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Micromachines
Special Issues
Research Progress of Microfluidic Bioseparation and Bioassay
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Research Progress of Microfluidic Bioseparation and Bioassay

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 30 January 2025 | Viewed by 4350

Special Issue Editors

Dr. Chi-Ju Kim

E-Mail Website
Guest Editor
Cancer Ecology Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Interests: biomedical engineering; microfluidic devices; cancer; polyaneuploid cancer cells; liquid biopsy; extracellular vesicles
Dr. Junyoung Kim

E-Mail Website
Guest Editor
Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Interests: drug delivery; organ-on-a-chip; cell-to-cell communication; tumor metastasis
Prof. Dr. Sun Min Kim

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Inha University, Incheon 22212, Republic of Korea
Interests: microfluidics; micromixer; lab-on-a-chip; organ-on-a-chip; biosensor; biochip; MicroTAS
Prof. Dr. Franck Chollet

E-Mail Website
Guest Editor
Institute FEMTO-ST, Université Bourgogne-Franche-Comté, 25030 Besançon, France
Interests: microfabrication; microfluidics; lab-on-chip; integrated optics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic bioseparation focuses on the separation and purification of biological target components from a biological sample, and it is usually integrated with a bioassay, which involves the detection and quantification of specific analytes in a sample using miniaturized fluidic devices and techniques. Microfluidic bioseparation techniques have become increasingly vital in the field of bioanalysis and biomedical research due to the several key advantages and applications they offer; they are able to miniaturize and integrate complex bioanalytical workflows into a single device, enhance the sensitivity and throughput, and reduce the analysis time and cost. They therefore enable automation and the performance of high-throughput bioassay with multifunctionality and versatility for point-of-care and field applications relevant to drug discovery, genomics, proteomics, and clinical diagnostics. This Special Issue aims to address the recent progress in microfluidic bioseparation and integrated bioassay, welcoming original research articles, technical notes, and review articles. We hope to provide a collection of high-quality papers and a comprehensive overview of the latest advancements in microfluidic bioseparation and bioassay.

Dr. Chi-Ju Kim
Dr. Junyoung Kim
Prof. Dr. Sun Min Kim
Prof. Dr. Franck Chollet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioseparation
  • bioassay
  • microfluidics
  • lab on a chip
  • bioparticles
  • liquid biopsy
  • point-of-care test

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Published Papers (3 papers)

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Research

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11 pages, 5719 KiB  
Article
An Optofluidic Young Interferometer for Electrokinetic Transport-Coupled Biosensing
by Elisabetta Labella and Ruchi Gupta
Micromachines 2024, 15(7), 861; https://doi.org/10.3390/mi15070861 - 30 Jun 2024
Viewed by 639
Abstract
Label-free optical biosensors, such as interferometers, can provide a comparable limit of detection to widely used enzyme-linked immunosorbent assays while minimizing the number of steps and reducing false positives/negatives. In 2020, the authors reported on a novel optofluidic Young interferometer (YI) that could [...] Read more.
Label-free optical biosensors, such as interferometers, can provide a comparable limit of detection to widely used enzyme-linked immunosorbent assays while minimizing the number of steps and reducing false positives/negatives. In 2020, the authors reported on a novel optofluidic Young interferometer (YI) that could provide real-time spatial information on refractive index changes occurring along the length of the sensor and reference channels. Herein, we exploit these features of the YI to study interactions of biomolecules with recognition elements immobilized in selected regions of agarose gel in the sensor channel. We show that the YI is well suited for the biosensing of an exemplar biomolecule, streptavidin, in the absence and presence of the bovine serum albumin interferent. Equally, we couple the YI with electrokinetic transport to reduce the time needed for biosensing. Full article
(This article belongs to the Special Issue Research Progress of Microfluidic Bioseparation and Bioassay)
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19 pages, 5117 KiB  
Article
The Shape Effect of Acoustic Micropillar Array Chips in Flexible Label-Free Separation of Cancer Cells
by Lin Lin, Rongxing Zhu, Wang Li, Guoqiang Dong and Hui You
Micromachines 2024, 15(4), 421; https://doi.org/10.3390/mi15040421 - 22 Mar 2024
Viewed by 1423
Abstract
The precise isolation of circulating tumor cells (CTCs) from blood samples is a potent tool for cancer diagnosis and clinical prognosis. However, CTCs are present in extremely low quantities in the bloodstream, posing a significant challenge to their isolation. In this study, we [...] Read more.
The precise isolation of circulating tumor cells (CTCs) from blood samples is a potent tool for cancer diagnosis and clinical prognosis. However, CTCs are present in extremely low quantities in the bloodstream, posing a significant challenge to their isolation. In this study, we propose a non-contact acoustic micropillar array (AMPA) chip based on acoustic streaming for the flexible, label-free capture of cancer cells. Three shapes of micropillar array chips (circular, rhombus, and square) were fabricated. The acoustic streaming characteristics generated by the vibration of microstructures of different shapes are studied in depth by combining simulation and experiment. The critical parameters (voltage and flow rate) of the device were systematically investigated using microparticle experiments to optimize capture performance. Subsequently, the capture efficiencies of the three micropillar structures were experimentally evaluated using mouse whole blood samples containing cancer cells. The experimental results revealed that the rhombus microstructure was selected as the optimal shape, demonstrating high capture efficiency (93%) and cell activity (96%). Moreover, the reversibility of the acoustic streaming was harnessed for the flexible release and capture of cancer cells, facilitating optical detection and analysis. This work holds promise for applications in monitoring cancer metastasis, bio-detection, and beyond. Full article
(This article belongs to the Special Issue Research Progress of Microfluidic Bioseparation and Bioassay)
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Review

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20 pages, 2494 KiB  
Review
Cell Migration Assays and Their Application to Wound Healing Assays—A Critical Review
by Chun Yang, Di Yin, Hongbo Zhang, Ildiko Badea, Shih-Mo Yang and Wenjun Zhang
Micromachines 2024, 15(6), 720; https://doi.org/10.3390/mi15060720 - 29 May 2024
Cited by 2 | Viewed by 1767
Abstract
In recent years, cell migration assays (CMAs) have emerged as a tool to study the migration of cells along with their physiological responses under various stimuli, including both mechanical and bio-chemical properties. CMAs are a generic system in that they support various biological [...] Read more.
In recent years, cell migration assays (CMAs) have emerged as a tool to study the migration of cells along with their physiological responses under various stimuli, including both mechanical and bio-chemical properties. CMAs are a generic system in that they support various biological applications, such as wound healing assays. In this paper, we review the development of the CMA in the context of its application to wound healing assays. As such, the wound healing assay will be used to derive the requirements on CMAs. This paper will provide a comprehensive and critical review of the development of CMAs along with their application to wound healing assays. One salient feature of our methodology in this paper is the application of the so-called design thinking; namely we define the requirements of CMAs first and then take them as a benchmark for various developments of CMAs in the literature. The state-of-the-art CMAs are compared with this benchmark to derive the knowledge and technological gap with CMAs in the literature. We will also discuss future research directions for the CMA together with its application to wound healing assays. Full article
(This article belongs to the Special Issue Research Progress of Microfluidic Bioseparation and Bioassay)
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