Microbiomes and Cancer: A New Era in Diagnosis and Therapy
A topical collection in Microorganisms (ISSN 2076-2607). This collection belongs to the section "Microbiomes".
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Interests: probiotics; microbiota; microbiome; beneficial microbes; multi-omics; lactic acid bacteria
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
The host microbiota is a complex, dynamic community of bacteria, archaea, fungi and protozoa that plays an integral role in gastrointestinal and extraintestinal homeostasis. The contribution of the microbiota to oncogenesis and response to anticancer therapies is a topic of intense research. Indeed, a dysbiotic gut may promote tumorigenesis by sustaining low-grade inflammation and inducing aberrant cell proliferation. Moreover, the involvement of specific pathobionts (i.e., Helicobacter pylori and Fusobacterium nucleatum) in the development of gastrointestinal cancer has been highlighted in recent studies. In this vein, mechanistic insight into the contribution of specific microbes to carcinogenesis may support the design of minimally invasive prognostic and diagnostic tools.
At the same time, breakthrough studies have linked the composition and function of the microbiome to the response to anticancer therapy. Specifically, animal and clinical studies show that commensal as well as probiotic bacteria may modulate the response to chemotherapy, actinotherapy, and immunotherapy. Immune checkpoint inhibitors (ICIs) and CAR-T cell therapies have, recently, gained traction due to the lasting effects and better tolerance in patients with solid tumours compared to conventional treatment. However, some individuals show limited response or even resistance to these modalities. To this end, elucidating the contribution of microbiomes to treatment response may support the design of patient-specific strategies, including fecal microbiota transplantation, with increased efficacy and safety.
As the Collection Editor of this Collection, Ι would like to invite you to submit original research articles, reviews, and short communications on the role of microbiomes in cancer prognosis, diagnosis, and therapy.
Dr. Alex Galanis
Collection Editor
Manuscript Submission Information
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Keywords
- microbiome
- animal models
- clinical studies
- CAR-T cell therapy
- anticancer therapy
- cancer immunotherapy
- cancer prognosis
- cancer diagnosis
- pathobionts
- probiotics
- fecal microbiota transplantation
