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Development of Advanced Analytical Methods for Drugs and Biologically Active...
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Development of Advanced Analytical Methods for Drugs and Biologically Active Substances

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5567

Special Issue Editors

Dr. Mario-Livio Jeličić

E-Mail Website
Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: sample preparation; pharmaceutical analysis; drug compatibility; quality control; chromatography; method development; method validation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ana Mornar

E-Mail Website
Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: drug development; sample preparation; pharmaceutical analysis; biopharmaceutical analysis; food analysis; chromatography; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Daniela Amidžić Klarić

E-Mail Website
Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: pharmaceutical analysis; supplement analysis; sample preparation; atomic spectroscopy; chromatography; food analytical chemistry; food control; bioactive compounds; metals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Analytical method development is crucial to the complex and long-lasting drug development process. The importance of this aspect is unquestionable since behind every pharmaceutical product placed on market there is a set of carefully developed and validated analytical methods. These methods serve the purpose of assuring the unambiguous determination of the drug’s quality, securing the safety and efficacy of the product. On the other side, once a drug product is taken by a patient, analytical methods serve as a tool for monitoring the pharmacokinetics of the drug, which is a challenge considering the composition of biological samples.

In this Special Issue of Molecules titled “Development of Advanced Analytical Methods for Drugs and Biologically Active Substances”, we encourage researchers to publish original and novel methods developed for the analysis of drugs in various matrices. Methods where analytes are biologically active substances are especially welcome, as are methods including the pre-treatment of biological samples. Research focused on the application of innovative lab-on-chip technology in pharmaceutical and biopharmaceutical analysis are also welcomed.

Submitted papers should clearly state the novelty of the work. There is no limitation of instrumentation; we encourage scientists to use ‘’in-house’’ concepts as well as ‘’out-of-the-box’’ approaches using conventional equipment.

Thank you for considering publishing your work in our Special Issue.

Dr. Mario-Livio Jeličić
Prof. Dr. Ana Mornar
Dr. Daniela Amidžić Klarić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug analysis
  • bioanalysis
  • method development
  • method validation
  • drug development
  • pharmaceutical technology
  • quality control
  • sample preparation
  • assay determination
  • impurity determination

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

11 pages, 2075 KiB  
Article
Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method
by Oxana Ye. Rodionova, Alexey L. Pomerantsev and Douglas N. Rutledge
Molecules 2022, 27(22), 7904; https://doi.org/10.3390/molecules27227904 - 15 Nov 2022
Viewed by 1213
Abstract
This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the [...] Read more.
This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic blisters and the spectra of the pure substance. Fresh samples and samples at different stages of degradation are analyzed. No methods of accelerated aging were applied. Multi-step application of MCR-ALS in its soft version followed by the kinetic modeling of the results helps to propose a generic degradation mechanism; which includes: a global kinetic model; approximations of the NIR spectra of the intermediate and product; rough estimates of rate constants. We study tablets in blister packs; exactly as they are presented in pharmacies; and this is important from a practical point of view. Full article
(This article belongs to the Special Issue Development of Advanced Analytical Methods for Drugs and Biologically Active Substances)
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14 pages, 1380 KiB  
Article
Development and Validation of a Reversed-Phase HPLC Method with UV Detection for the Determination of L-Dopa in Vicia faba L. Broad Beans
by Carmen Tesoro, Rosanna Ciriello, Filomena Lelario, Angela Di Capua, Raffaella Pascale, Giuliana Bianco, Mario Dell’Agli, Stefano Piazza, Antonio Guerrieri, Laura Scrano, Sabino A. Bufo and Maria Assunta Acquavia
Molecules 2022, 27(21), 7468; https://doi.org/10.3390/molecules27217468 - 2 Nov 2022
Cited by 5 | Viewed by 2074
Abstract
L-Dopa (LD), a substance used medically in the treatment of Parkinson’s disease, is found in several natural products, such as Vicia faba L., also known as broad beans. Due to its low chemical stability, LD analysis in plant matrices requires an appropriate optimization [...] Read more.
L-Dopa (LD), a substance used medically in the treatment of Parkinson’s disease, is found in several natural products, such as Vicia faba L., also known as broad beans. Due to its low chemical stability, LD analysis in plant matrices requires an appropriate optimization of the chosen analytical method to obtain reliable results. This work proposes an HPLC-UV method, validated according to EURACHEM guidelines as regards linearity, limits of detection and quantification, precision, accuracy, and matrix effect. The LD extraction was studied by evaluating its aqueous stability over 3 months. The best chromatographic conditions were found by systematically testing several C18 stationary phases and acidic mobile phases. In addition, the assessment of the best storage treatment of Vicia faba L. broad beans able to preserve a high LD content was performed. The best LD determination conditions include sun-drying storage, extraction in HCl 0.1 M, chromatographic separation with a Discovery C18 column, 250 × 4.6 mm, 5 µm particle size, and 99% formic acid 0.2% v/v and 1% methanol as the mobile phase. The optimized method proposed here overcomes the problems linked to LD stability and separation, thus contributing to the improvement of its analytical determination. Full article
(This article belongs to the Special Issue Development of Advanced Analytical Methods for Drugs and Biologically Active Substances)
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15 pages, 1776 KiB  
Article
Screening of Codonopsis radix Polysaccharides with Different Molecular Weights and Evaluation of Their Immunomodulatory Activity In Vitro and In Vivo
by Guangxin Li, Yanhong Ju, Yuwei Wen, Min Zuo, Chao Wang, Xiaomei Zhang, Xiaoxiang Hou, Guiqing Yang and Jianping Gao
Molecules 2022, 27(17), 5454; https://doi.org/10.3390/molecules27175454 - 25 Aug 2022
Cited by 9 | Viewed by 1758
Abstract
Polysaccharide is one of the main components of Codonopsis radix (CR) and has good immune activity. However, the immune activity of CR polysaccharides with different molecular weights has not been systematically screened. In this study, the polysaccharides of CR from Pingshun [...] Read more.
Polysaccharide is one of the main components of Codonopsis radix (CR) and has good immune activity. However, the immune activity of CR polysaccharides with different molecular weights has not been systematically screened. In this study, the polysaccharides of CR from Pingshun of Shanxi Province (PSDSs) were first divided into two groups using ultrafiltration: 3.3 kDa (PSDSs-1) and more than 2000 kDa (PSDSs-2). The immunomodulatory effects of PSDSs with different molecular weights were evaluated in vitro and in vivo. In vitro experimental results showed that compared with Lipopolysaccharide-induced macrophages, PSDSs-1 increased TNF-α and IL-6 levels and decreased IL-10. Meanwhile, PSDSs-2 showed the opposite effect, indicating the difference in pro- and anti-inflammatory activities of PSDSs with different molecular weights. The immunosuppressive model of cyclophosphamide proved that PSDSs have immune-promoting function, with PSDSs-1 exhibiting a better effect than PSDSs-2. In vitro and in vivo experiments illustrated the complexity of PSDS immunomodulation. Further research on the functions of PSDs with different molecular weights is needed to lay a foundation for their classification and application. Full article
(This article belongs to the Special Issue Development of Advanced Analytical Methods for Drugs and Biologically Active Substances)
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