Nucleosides: Synthesis and Antiviral Activity
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 10570
Special Issue Editor
Interests: pericyclic reactions; 1,3-dipolar cycloadditions; hetero diels-alder reactions; antivirals; catalysis; polymers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For the last few decades, viral infectious diseases have continued to be a major health concern worldwide, causing relevant epidemiological, financial, and logistical implications. The use of many conventional drugs is hampered by a lack of efficacy, emergence of resistance, adverse effects, and high costs. Thus, new strategies and therapeutic alternatives are constantly needed. Nucleosides are fundamental building blocks of biological systems that show a wide range of biological activities. Consequently, extensive modifications have been made to both the heterocyclic base and the sugar moiety in order to avoid the drawbacks shown by nucleosides or analogues in certain applications, mainly due to enzymatic degradations. The design and synthesis of molecules for the fight against aggressive and potentially fatal diseases, also including cancer and bacterial infections, remain important challenges. Chemical literature in this field is constantly growing and reports extremely valuable synthetic strategies that apply old and new chemical reactions to prepare a wide variety of nucleosides and analogs in high yields in few synthetic steps and with remarkably lower costs.
This Special Issue aims to attract contributions on all the aspects concerning the synthesis, through various and different strategies, of classical nucleosides, carbocyclic nucleoside, and analogs. These results can be considered fully consistent if in vitro biological evaluations of the synthetized compounds are also reported. This will be the challenge to further exploring the range of biological effects and potential applications as antivirals of brand-new compounds.
Prof. Dr. Paolo Quadrelli
Guest Editor
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Keywords
- Nucleosides
- Nucleoside analogues
- Synthetic strategy
- Antivirals
- Biological evaluation
- Structure activity relationship
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