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Molecules
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NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine
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NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 8971

Special Issue Editors

Dr. Grzegorz Nowaczyk

E-Mail Website
Guest Editor
NanoBioMedical Centere, Adam Mickiewicz University, 61-614 Poznań, Poland
Interests: inorganic and organic nanomaterials; hybrid nanopartciles; high resolution transmission electron microscopy; nanomaterials for catalysis; nanomaterials for biomedical applications; molecular dynamics
Dr. Dorota Katarzyna Flak

E-Mail Website
Guest Editor
NanoBioMedical Centre, Adam Mickiewicz University, 61-614 Poznań, Poland
Interests: synthesis; biofunctionalization and physico-chemical properties of nanomaterials and their application in biomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is related to the NanoTech Poland 2022, the 12th international conference (http://nanotechpoland.amu.edu.pl/) organized by the NanoBioMedical Centre, Adam Mickiewicz University Poznan, which will be held on 1-3 June 2022 in Poznań.

The scope of the conference, and hence the scope of this Special Issue, will cover all aspects of novel nanoparticles, nanocomposites, and hybrid nanostructures and their application in energy, electronics, photonics, biomedicine, and the environment. These aspects will include novel approaches in the design and synthesis of nanomaterials and their functionalization, development of techniques and tools to characterize nanomaterials, current and future challenges and benefits (but also risks) of nanotechnology applications, and implementation of nanomaterials in systems and devices. Participants of the conference, as well as all researchers working in the field of nanoscience and nanotechnology, are cordially invited to contribute original research papers to this Special Issue of Molecules. This issue is multidisciplinary and welcomes submissions across physical, chemical, biological, materials, and engineering sciences.

Dr. Grzegorz Nowaczyk
Dr. Dorota Katarzyna Flak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional nanomaterials
  • nanomaterials for energy conversion and storage devices
  • hard coatings
  • nanosensors
  • nanomaterials for catalysis
  • nanomembranes and nanofilters
  • nanodevices
  • nanobiomedicine
  • bio-imaging; drug delivery
  • nanotoxicology
  • nanomaterials in regenerative medicine
  • green nanotechnology
  • theory, modelling and design of nanomaterials and nanodevices

Published Papers (4 papers)

