic covalent hydrogel has been developed to advance wound care strategies. This system comprises aldehyde functionalized [...] Read more.
Frequent removal and reapplication of wound dressings can cause mechanical disruption to the healing process and significant physical discomfort for patients. In response to this challenge, a dynamic covalent hydrogel has been developed to advance wound care strategies. This system comprises aldehyde functionalized chondroitin sulfate (CS-CHO) and thiolated hyaluronic acid (HA-SH), with the distinct ability to form in situ via thiol–aldehyde addition and dissolve on-demand via the thiol–hemithioacetal exchange reaction. Although rarely reported, the dynamic covalent reaction of thiol–aldehyde addition holds great promise for the preparation of dynamic hydrogels due to its rapid reaction kinetics and easy reversible dissociation. The thiol–aldehyde addition chemistry provides the hydrogel system with highly desirable characteristics of rapid gelation (within seconds), self-healing, and on-demand dissolution (within 30 min). The mechanical and dissolution properties of the hydrogel can be easily tuned by utilizing CS-CHO materials of different aldehyde functional group contents. The chemical structure, rheology, self-healing, swelling profile, degradation rate, and cell biocompatibility of the hydrogels are characterized. The hydrogel possesses excellent biocompatibility and proves to be significant in promoting cell proliferation in vitro when compared to a commercial hydrogel (HyStem® Cell Culture Scaffold Kit). This study introduces the simple fabrication of a new dynamic hydrogel system that can serve as an ideal platform for biomedical applications, particularly in wound care treatments as an on-demand dissolvable wound dressing. Full article
(This article belongs to the Special Issue Novel Antibacterial Materials and Coatings)
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19 pages, 5565 KiB  
Article
Deferiprone-Gallium-Protoporphyrin Chitogel Decreases Pseudomonas aeruginosa Biofilm Infection without Impairing Wound Healing
by Tahlia L. Kennewell, Hanif Haidari, Suzanne Mashtoub, Gordon S. Howarth, Catherine Bennett, Clare M. Cooksley, Peter John Wormald, Allison J. Cowin, Sarah Vreugde and Zlatko Kopecki
Materials 2024, 17(4), 793; https://doi.org/10.3390/ma17040793 - 7 Feb 2024
Cited by 1 | Viewed by 967
Abstract
Pseudomonas aeruginosa is one of the most common pathogens encountered in clinical wound infections. Clinical studies have shown that P. aeruginosa infection results in a larger wound area, inhibiting healing, and a high prevalence of antimicrobial resistance. Hydroxypyridinone-derived iron chelator Deferiprone (Def) and [...] Read more.
Pseudomonas aeruginosa is one of the most common pathogens encountered in clinical wound infections. Clinical studies have shown that P. aeruginosa infection results in a larger wound area, inhibiting healing, and a high prevalence of antimicrobial resistance. Hydroxypyridinone-derived iron chelator Deferiprone (Def) and heme analogue Gallium-Protoporphyrin (GaPP) in a chitosan-dextran hydrogel (Chitogel) have previously been demonstrated to be effective against PAO1 and clinical isolates of P. aeruginosa in vitro. Moreover, this combination of these two agents has been shown to improve sinus surgery outcomes by quickly reducing bleeding and preventing adhesions. In this study, the efficacy of Def-GaPP Chitogel was investigated in a P. aeruginosa biofilm-infected wound murine model over 6 days. Two concentrations of Def-GaPP Chitogel were investigated: Def-GaPP high dose (10 mM Def + 500 µg/mL GaPP) and Def-GaPP low dose (5 mM Def + 200 µg/mL GaPP). The high-dose Def-GaPP treatment reduced bacterial burden in vivo from day 2, without delaying wound closure. Additionally, Def-GaPP treatment decreased wound inflammation, as demonstrated by reduced neutrophil infiltration and increased anti-inflammatory M2 macrophage presence within the wound bed to drive wound healing progression. Def-GaPP Chitogel treatment shows promising potential in reducing P. aeruginosa cutaneous infection with positive effects observed in the progression of wound healing. Full article
(This article belongs to the Special Issue Novel Antibacterial Materials and Coatings)
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