Nitrogen Heterocycles in Medicinal Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 64858
Special Issue Editors
Interests: drug discovery; medicinal chemistry; synthesis of heterocyclic compounds; antitumor agents, kinases; marine alkaloids analogs; anti-fibrotic agents
Interests: drug discovery; medicinal chemistry; synthesis of heterocyclic compounds; organic synthesis; new synthetic methodologies; anti-inflammatory agents; enzyme inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is a great pleasure and honor for us to invite you to contribute to the Special Issue entitled “Nitrogen heterocycles in Medicinal Chemistry”.
Nitrogen heterocycles represent a highly important class of compounds that are widespread in medicinal chemistry, receiving special attention in drug discovery. These heterocyclic rings are common structural units in many natural or synthetic agents and approximately 60% of FDA-approved drugs contain a nitrogen heterocycle in their structure.
They exhibit a very wide range of biological activities as antibiotic, antibacterial, antifungal, anticancer, anticonvulsant, anti-HIV, anti-inflammatory, analgesic, antitubercular, and antimalarial agents. Moreover, they also have applications as fungicides, herbicides, anticorrosives, agrochemicals, antioxidants, and play an important role in biochemical processes because they are key elements of DNA, RNA, and coenzymes.
Despite the extensive literature on N-heterocycles synthesis, there is great interest in the development of more innovative and efficient synthetic methodologies to obtain new chemical entities.
This Special Issue will accept original research papers and high-quality reviews in the fields of medicinal chemistry, organic chemistry, biochemistry, and pharmacology. The topic of the Special Issue will be focused on the drug design, new synthetic approaches, biosynthesis, isolation, and biological activity of new nitrogen heterocycle derivatives.
Dr. Anna Carbone
Dr. Fabio Bertozzi
Guest Editors
Manuscript Submission Information
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Keywords
- Nitrogen heterocycles
- Drug discovery
- Medicinal chemistry
- New synthetic methodologies
- Biosynthesis
- Isolation
- Biological activity
- Natural compounds
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