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Research

32 pages, 8059 KiB  
Article
Raman Spectroscopy and Imaging Studies of Human Digestive Tract Cells and Tissues—Impact of Vitamin C and E Supplementation
by Karolina Beton-Mysur and Beata Brozek-Pluska
Molecules 2023, 28(1), 137; https://doi.org/10.3390/molecules28010137 - 24 Dec 2022
Cited by 4 | Viewed by 2278
Abstract
Cancers of digestive tract such as colorectal cancer (CRC) and gastric cancer (GC) are the most commonly detected types of cancer worldwide and their origin can be associated with oxidative stress conditions. Commonly known and followed antioxidants, such as vitamin C and E, [...] Read more.
Cancers of digestive tract such as colorectal cancer (CRC) and gastric cancer (GC) are the most commonly detected types of cancer worldwide and their origin can be associated with oxidative stress conditions. Commonly known and followed antioxidants, such as vitamin C and E, are widely considered as potential anti-cancer agents. Raman spectra have great potential in the biochemical characterization of matter based on the fact that each molecule has its own unique vibrational properties. Raman spectroscopy allows to precisely characterize components (proteins, lipids, nucleic acids). The paper presents the application of the Raman spectroscopy technique for the analysis of tissue samples and cells of the human colon and stomach. The main goal of this study is to show the differences between healthy and cancerous tissues from the human digestive tract and human normal and cancer colon and gastric cell lines. The paper presents the spectroscopic characterization of normal colon cells, CCD-18 Co, in physiological and oxidative conditions and effect of oxidative injury of normal colon cells upon supplementation with vitamin C at various concentrations based on Raman spectra. The obtained results were related to the Raman spectra recorded for human colon cancer cells—CaCo-2. In addition, the effect of the antioxidant in the form of vitamin E on gastric cancer cells, HTB-135, is presented and compared with normal gastric cells—CRL-7869. All measured gastric samples were biochemically and structurally characterized by means of Raman spectroscopy and imaging. Statistically assisted analysis has shown that normal, ROS injured and cancerous human gastrointestinal cells can be distinguished based on their unique vibrational properties. ANOVA tests, PCA (Principal Component Analysis) and PLSDA (Partial Least Squares Discriminant Analysis) have confirmed the main role of nucleic acids, proteins and lipids in differentiation of human colon and stomach normal and cancer tissues and cells. The conducted research based on Raman spectra proved that antioxidants in the form of vitamin C and E exhibit anti-cancer properties. In consequence, conducted studies proved that label-free Raman spectroscopy may play an important role in clinical diagnostic differentiation of human normal and cancerous gastrointestinal tissues and may be a source of intraoperative information supporting histopathological analysis. Full article
(This article belongs to the Special Issue NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine)
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18 pages, 1947 KiB  
Article
Electrochemical Sensors Based on Au Nanoparticles Decorated Pyrene-Reduced Graphene Oxide for Hydrazine, 4-Nitrophenol and Hg2+ Detection in Water
by Alma Mejri, Giacomo Mandriota, Hamza Elfil, Maria Lucia Curri, Chiara Ingrosso and Abdelmoneim Mars
Molecules 2022, 27(23), 8490; https://doi.org/10.3390/molecules27238490 - 2 Dec 2022
Cited by 2 | Viewed by 1848
Abstract
Monitoring hazardous chemical compounds such as hydrazine (N2H4), 4-nitrophenol (4-NP) and Hg2+ in natural water resources is a crucial issue due to their toxic effects on human health and catastrophic impact on the environment. Electrochemical nanostructured platforms integrating [...] Read more.
Monitoring hazardous chemical compounds such as hydrazine (N2H4), 4-nitrophenol (4-NP) and Hg2+ in natural water resources is a crucial issue due to their toxic effects on human health and catastrophic impact on the environment. Electrochemical nanostructured platforms integrating hybrid nanocomposites based on graphene derivatives and inorganic nanoparticles (NPs) are of great interest for such a purpose. In this work, disposable screen-printed carbon electrodes (SPCEs) have been modified with a hybrid nanocomposite formed by reduced graphene oxide (RGO), functionalized by 1-pyrene carboxylic acid (PCA), and decorated by colloidal Au NPs. These hybrid platforms have been tested for the electrocatalytic detection of N2H4 and 4-NP by differential pulse voltammetry and have been modified with an electropolymerized film of Hg2+ ions imprinted polycurcumin for the electroanalytical detection of Hg2+ by DPV. LODs, lower and in line with the lowest ones reported for state-of-the-art electrochemical sensors, integrating similar Au-graphene < nanocomposites, have been estimated. Additionally, good repeatability, reproducibility, and storage stability have been assessed, as well as a high selectivity in the presence of a 100-fold higher concentration of interfering species. The applicability of the proposed platforms for the detection of the compounds in real complex matrices, such as tap and river water samples, has been effectively demonstrated. Full article
(This article belongs to the Special Issue NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine)
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Graphical abstract

