Microfluidic Devices for DNA Applications

Dear Colleagues,

Microfluidic devices have revolutionized DNA manipulations and applications by precisely controlling small volumes of fluids at a microscale. These platforms enable the automatic completion of multiple experimental processes on a single chip, offering advantages such as reduced reagent consumption, high-throughput capabilities, and integration with various analytical tools. The major progress in microfluidics in DNA technology includes the miniaturization of PCR for DNA amplification, high-throughput DNA sequencing, single-cell DNA analysis, the isolation and examination of individual cells, and virus detection. The field is evolving towards integrated systems, point-of-care applications, and increased automation, promising ongoing advancements in genomics, diagnostics, and personalized medicine. Microfluidics stands as a transformative technology, shaping the future of DNA applications and contributing to groundbreaking discoveries in the realm of genetic analysis. This Special Issue aims to cover recent progress and trends in microfluidics for DNA applications. The up-to-date novel approaches and methods in analytical practice for virus detection, nucleic acid analysis, and immunoassays, including electrochemical biosensor, photochemical methods, and surface-enhanced Raman spectroscopy, fit within the focus of this Special Issue. This Special Issue is open to all types of using microfluids for DNA preparation and analytical techniques and their synergistic combinations, particularly (but not limited to) the following areas:

• DNA/RNA sampling and detection;
• digital PCR;
• isothermal amplification;
• CRIPSR;
• lipid mRNA nanoparticles;
• exosomes;
• single-cell-based separation and diagnostics.

Dr. Hongjie An
Guest Editor

Manuscript Submission Information

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• micro/nanofluidics
• DNA/RNA
• PCR
• CRIPSR
• exosomes
• single-cell devices/applications