Heterocyclic Compound: Multicomponent Synthesis and Bioactivity Properties

Dear Colleagues,

Heterocycles are present in human and animal organisms, as well as in plants as components of nucleic acids, sugars, enzymes, hormones, vitamins, pigments, and hemoglobin. In addition, their importance is further enhanced by many synthetic members, such as drugs, pesticides, fine chemicals, and cosmetics. Heterocycles play an important role in various biological investigations such as anticancer, anti-inflammatory, antibacterial, antiviral, anti-tumor, or anti-diabetic studies.

In modern synthetic chemistry, the application of efficient and simple reaction routes for the synthesis of heterocyclic compounds has become more and more important. Therefore, multicomponent reactions (MCRs) attract growing interest. In MCRs, the components react with each other in a “one-pot” manner without the isolation of any intermediates, which may save time and energy. They can be considered as ideal synthetic methods due to their quick and simple procedure, as well as energy-saving and high-atomic-efficiency nature. In general, complex structures can be easily formed from inexpensive and simple starting materials by these transformations. In addition, these properties make them suitable to create large molecular libraries of structurally related compounds.

This Special Issue of Molecules welcomes the submission of research papers and reviews concerning heterocyclic compounds, and mainly focuses on (but is not limited to) multicomponent synthesis, microwave-assisted reactions, continuous flow synthesis, and the biological properties of heterocyclic compounds.

Dr. Erika Bálint
Guest Editor

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• heterocycles
• multicomponent reaction
• one-pot synthesis
• domino reaction
• microwave chemistry
• continuous flow chemistry
• biological activity