Drug Research in Metabolic Bone Diseases and Osteoporosis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3438
Special Issue Editors
2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201009, India
Interests: bone remodeling; osteoanabolics; growth factors; hormones; drug discovery
Special Issue Information
Dear Colleagues,
Metabolic bone disease (MBD) is the third most prevalent endocrine ailment after diseases of the thyroid and diabetes. MBDs cover a wide range of clinically distinct disorders that have a defective skeleton and bone abnormalities caused by the changes in the chemical composition of bone originating from both genetic and non-genetic factors. A variety of hormones and growth factors are responsible for the onset and progression of MBDs, which are generally marked by dramatic clinical presentations that are reversible upon the correction of the underlying causes.
Osteoporosis is the most common form of MBD disease, which is marked by a loss of bone mineral density (BMD) and causes bones to be more prone to fragility fractures. The etiology of osteoporosis is complex and has multiple causes, including hormonal alterations, nutrient deficiency, senility, certain classes of drugs, cancer, and environmental toxicants.
We welcome original research, review articles, meta-analyses, and comments on various aspects of drug discovery as well as development in the context of MBD. Particular attention will be placed on, but not limited to, the following topics:
- Design, synthesis, and optimization of small molecules for MBD.
- Target identification and validation for therapeutic intervention.
- Structure–activity relationship studies and structure-based drug design.
- Computational modeling and virtual screening in drug discovery.
- Innovative drug delivery systems for improved treatment outcomes.
- Pharmacokinetic and pharmacodynamic studies on drug candidates.
- Mechanisms of action and molecular pathways of clinically used drugs in MBD.
- Natural products as potential sources for drug development.*
- New treatments for MBDs and osteoporosis through drug repurposing.
- Drug repurposing and repositioning strategies in metabolic bone disorders.
- Preclinical studies evaluating the efficacy and safety of drug candidates.
* Only studies using well-characterized compounds will be considered, excluding broad plant/animal extracts or fractions.
Prof. Dr. Naibedya Chattopadhyay
Dr. Deepti Sharma
Guest Editors
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Keywords
- osteoporosis
- parathyroid gland
- chronic kidney disease
- bone metastasis
- mineral homeostasis
- hormones
- pharmacotherapy
- drug discovery
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