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Fluorescent Probe: Design, Synthesis and Application

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1325

Special Issue Editors

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Interests: fluorescent sensors; bioimaging; disease diagnosis; disease markers; biomolecular research
Special Issues, Collections and Topics in MDPI journals
School of Pharmaceutical Science, Hebei Medical University, Shijiazhuang 050017, China
Interests: theranostics; PDT; biosensor; fluorescent; anticancer

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Guest Editor
College of Science, Huazhong Agricultural University, Wuhan 430070, China
Interests: electrochemical; ECL; DNA nanotechnology; food safety analysis; bioimaging

Special Issue Information

Dear Colleagues,

This Special Issue will provide up-to-date information on the design, synthesis and applications of fluorescent probes. The development of fluorescent probes for various analytes has been actively pursued by chemists, and many new probes have found wide applications in the fields of chemistry, biology, environmental science and physiology. The targets for probes vary from metal ions to anions, reactive oxygen/nitrogen species, biothiols and toxic gases. New advances in this field will stimulate further activity aimed at devising approaches to new target analytes or for disease diagnosis, environmental problems‘ solutions and so on.

Contributions to this Special Issue may cover all advances related to fluorescent probe development, including chemosensor development, biosensor development, new target analyte recognition, biological applications in the food industry and environmental applications.

Dr. Ying Hu
Dr. Yifan Liu
Dr. Wenjing Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent probe
  • chemical probes
  • biosensors
  • design of molecular probe
  • synthesis of molecular probe
  • biological applications

Published Papers (1 paper)

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Research

13 pages, 3119 KiB  
Article
A Ratiometric Fluorescent Probe for N2H4 Having a Large Detection Range Based upon Coumarin with Multiple Applications
by Xiao Sheng, Xinfeng Sun, Yiwen Zhang, Chen Zhang, Shuling Liu and Shouxin Wang
Molecules 2023, 28(22), 7629; https://doi.org/10.3390/molecules28227629 - 16 Nov 2023
Cited by 2 | Viewed by 964
Abstract
Although hydrazine (N2H4) is a versatile chemical used in many applications, it is toxic, and its leakage may pose a threat to both human health and environments. Consequently, the monitoring of N2H4 is significant. This study [...] Read more.
Although hydrazine (N2H4) is a versatile chemical used in many applications, it is toxic, and its leakage may pose a threat to both human health and environments. Consequently, the monitoring of N2H4 is significant. This study reports a one-step synthesis for coumarin-based ratiometric fluorescent probe (FP) CHAC, with acetyl as the recognition group. Selected deprotection of the acetyl group via N2H4 released the coumarin fluorophore, which recovered the intramolecular charge transfer process, which caused a prominent fluorescent, ratiometric response. CHAC demonstrated the advantages of high selectivity, a strong capacity for anti-interference, a low limit of detection (LOD) (0.16 μM), a large linear detection range (0–500 μM), and a wide effective pH interval (6–12) in N2H4 detection. Furthermore, the probe enabled quantitative N2H4 verifications in environmental water specimens in addition to qualitative detection of N2H4 in various soils and of gaseous N2H4. Finally, the probe ratiometrically monitored N2H4 in living cells having low cytotoxicity. Full article
(This article belongs to the Special Issue Fluorescent Probe: Design, Synthesis and Application)
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