molecules-logo

Journal Browser

Journal Browser

Therapy of Neurodegenerative Diseases in Medicinal Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2151

Special Issue Editor


E-Mail Website
Guest Editor
Department of Anatomy and Cell Biology, Taipei Medical University, Taipei, Taiwan
Interests: neurodegenerative diseases; sleep medicine; melatonin research; oral pathology; metabolic dysfunction; nano-biotechnology

Special Issue Information

Dear Colleagues,

With the coming of the aging society, neurodegenerative diseases have become one of the most urgent problems costing huge financial and moral expenses in numerous countries. Over the past few decades, limited advance has been made through neuroscience research in which current strategies for the treatment of neurodegenerative diseases are mostly symptomatic without effectively halting the disease progression. Therefore, new drugs or biomedical agents with higher bioactivity and safety profile are thus warranted to develop by multidisciplinary cooperation to block the disease progression and restore all the compromised functions. In this Special Issue, we aim to provide a multidisciplinary platform that offer researchers dedicated in this field to demonstrate their novel strategies against neurodegenerative diseases or to explore the underlying mechanisms participated in the disease progression. These strategies may include, but not limit to, repurposing certain antibiotics for treating neurodegenerative diseases, developing anti-oxidative substance by nano-biomaterials, deriving anti-inflammatory agents from human platelet lysate, utilizing sensory stimulation to correct emotional phenotypes, or repairing neuronal function with advanced cell therapy, etc. Both original articles and reviews are welcome. In addition, articles that depicting the innovative approaches developed to resolve the deficits that are likely to have neurodegenerative origins (such as sleep problem or oropharyngeal dysphagia) are also welcome.     

I am looking forward to receiving your contributions.

Dr. Hung-Ming Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • therapeutic strategy
  • systemic dysfunction
  • cellular mechanisms
  • drug repurposing
  • multidisciplinary approaches

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

12 pages, 4554 KiB  
Article
Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation
by Chiung-Hui Liu, Ying-Jui Ho, Che-Yu Wang, Chao-Chun Hsu, Yin-Hung Chu, Min-Yen Hsu, Shiu-Jau Chen, Wen-Chuan Hsiao and Wen-Chieh Liao
Molecules 2023, 28(9), 3742; https://doi.org/10.3390/molecules28093742 - 26 Apr 2023
Cited by 1 | Viewed by 1763
Abstract
Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary. Several studies have indicated that the chondroitin sulfate (CS) chains on versican have several possible functions beyond [...] Read more.
Versican is a chondroitin sulfate proteoglycan (CSPG), which deposits in perineurium as a physical barrier and prevents the growth of axons out of the fascial boundary. Several studies have indicated that the chondroitin sulfate (CS) chains on versican have several possible functions beyond the physical barrier, including the ability to stabilize versican core protein in the extracellular matrix. As chondroitin sulfate synthase 1 (Chsy1) is a crucial enzyme for CS elongation, we hypothesized that in vivo knockdown of Chsy1 at peripheral nerve lesion site may decrease CS and versican accumulation, and result in accelerating neurite regeneration. In the present study, end-to-side neurorrhaphy (ESN) in Wistar rats was used as an in vivo model of peripheral nerve injury to evaluate nerve regeneration after surgical intervention. The distribution and expression of versican and Chsy1 in regenerating axons after ESN was studied using confocal microscopy and western blotting. Chsy1 was silenced at the nerve lesion (surgical) site using in vivo siRNA transfection. The results indicated that Chsy1 was successfully silenced in nerve tissue, and its downregulation was associated with functional recovery of compound muscle action potential. Silencing of Chsy1 also decreased the accumulation of versican core protein, suggesting that transient treating of Chsy1-siRNA may be an alternative and an effective strategy to promote injured peripheral nerve regeneration. Full article
(This article belongs to the Special Issue Therapy of Neurodegenerative Diseases in Medicinal Chemistry)
Show Figures

Graphical abstract

Back to TopTop