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Micromachines
Special Issues
Immunoassay Platforms for Biomedical Detection
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Immunoassay Platforms for Biomedical Detection

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 1264

Special Issue Editors

Dr. Jian Gu

E-Mail Website
Guest Editor
Center for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA
Interests: immunoassay; lateral/vertical flow assays; nano/microfluidics; nano/microscale biosensors; biosensor system integration
Dr. Chao Wang

E-Mail Website
Guest Editor
School of Electrical, Computer and Energy Engineering, Biodesign Center for Molecular Design and Biomimetics, Arizona State University, Tempe, AZ 85281, USA
Interests: nanofabrication; nanophotonics; portable electronic detectors; nanopore sensors; infectious diseases

Special Issue Information

Dear Colleagues,

This special issue of Micromachines, titled “Immunoassay Platforms for Biomedical Detection”, hopes to cover all aspects of the immunoassay for biomedical applications. Immunoassays have been explored and implemented for the detection of specific biological agents and markers for a wide ranges of biomedical applications, including point-of-care testings for emerging infectious diseases, health monitoring both on earth and in space, disease management and personalized medicine, screening and monitoring of allergies and drug abuse, food and water safety control, etc. Development of immunoassays has moved towards the rapid, sensitivive and multiplexed detection of biomarkers at higher throughput levels and at a lower cost or using low-resource settings. In this Special Issue, we invite full research papers, review articles and communications to showcase the recent innovations in immunoassay novel materials/structures for signal transduction, assay designs, device fabrication, sensing theories and simulation, reader technologies and system integration, as well as their applications in biomedical fields.

Dr. Jian Gu
Dr. Chao Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunoassay
  • lateral/vertical flow assays
  • nano/microfluidics
  • nano/microscale biosensors
  • biosensor system integration
  • lab-on-a-chip
  • point-of-care testing
  • healthcare and environmental monitoring

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Published Papers (1 paper)

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Research

13 pages, 10049 KiB  
Article
Rapid and Sensitive Detection of Thrombospondin-2 Using Nanoparticle Sensors for Cancer Screening and Prognosis
by Maziyar Kalateh Mohammadi, Seyedsina Mirjalili, Md Ashif Ikbal, Hao Xie and Chao Wang
Micromachines 2025, 16(3), 354; https://doi.org/10.3390/mi16030354 - 20 Mar 2025
Viewed by 409
Abstract
Thrombospondin-2 (THBS2) is a prevailing prognostic biomarker implicated in different cancer types, such as deadly colorectal, pancreas, and triple-negative breast cancers. While the current methods for cancer-relevant protein detection, such as enzyme-linked immunosorbent assay (ELISA), mass spectrometry, and immunohistochemistry, are feasible at advanced [...] Read more.
Thrombospondin-2 (THBS2) is a prevailing prognostic biomarker implicated in different cancer types, such as deadly colorectal, pancreas, and triple-negative breast cancers. While the current methods for cancer-relevant protein detection, such as enzyme-linked immunosorbent assay (ELISA), mass spectrometry, and immunohistochemistry, are feasible at advanced stages, they have shortcomings in sensitivity, specificity, and accessibility, particularly at low concentrations in complex biological fluids for early detection. Here, we propose and demonstrate a modular, in-solution assay design concept, Nanoparticle-Supported Rapid Electronic Detection (NasRED), as a versatile cancer screening and diagnostic platform. NasRED utilizes antibody-functionalized gold nanoparticles (AuNPs) to capture target proteins from a minute amount of sample (<10 µL) and achieve optimal performance with a short assay time by introducing active fluidic forces that act to promote biochemical reaction and accelerate signal transduction. This rapid (15 min) process serves to form AuNP clusters upon THBS2 binding and subsequently precipitate such clusters, resulting in color modulation of the test tubes that is dependent on the THBS2 concentration. Finally, a semiconductor-based, portable electronic device is used to digitize the optical signals for the sensitive detection of THBS2. High sensitivity (femtomolar level) and a large dynamic range (five orders of magnitude) are obtained to analyze THBS2 spiked in PBS, serum, whole blood, saliva, cerebrospinal fluids, and synovial fluids. High specificity is also preserved in differentiating THBS2 from other markers such as cancer antigen (CA) 19-9 and bovine serum albumin (BSA). This study highlights NasRED’s potential to enhance cancer prognosis and screening by offering a cost-effective, accessible, and minimally invasive solution. Full article
(This article belongs to the Special Issue Immunoassay Platforms for Biomedical Detection)
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