Recent Advances in Peptide-Lead Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3612
Special Issue Editor
Interests: medicinal chemistry; bioorganic chemistry; chemical biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Peptides represent an attractive class of molecules for the design of new drugs, lead structures, drug carriers, and excipients. Recent developments in peptide synthesis techniques and high-throughput screening platforms have created enthusiasm and interest in the design and discovery of novel peptides for a broad range of biological and pharmacological applications. Advances in peptide engineering have helped to overcome traditional limitations in peptide drug development, such as poor systemic stability, rapid clearance, and low binding affinities to biological targets. Currently, there are nearly one hundred peptide-based drug candidates in clinical trials, a dramatic increase compared to the number of those under study a decade ago. These developments signal a “second wave” in peptide drug development.
Over the past decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs and how this class of compounds can be an excellent complement or even a preferable alternative to small-molecule and biological therapeutics.
This Special Issue of Molecules welcomes submissions of review and research articles in the field of peptide drug discovery and development.
Prof. Dr. Hirokazu Tamamura
Guest Editor
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Keywords
- Therapeutic peptides
- Peptide synthesis
- Drug development
- Drug targeting
- Antimicrobial peptides
- Peptides and Alzheimer’s disease
- Peptides and metabolic syndrome
- Peptides and cancer
- Peptides as shuttles
- Peptide-based drug delivery
- Peptide-based vaccines
- Peptide–drug conjugates
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