Small Molecule Inhibitors of Protein Kinases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 9882
Special Issue Editors
Interests: academic drug discovery; anti-inflammatories; anti-cancer; autoimmune; protein kinases; protein-protein interaction
Special Issues, Collections and Topics in MDPI journals
Interests: protein kinase inhibitors; CNS diseases; synthetic organic chemistry; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein kinases represent a large and diverse multi-gene family of enzymes that are involved in numerous cell signaling pathways. They catalyze the transfer of the γ-phosphate group from its natural co-substrate adenosine triphosphate to the free hydroxyl group of a serine, threonine, or tyrosine side chain. Diseases might arise when deregulation or mutation of a kinase takes place.
Kinases are promising drug targets for the treatment of several diseases, such as cancer, inflammation, autoimmune pathologies, or neurodegenerative diseases. Since the approval of imatinib in 2001, 59 kinase inhibitors have been introduced to the market, and numerous kinase inhibitors are currently in different stages of clinical trials.
Both structural data as well as the high-quality kinase probe programs have kept pushing forward the identification of new kinase targets as well as the design of novel kinase inhibitors in recent years. The numbers of reported reversible, covalent, and allosteric small molecule kinase inhibitors has been continuously increasing in the last few years.
This Special Issue aims to attract all researchers working in this research field and will collect new findings and recent advances on the development, synthesis, and structure–activity relationships of novel small molecule kinase inhibitors as well as on novel approaches in protein kinase drug discovery. Research manuscripts as well as a limited number of review manuscripts are welcome.
Prof. Dr. Stefan Laufer
Prof. Dr. Pierre Koch
Guest Editors
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