Anti-Neurodegenerative Agents from Natural Resources
A special issue of Medicines (ISSN 2305-6320).
Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 6479
Special Issue Editor
Interests: application on dopamine biosynthesis and catabolism; signaling pathway of L-DOPA-induced oxidative neurotoxicity; ameliorative agents for neurodegenerative diseases, including Parkinson’s disease
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer’s disease and memory deficits, Parkinson’s disease, affective disorders (anxiety and depression), chronic pain, and sleeping disorders, have been gradually increased by aging, and their symptoms should be relieved for quality of life of the patients. Various pharmacological agents have been developed to manage these diseases, but some of the long-term therapy carry significant adverse effects. Due to the limitations of medication, patients resort to complementary and alternative medicines and one of the medicines used is natural herbal resources/medicines.
Recently, many bioactive components from natural resources have been reported that relive the symptoms of neurodegenerative diseases. However, the clinical applications of these components as mono- and combination-therapies and adjuvant agents still remain undeveloped. These reasons might be raised as the bioactive components are not able to show the desirable efficacy and may also induce the neurotoxicity by their long-term administrations in the animal models and clinical trials. The natural resources for neurodegenerative diseases can be proved the functional efficacy in order to develop as the candidates for herbal medicines, adjuvant agents and adjunctive phytonutrient agents.
The purpose of this Special Issue is to publish original research work related to the “Anti-Neurodegenerative Agents from Natural Resources”, mainly on protective activities of oxidative stress and mitochondrial dysfunction, neuroinflammation, excitoxicity, apoptosis and cell death, and protein aggregation and misfolding. Papers should contribute significantly to furthering scientific knowledge in the above-mentioned scientific fields.
Prof. Dr. Myung Koo Lee
Guest Editor
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Keywords
- neurodegenerative diseases
- evidence-based and adjuvant medicines
- adjunctive phytonutrient agents
- oxidative stress and mitochondrial dysfunction
- neuroinflammation and excitoxicity
- apoptosis and cell death
- clinical application
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