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Micromachines
Special Issues
Micromanipulation in Microfluidics
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Micromanipulation in Microfluidics

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (10 January 2020) | Viewed by 14476

Special Issue Editors

Dr. Itziar González

E-Mail Website
Guest Editor
Institute of Physics and Information Technologies, Group of Ultrasonic Resonators, CSIC, Serrano 144, 28006 Madrid, Spain
Interests: lab on a chip; microfluidics; ultrasounds; cell sorting/aggregation; microresonators
Special Issues, Collections and Topics in MDPI journals
Dr. Pilar Carreras

E-Mail Website
Guest Editor
Research collaborator at Institute of Physics and Information Technologies, Group of Ultrasonic Resonators, CSIC, Serrano 144, 28006 Madrid, Spain
Interests: microfluidic sorting; microdroplet; microfluidic cell culture, stem cell, biomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Researchers,

We are opening this Special Issue entitled “Micromanipulation in Microfluidics”, which aims to cover recent progress in this field.

Microfluidics is becoming a key technology in an expanding range of fields, including medical sciences, biomanipulation, biosensing, chemical and biological processes, and more. This Special Issue will focus on current emerging methods involving microfluidics for micromanipulation of particles, droplets, cells, and other submicronic elements.

Authors are encouraged to submit novel research papers and reviews, with areas of focus that include but are not limited to the following:

1) Combining microfluidics with external systems for sorting purposes: Magnetophoresis, dielectrophoresis, acoustophoresis, hydrodynamic strategies, optical tweezers;

2) Droplet technologies for biological manipulation;

3) Modeling/simulation issues related to manipulation in microfluidics;

4) Microfluidic devices and methods for tissue engineering;

5) “Smart” fabrication materials and components.

Dr. Itziar González
Dr. Pilar Carreras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical tweezers
  • acoustic tweezers
  • dielectrophoresis
  • microdroplets
  • microfluidic sonochemical and sonoluminiscence mixers
  • pumps
  • cell sorting
  • plasmapheresis
  • new microfluidic strategies in organ-on-chip

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Published Papers (2 papers)

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Research

9 pages, 2843 KiB  
Article
Droplet Microfluidics for the ex Vivo Expansion of Human Primary Multiple Myeloma Cells
by Pilar Carreras, Iciar Gonzalez, Miguel Gallardo, Alejandra Ortiz-Ruiz and Joaquin Martinez-Lopez
Micromachines 2020, 11(3), 261; https://doi.org/10.3390/mi11030261 - 29 Feb 2020
Cited by 6 | Viewed by 3395
Abstract
We previously reported a new approach for micromanipulation and encapsulation of human stem cells using a droplet-based microfluidic device We demonstrated the possibility of encapsulating and culturing difficult-to-preserve primary human hematopoietic stem cells using an engineered double layered bead composed by an inner [...] Read more.
We previously reported a new approach for micromanipulation and encapsulation of human stem cells using a droplet-based microfluidic device We demonstrated the possibility of encapsulating and culturing difficult-to-preserve primary human hematopoietic stem cells using an engineered double layered bead composed by an inner layer of alginate and an outer layer of puramatrix constructed using a soft technology without the use of any external force. In this work, we use this micro manipulation technique to build a 3D scaffold as a biomimetic model to recapitulate the niche of patient-derived multiple myeloma cells (MM cell) using a multilayered 3D tissue scaffold constructed in a microfluidic device and cultured in 10% FBS culture medium. In the current study, we included the use of this biomimetic model comprising supporting human Mesenchymal stem cells to show the mid-term survival of MM cells in the proposed structures. We found that the generated microniches were suitable for the maintenance of MM cells with and without supporting cells. Additionally, cultured MM cells in droplets were exposed to both Bortezomib and Lenalidomide to test their toxicity in the cultured patient derived cells. Results indicate that the maintained MM cells were consistently responding to the applied medication, opening a wide field of possibilities to use the presented micro device as an ex vivo platform for drug screening. Full article
(This article belongs to the Special Issue Micromanipulation in Microfluidics)
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11 pages, 2784 KiB  
Article
Numerical Simulation of Boundary-Driven Acoustic Streaming in Microfluidic Channels with Circular Cross-Sections
by Junjun Lei, Feng Cheng and Kemin Li
Micromachines 2020, 11(3), 240; https://doi.org/10.3390/mi11030240 - 26 Feb 2020
Cited by 29 | Viewed by 10725
Abstract
While acoustic streaming patterns in microfluidic channels with rectangular cross-sections have been widely shown in the literature, boundary-driven streaming fields in non-rectangular channels have not been well studied. In this paper, a two-dimensional numerical model was developed to simulate the boundary-driven streaming fields [...] Read more.
While acoustic streaming patterns in microfluidic channels with rectangular cross-sections have been widely shown in the literature, boundary-driven streaming fields in non-rectangular channels have not been well studied. In this paper, a two-dimensional numerical model was developed to simulate the boundary-driven streaming fields on cross-sections of cylindrical fluid channels. Firstly, the linear acoustic pressure fields at the resonant frequencies were solved from the Helmholtz equation. Subsequently, the outer boundary-driven streaming fields in the bulk of fluid were modelled while using Nyborg’s limiting velocity method, of which the limiting velocity equations were extended to be applicable for cylindrical surfaces in this work. In particular, acoustic streaming fields in the primary (1, 0) mode were presented. The results are expected to be valuable to the study of basic physical aspects of microparticle acoustophoresis in microfluidic channels with circular cross-sections and the design of acoustofluidic devices for micromanipulation. Full article
(This article belongs to the Special Issue Micromanipulation in Microfluidics)
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