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Natural Bioactive Compounds: Chemistry, Extraction, Characterization and Health Benefits

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3460

Special Issue Editors


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Guest Editor
Office of Research, Innovation & Commercialization, Lahore College for Women University, Lahore 54000, Pakistan
Interests: natural products; medicinal foods; translational research; complementary and alternative medicine; herbal medicine

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Guest Editor
Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal 18050, Pakistan
Interests: anti-cancer drugs; promising anti-cancer targets; conservative therapy; quality of life; natural products

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Guest Editor
Institute of Industrial Biotechnology, Government College University, Lahore 54590, Pakistan
Interests: microbial drug production; medical microbiology; natural compounds; natural extracts; antibiotic resistance

Special Issue Information

Dear Colleagues,

Natural bioactive compounds and plant extracts comprised small quantities of extranutritional constituents providing both health benefits and enhanced nutritional value, based on their ability to modulate one or more metabolic processes. Plant-based diets are being thoroughly researched for their cardiovascular properties and effectiveness against cancer. Flavonoids, phytoestrogens, phenolic compounds, and carotenoids are some of the bioactive compounds that aim to work in preventing and treating diseases in a systemic manner, including hypertension, atherosclerosis, and heart failure. Since they are obtained from renewable sources, they are not hazardous to health, and can sometimes even have a curative effect. Furthermore, the use of natural dyes does not pose any problems with regard to the disposal of the product. Their antioxidant and anti-inflammatory properties are the most important characteristics and make them favorable candidates for the treatment of various diseases. However, their low water solubility and stability result in low bioavailability, limited accessibility, and poor absorption. The oral delivery of bioactive compounds is constrained due to physiological barriers such as pH, mucus layer, gastrointestinal enzymes, epithelium, etc.

This Special Issue will explore various aspects of natural bioactive compounds, including their sources, phytochemistry, and associated biological activities explored under in vitro and in vivo animal and human studies. A particular focus is placed on innovative technological approaches for the effective extraction of bioactive compounds for nutraceutical and pharmaceutical applications. We welcome original research, review, mini review and perspective articles on themes including, but not limited to: extraction of plant compounds; purification of plant compounds; characterization of plant extracts; identification of bioactive compounds; biological properties of plant compounds/extracts; applications of plant bioactive compounds; bioactive components in fruits and vegetables; extraction of bioactive compounds: conventional and green extraction techniques; phytochemicals from fruit wastes for sustainable and socially acceptable poultry production; pharmacological activities of bioactive compounds; bioactive compounds and health claims; bioactive compounds as natural antioxidants; chemical characterization of bioactive compounds; quality and stability measurements of bioactive compounds; bioactive compounds as functional foods.

Dr. Muhammad Zia-Ul-Haq
Dr. Muhammad Riaz
Dr. Umar Farooq Gohar
Guest Editors

Manuscript Submission Information

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Keywords

  • phytochemicals
  • functional food
  • food composition
  • food and health
  • bioactive compounds
  • fruits
  • vegetables
  • culinary herbs

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Published Papers (1 paper)

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Research

22 pages, 5123 KiB  
Article
Phytochemical Analysis and Profiling of Antitumor Compounds of Leaves and Stems of Calystegia silvatica (Kit.) Griseb.
by Ahmed M. M. Youssef, Doaa A. M. Maaty and Yousef M. Al-Saraireh
Molecules 2023, 28(2), 630; https://doi.org/10.3390/molecules28020630 - 7 Jan 2023
Cited by 9 | Viewed by 2866 | Correction
Abstract
Anti-tumor compounds from natural products are being investigated as possible alternatives for cancer chemotherapeutics that have serious adverse effects and tumor resistance. Calystegia silvatica was collected from the north coast of Egypt and extracted via methanol and n-hexane sub-fraction. The biologically active [...] Read more.
Anti-tumor compounds from natural products are being investigated as possible alternatives for cancer chemotherapeutics that have serious adverse effects and tumor resistance. Calystegia silvatica was collected from the north coast of Egypt and extracted via methanol and n-hexane sub-fraction. The biologically active compounds of Calystegia silvatica were identified from the methanol and n-hexane extracts from the leaves and stems of the plant using GC-MS and HPLC. The antitumor properties of both parts of the plant were investigated against cancer and non-cancer cell lines using the MTT assay, and the IC50 in comparison to doxorubicin was calculated. The main compounds identified in the methanol extract were cis-vaccenic acid and trans-13-octadecenoic acid in the leaves and stems, respectively, and phenyl undecane and 3,7,11,15 tetramethyl-2-hexadeca-1-ol in the n-hexane extracts of the leaves and stems, respectively. Both parts of the plant contained fatty acids that have potential antitumor properties. The methanol extract from the stems of C. silvatica showed antitumor properties against HeLa, with an IC50 of 114 ± 5 μg/mL, PC3 with an IC50 of 137 ± 18 μg/mL and MCF7 with an IC50 of 172 ± 15 μg/mL, which were greater than Caco2, which had an IC50 of 353 ± 19 μg/mL, and HepG2, which had an IC50 of 236 ± 17 μg/mL. However, the leaf extract showed weak antitumor properties against all of the studied cancer cell lines (HeLa with an IC50 of 208 ± 13 μg/mL, PC3 with an IC50 of 336 ± 57 μg/mL, MCF7 with an IC50 of 324 ± 17 μg/mL, Caco2 with an IC50 of 682 ± 55 μg/mL and HepG2 with an IC50 of 593 ± 22 μg/mL). Neither part of the plant extract showed any cytotoxicity to the normal cells (WI38). Therefore, C. silvatica stems may potentially be used for the treatment of cervical, prostate and breast cancer. Full article
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