molecules-logo

Journal Browser

Journal Browser

Oxidative Stress and Disease

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 4876

Special Issue Editor


E-Mail Website
Guest Editor
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404332, Taiwan
Interests: neuropsychopharmacology; cognitive neuroscience

Special Issue Information

Dear Colleagues,

Oxidative stress is implicated in many diseases, including mental disorders, Alzheimer’s disease, cancer, atherosclerosis, and chronic obstructive pulmonary disease. Although numerous small molecules regarded as antioxidants have revealed therapeutic potential in preclinical studies, clinical trial results have not yet been favorable. A better elucidation of the mechanisms through which antioxidants exert activity may provide biomarkers and effective/individualized therapeutic approaches that lead to greater clinical success. This Special Issue entitled “Oxidative Stress and Disease” aims to update the relationships between oxidative stress, redox signaling, and diseases, the mechanisms of oxidative stress contributing to time-dynamic pathology, how antioxidants act and work, and how antioxidant effects can be enhanced through physiological signaling, dietary supplements, and potential/novel pharmaceutical intervention.

Prof. Dr. Hsien-Yuan Lane
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oxidative stress
  • Schizophrenia
  • Depression
  • Alzheimer’s disease
  • Cancer
  • Atherosclerosis
  • Chronic Obstructive pulmonary disease
  • Antioxidants
  • Redox signaling
  • Pharmaceutical intervention

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

18 pages, 865 KiB  
Review
Oxidative Stress, Genomic Integrity, and Liver Diseases
by Nanthini Sadasivam, Yu-Ji Kim, Kamalakannan Radhakrishnan and Don-Kyu Kim
Molecules 2022, 27(10), 3159; https://doi.org/10.3390/molecules27103159 - 15 May 2022
Cited by 40 | Viewed by 4482
Abstract
Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants. This imbalance can lead to malfunction or structure modification [...] Read more.
Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants. This imbalance can lead to malfunction or structure modification of major cellular molecules such as lipids, proteins, and DNAs. During oxidative stress conditions, DNA and protein structure modifications can lead to various diseases. Various antioxidant-specific gene expression and signal transduction pathways are activated during oxidative stress to maintain homeostasis and to protect organs from oxidative injury and damage. The liver is more vulnerable to oxidative conditions than other organs. Antioxidants, antioxidant-specific enzymes, and the regulation of the antioxidant responsive element (ARE) genes can act against chronic oxidative stress in the liver. ARE-mediated genes can act as the target site for averting/preventing liver diseases caused by oxidative stress. Identification of these ARE genes as markers will enable the early detection of liver diseases caused by oxidative conditions and help develop new therapeutic interventions. This literature review is focused on antioxidant-specific gene expression upon oxidative stress, the factors responsible for hepatic oxidative stress, liver response to redox signaling, oxidative stress and redox signaling in various liver diseases, and future aspects. Full article
(This article belongs to the Special Issue Oxidative Stress and Disease)
Show Figures

Figure 1

Back to TopTop