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Synthesis and Application of Anticancer Inhibitors

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5313

Special Issue Editor

School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
Interests: cancer; metastasis; high-throughput screening; immune microenvironment; drug discovery; pharmacology of anti-neoplastic drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to attract high-quality papers focused on the design, synthesis, and molecular mechanism of action of novel antitumor molecules. We are especially interested in articles on the discovery of novel oncological targets based on biologic and genotypic context, and those that rationally design effective molecules to illustrate the relationship between the chemical structure and the biological activity. The potential anticancer inhibitors for the Special Issue include, but are not limited to, traditional chemotherapeutic agents, targeted therapies and immunomodulators, small molecules, peptides, and polysaccharides. We welcome both original and review articles.

Dr. Peiju Qiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antitumor molecules
  • synthesis
  • molecular mechanism
  • chemotherapeutic agents
  • targeted therapies
  • immunomodulator

Published Papers (2 papers)

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Research

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20 pages, 16514 KiB  
Article
A Triazaspirane Derivative Inhibits Migration and Invasion in PC3 Prostate Cancer Cells
by Javier de Jesús Vasconcelos-Ulloa, Victor García-González, Benjamín Valdez-Salas, José Gustavo Vázquez-Jiménez, Ignacio Rivero-Espejel, Raúl Díaz-Molina and Octavio Galindo-Hernández
Molecules 2023, 28(11), 4524; https://doi.org/10.3390/molecules28114524 - 2 Jun 2023
Cited by 1 | Viewed by 1705
Abstract
Cancer is a serious health problem due to the complexity of establishing an effective treatment. The purpose of this work was to evaluate the activity of a triazaspirane as a migration and invasion inhibitor in PC3 prostatic tumor cells through a possible negative [...] Read more.
Cancer is a serious health problem due to the complexity of establishing an effective treatment. The purpose of this work was to evaluate the activity of a triazaspirane as a migration and invasion inhibitor in PC3 prostatic tumor cells through a possible negative regulation of the FAK/Src signal transduction pathway and decreased secretion of metalloproteinases 2 and 9. Molecular docking analysis was performed using Moe 2008.10 software. Migration (wound-healing assay) and invasion (Boyden chamber assay) assays were performed. In addition, the Western blot technique was used to quantify protein expression, and the zymography technique was used to observe the secretion of metalloproteinases. Molecular docking showed interactions in regions of interest of the FAK and Src proteins. Moreover, the biological activity assays demonstrated an inhibitory effect on cell migration and invasion, an important suppression of metalloproteinase secretion, and a decrease in the expression of p-FAK and p-Src proteins in treated PC3 cells. Triazaspirane-type molecules have important inhibitory effects on the mechanisms associated with metastasis in PC3 tumor cells. Full article
(This article belongs to the Special Issue Synthesis and Application of Anticancer Inhibitors)
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Review

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35 pages, 3494 KiB  
Review
Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins
by Lu Jin, Zhijun Song, Fang Cai, Lijun Ruan and Renwang Jiang
Molecules 2023, 28(1), 302; https://doi.org/10.3390/molecules28010302 - 30 Dec 2022
Cited by 8 | Viewed by 3083
Abstract
Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these [...] Read more.
Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these molecules were performed to afford a variety of derivatives, which offered optimized anti-tumor activity. This review summarized up to date reports on natural occurring podophyllotoxins and their sources, structural modification and biological activities. Special attention was paid to both structural modification and optimized antitumor activity. It was noteworthy that etoposide, a derivative of podophyllotoxin, could prevent cytokine storm caused by the recent SARS-CoV-2 viral infection. Full article
(This article belongs to the Special Issue Synthesis and Application of Anticancer Inhibitors)
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