Micro/Nano Devices for Drug Delivery

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B5: Drug Delivery System".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2860

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854-5104, USA
Interests: hydrogels; contrast agents; micelles; drug delivery; nanomedicine; block co-polymers
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Guest Editor
The Herff College of Engineering Directory, Department of Biomedical Engineering, The University of Memphis, Memphis, TN, USA
Interests: biopolymers; polymeric hydrogels; nanocomposites
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Special Issue Information

Dear Colleagues,

With the understanding of disease pathology, various strategies have been gradually established for guiding the preparation of novel drug formulations. In order to maximize the therapeutic effects of drugs and minimize the side effects, drug delivery vehicles/careers have been developed in past decades. Micro/nano device-based careers are one of the most versatile techniques in recent years because of their ability to solve the challenges associated with delivering poor solubility of therapeutic compounds. The process of encapsulating an active principle in a micro or nanosystem surrounding the action is itself an enormous scientific advancement in pharmaceutical science. Micro and nanoencapsulation of actives require a great effort in establishing the best experimental conditions to preserve the drug from premature degradation, assess the best components of the micro/nanosystem, provide the most suitable processing conditions, and guarantee the desired therapeutic effect.

Considering your prominent contribution in this research area, I would like to invite you to submit a high-quality original communication/full-length research article for this Special Issue that primarily exploits the micro/nano devices for drug delivery towards the enrichment of knowledge pertaining to it. Furthermore, this Special Issue intends to cover review articles that are focused on state- of-the-art for the design and synthesis of nano/micro devices, and strategies to facilitate the drug loading and release followed by assessment of toxicity in a physiological environment.

Dr. Kalyan Ramesh
Dr. Tippabattini Jayaramudu 
Guest Editors

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Keywords

  • polymeric materials
  • inorganic nano particles
  • drug delivery
  • block copolymers
  • metal nano particles
  • biomaterials
  • organic nano particles
  • biocompatible and biodegradable
  • targeted drug delivery
  • nanomedicines

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Published Papers (1 paper)

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Research

11 pages, 2498 KiB  
Article
Magnetically Actuated Microscaffold with Controllable Magnetization and Morphology for Regeneration of Osteochondral Tissue
by Junhyeok Lee, Hyeong-Woo Song, Kim Tien Nguyen, Seokjae Kim, Minghui Nan, Jong-Oh Park, Gwangjun Go and Eunpyo Choi
Micromachines 2023, 14(2), 434; https://doi.org/10.3390/mi14020434 - 11 Feb 2023
Cited by 4 | Viewed by 2181
Abstract
Magnetic microscaffolds capable of targeted cell delivery have been developed for tissue regeneration. However, the microscaffolds developed so far with similar morphologies have limitations for applications to osteochondral disease, which requires simultaneous treatment of the cartilage and subchondral bone. This study proposes magnetically [...] Read more.
Magnetic microscaffolds capable of targeted cell delivery have been developed for tissue regeneration. However, the microscaffolds developed so far with similar morphologies have limitations for applications to osteochondral disease, which requires simultaneous treatment of the cartilage and subchondral bone. This study proposes magnetically actuated microscaffolds tailored to the cartilage and subchondral bone for osteochondral tissue regeneration, named magnetically actuated microscaffolds for cartilage regeneration (MAM-CR) and for subchondral bone regeneration (MAM-SBR). The morphologies of the microscaffolds were controlled using a double emulsion and microfluidic flow. In addition, due to their different sizes, MAM-CR and MAM-SBR have different magnetizations because of the different amounts of magnetic nanoparticles attached to their surfaces. In terms of biocompatibility, both microscaffolds were shown to grow cells without toxicity as potential cell carriers. In magnetic actuation tests of the microscaffolds, the relatively larger MAM-SBR moved faster than the MAM-CR under the same magnetic field strength. In a feasibility test, the magnetic targeting of the microscaffolds in 3D knee cartilage phantoms showed that the MAM-SBR and MAM-CR were sequentially moved to the target sites. Thus, the proposed magnetically actuated microscaffolds provide noninvasive treatment for osteochondral tissue disease. Full article
(This article belongs to the Special Issue Micro/Nano Devices for Drug Delivery)
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