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Multifunctional Nanomaterials for Bioapplications, 2nd Edition

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Special Issue Information

Dear Colleagues,

Multifunctional nanomaterials refer to materials that are hybridized by two or more substances at the nano-scale, including nano-ceramic materials, nano-magnetic materials, nano-carbon materials and carbon nanotubes, among others. The obtained composite nano-materials not only have the properties of a small size effect, surface effect and quantum size effect of nano-materials, but also combine the rigidity, dimensional stability and thermal stability of inorganic materials with the toughness, easy processability and dielectric properties of polymers, so as to produce new materials. Nano-materials show specific many physicochemical properties due to their preparation and size characteristics, which show great application value in the field of biomedicine, including imaging, biosensor, drug loading, anti-tumor, antibacterial, PDT, PTT and regeneration. With the development of nanotechnology, cheap, mild and simple preparation and assembly methods provide greater feasibility for obtaining reasonable multifunctional nano-materials to be applied in the biomedical field. As a more comprehensive, biosafe and effective nano-platform, multifunctional nano-materials show better application prospects.

Prof. Dr. Libing Liu
Guest Editor

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Related Special Issue

Published Papers (1 paper)

Research

17 pages, 3095 KiB

Open AccessArticle

Supramolecular Switch for the Regulation of Antibacterial Efficacy of Near-Infrared Photosensitizer

by Yu-Na Jiang, Manqi Tan, Chenglong He, Jiaxi Wang, Yi Wei, Ningning Jing, Bing Wang, Fang Yang, Yujie Zhang and Meng Li

Molecules 2024, 29(5), 1040; https://doi.org/10.3390/molecules29051040 - 28 Feb 2024

Viewed by 594

Abstract

The global antibiotic resistance crisis has drawn attention to the development of treatment methods less prone to inducing drug resistance, such as antimicrobial photodynamic therapy (aPDT). However, there is an increasing demand for new photosensitizers capable of efficiently absorbing in the near-infrared (NIR) region, enabling antibacterial treatment in deeper sites. Additionally, advanced strategies need to be developed to avert drug resistance stemming from prolonged exposure. Herein, we have designed a conjugated oligoelectrolyte, namely TTQAd, with a donor-acceptor-donor (D-A-D) backbone, enabling the generation of reactive oxygen species (ROS) under NIR light irradiation, and cationic adamantaneammonium groups on the side chains, enabling the host-guest interaction with curcubit[7]uril (CB7). Due to the amphiphilic nature of TTQAd, it could spontaneously form nanoassemblies in aqueous solution. Upon CB7 treatment, the positive charge of the cationic adamantaneammonium group was largely shielded by CB7, leading to a further aggregation of the nanoassemblies and a reduced antibacterial efficacy of TTQAd. Subsequent treatment with competitor guests enables the release of TTQAd and restores its antibacterial effect. The reversible supramolecular switch for regulating the antibacterial effect offers the potential for the controlled release of active photosensitizers, thereby showing promise in preventing the emergence of drug-resistant bacteria. Full article

(This article belongs to the Special Issue Multifunctional Nanomaterials for Bioapplications, 2nd Edition)

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