18 pages, 3192 KiB  
Article
Molecular Dynamics and Structure of Poly(Methyl Methacrylate) Chains Grafted from Barium Titanate Nanoparticles
by Aleksandra Wypych-Puszkarz, Onur Cetinkaya, Jiajun Yan, Ruslana Udovytska, Jarosław Jung, Jacek Jenczyk, Grzegorz Nowaczyk, Stefan Jurga, Jacek Ulański, Krzysztof Matyjaszewski, Joanna Pietrasik and Marcin Kozanecki
Molecules 2022, 27(19), 6372; https://doi.org/10.3390/molecules27196372 - 27 Sep 2022
Cited by 4 | Viewed by 1944
Abstract
Core−shell nanocomposites comprising barium titanate, BaTiO3 (BTO), and poly(methyl methacrylate) (PMMA) chains grafted from its surface with varied grafting densities were prepared. BTO nanocrystals are high-k inorganic materials, and the obtained nanocomposites exhibit enhanced dielectric permittivity, as compared to neat PMMA, and [...] Read more.
Core−shell nanocomposites comprising barium titanate, BaTiO3 (BTO), and poly(methyl methacrylate) (PMMA) chains grafted from its surface with varied grafting densities were prepared. BTO nanocrystals are high-k inorganic materials, and the obtained nanocomposites exhibit enhanced dielectric permittivity, as compared to neat PMMA, and a relatively low level of loss tangent in a wide range of frequencies. The impact of the molecular dynamics, structure, and interactions of the BTO surface on the polymer chains was investigated. The nanocomposites were characterized by broadband dielectric and vibrational spectroscopies (IR and Raman), transmission electron microscopy, differential scanning calorimetry, and nuclear magnetic resonance. The presence of ceramic nanoparticles in core–shell composites slowed down the segmental dynamic of PMMA chains, increased glass transition temperature, and concurrently increased the thermal stability of the organic part. It was also evidenced that, in addition to segmental dynamics, local β relaxation was affected. The grafting density influenced the self-organization and interactions within the PMMA phase, affecting the organization on a smaller size scale of polymeric chains. This was explained by the interaction of the exposed surface of nanoparticles with polymer chains. Full article
(This article belongs to the Special Issue NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine)
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12 pages, 2566 KiB  
Article
pH and Reduction Dual-Responsive Nanogels as Smart Nanocarriers to Resist Doxorubicin Aggregation
by Ali Maruf, Małgorzata Milewska, Anna Lalik and Ilona Wandzik
Molecules 2022, 27(18), 5983; https://doi.org/10.3390/molecules27185983 - 14 Sep 2022
Cited by 6 | Viewed by 1693
Abstract
The use of smart nanocarriers that can modulate therapeutic release aided by biological cues can prevent undesirable cytotoxicity caused by the premature release of cytotoxic drugs during nanocarrier circulation. In this report, degradable nanocarriers based on pH/reduction dual-responsive nanogels were synthesized to encapsulate [...] Read more.
The use of smart nanocarriers that can modulate therapeutic release aided by biological cues can prevent undesirable cytotoxicity caused by the premature release of cytotoxic drugs during nanocarrier circulation. In this report, degradable nanocarriers based on pH/reduction dual-responsive nanogels were synthesized to encapsulate doxorubicin hydrochloride (DOX) and specifically boost the release of DOX in conditions characteristic of the cancer microenvironment. Nanogels containing anionic monomer 2-carboxyethyl acrylate (CEA) and N,N′-bis(acryloyl)cystamine (CBA) as a degradable crosslinker have been successfully synthesized via photoinitiated free radical polymerization. The loading process was conducted after polymerization by taking advantage of the electrostatic interaction between the negatively charged nanogels and the positively charged DOX. In this case, a high drug loading capacity (DLC) of up to 27.89% was achieved. The entrapment of DOX into a nanogel network could prevent DOX from aggregating in biological media at DOX concentrations up to ~160 µg/mL. Anionic nanogels had an average hydrodynamic diameter (dH) of around 90 nm with a negative zeta (ζ) potential of around −25 mV, making them suitable for targeting cancer tissue via the enhanced permeation effect. DOX-loaded nanogels formed a stable dispersion in different biological media, including serum-enriched cell media. In the presence of glutathione (GSH) and reduced pH, drug release was enhanced, which proves dual responsivity. An in vitro study using the HCT 116 colon cancer cell line demonstrated the enhanced cytotoxic effect of the NG-CBA/DOX-1 nanogel compared to free DOX. Taken together, pH/reduction dual-responsive nanogels show promise as drug delivery systems for anticancer therapy. Full article
(This article belongs to the Special Issue NanoTech Poland 2022—Nanotechnology in Energy, Electronics, Photonics, Environment and Biomedicine)
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