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Green Catalysis in Organic Synthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1472

Special Issue Editor

School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China
Interests: green solvent; valorization of bio-derived molecules; tandem catalysis

Special Issue Information

Dear Colleagues,

Today, given the plethora of synthetic methods at our disposal, the challenges for organic synthesis go beyond that of increasing molecular complexity and toward encompassing more convergent, atom/step efficient, and sustainable processes. In recognition of the inevitable transition that must take place, great efforts are being devoted to developing processes that are sustainable. This Special Issue welcomes original research on the development of ecofriendly processes not only for organic chemistry but also for materials chemistry. Topics of interest include but are not limited to the following: (1) biomass and valorization of its downstream platform molecules, (2) catalysis in green solvents, (3) atom- or step-economic reactions, and (4) waste-minimized processes.

Dr. Minghao Li
Guest Editor

Manuscript Submission Information

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Keywords

  • green solvent
  • biomass valorization
  • tandem catalysis
  • photocatalysis
  • electrocatalysis
  • heterogeneous catalysis
  • homogeneous catalysis
  • acid catalysis
  • transition metal catalysis
  • functional materials

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Published Papers (1 paper)

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Research

19 pages, 1615 KiB  
Article
Visible Light-Mediated Monofluoromethylation/Acylation of Olefins by Dual Organo-Catalysis
by Jiuli Xia, Yunliang Guo, Zhiguang Lv, Jiaqiong Sun, Guangfan Zheng and Qian Zhang
Molecules 2024, 29(4), 790; https://doi.org/10.3390/molecules29040790 - 8 Feb 2024
Cited by 2 | Viewed by 1109
Abstract
Monofluoromethyl (CH2F) motifs exhibit unique bioactivities and are considered privileged units in drug discovery. The radical monofluoromethylative difunctionalization of alkenes stands out as an appealing approach to access CH2F-containing compounds. However, this strategy remains largely underdeveloped, particularly under metal-free [...] Read more.
Monofluoromethyl (CH2F) motifs exhibit unique bioactivities and are considered privileged units in drug discovery. The radical monofluoromethylative difunctionalization of alkenes stands out as an appealing approach to access CH2F-containing compounds. However, this strategy remains largely underdeveloped, particularly under metal-free conditions. In this study, we report on visible light-mediated three-component monofluoromethylation/acylation of styrene derivatives employing NHC and organic photocatalyst dual catalysis. A diverse array of α-aryl-β-monofluoromethyl ketones was successfully synthesized with excellent functional group tolerance and selectivity. The mild and metal-free CH2F radical generation strategy from NaSO2CFH2 holds potential for further applications in fluoroalkyl radical chemistry. Full article
(This article belongs to the Special Issue Green Catalysis in Organic Synthesis)
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