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Design, Characterization and Application of Surfactants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 991

Special Issue Editor


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Guest Editor
The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, 1800 Lihu Road, Wuxi, China
Interests: surfactant; emulsions; micelles; foams; stimulus-responsive; colloids

Special Issue Information

Dear Colleagues,

Surfactants usually consist of hydrophilic and hydrophobic molecular sections. They are commonly used in industry, pharmacology, agriculture, detergents, cosmetics, paintings, textiles, dyeing, polymers, foodstuffs, medicine, oil recovery, and petroleum production. In addition, surfactants have also found applications in microbiology, nanotechnology, micellar catalysts, wet chemicals, and wastewater treatment. The global production of surfactants is more than 10 million tonnes per year. Recently, various surfactants with novel structures and efficient performances have been designed and synthesized, providing more solutions and opportunities for consumer and industrial applications.

The main aim of this Special Issue, entitled “Design, Characterization and Application of Surfactants,” is to provide an open forum where researchers can share their methods for designing and synthesizing novel surfactants, as well as their findings in their unique properties and applications in promising fields. Contributions to this Special Issue, both in the form of original research or review articles, may cover all aspects of the synthesis, characteristics and applications of different types of surfactants. I hope that this issue will increase the understanding of the structures and properties of surfactants and encourage more scholars to share their achievements, and I would like to thank the authors for their valuable contributions.

Prof. Dr. Jianzhong Jiang
Guest Editor

Manuscript Submission Information

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Keywords

  • surfactants
  • synthesis
  • application
  • properties
  • wettability
  • interfacial tension
  • micelles
  • emulsions
  • vesicle
  • foams

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Published Papers (1 paper)

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Research

23 pages, 5334 KiB  
Article
Antimicrobial and Anesthetic Niosomal Formulations Based on Amino Acid-Derived Surfactants
by Martina Romeo, Zakaria Hafidi, Rita Muzzalupo, Ramon Pons, María Teresa García, Elisabetta Mazzotta and Lourdes Pérez
Molecules 2024, 29(12), 2843; https://doi.org/10.3390/molecules29122843 - 14 Jun 2024
Cited by 1 | Viewed by 800
Abstract
Background: This work proposes the development of new vesicular systems based on anesthetic compounds (lidocaine (LID) and capsaicin (CA)) and antimicrobial agents (amino acid-based surfactants from phenylalanine), with a focus on physicochemical characterization and the evaluation of antimicrobial and cytotoxic properties. Method: Phenylalanine [...] Read more.
Background: This work proposes the development of new vesicular systems based on anesthetic compounds (lidocaine (LID) and capsaicin (CA)) and antimicrobial agents (amino acid-based surfactants from phenylalanine), with a focus on physicochemical characterization and the evaluation of antimicrobial and cytotoxic properties. Method: Phenylalanine surfactants were characterized via high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR). Different niosomal systems based on capsaicin, lidocaine, cationic phenylalanine surfactants, and dipalmitoyl phosphatidylcholine (DPPC) were characterized in terms of size, polydispersion index (PI), zeta potential, and encapsulation efficiency using dynamic light scattering (DLS), transmitted light microscopy (TEM), and small-angle X-ray scattering (SAXS). Furthermore, the interaction of the pure compounds used to prepare the niosomal formulations with DPPC monolayers was determined using a Langmuir balance. The antibacterial activity of the vesicular systems and their biocompatibility were evaluated, and molecular docking studies were carried out to obtain information about the mechanism by which these compounds interact with bacteria. Results: The stability and reduced size of the analyzed niosomal formulations demonstrate their potential in pharmaceutical applications. The nanosystems exhibit promising antimicrobial activity, marking a significant advancement in pharmaceutical delivery systems with dual therapeutic properties. The biocompatibility of some formulations underscores their viability. Conclusions: The proposed niosomal formulations could constitute an important advance in the pharmaceutical field, offering delivery systems for combined therapies thanks to the pharmacological properties of the individual components. Full article
(This article belongs to the Special Issue Design, Characterization and Application of Surfactants)
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