Diversity Oriented Synthesis 2016
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Diversity".
Deadline for manuscript submissions: closed (30 July 2016) | Viewed by 26446
Special Issue Editor
Interests: drug discovery; organic synthesis; medicinal chemistry; molecular imaging; diversity-oriented synthesis; peptidomimetics; chemoinformatics; enzyme inhibitors; angiogenesis; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since its introduction, Diversity-Oriented Synthesis (DOS) has become a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways, and to provide a larger array of the chemical space in drug discovery and chemical biology issues. This strategy combines the generation of a functionalized precursor with further synthetic elaborations, in order to generate the maximum diversity and complexity from simple starting material, thus achieving molecules that differ not only for the appendages, as in traditional combinatorial chemistry, but, also, in the stereochemistry and molecular skeleton. Several DOS approaches have been proposed thus far, as divergent pathways consisting of a complexity-generating reaction followed by cyclization steps and appendage diversity, or as synthetic schemes for generating different cyclic structures through the build/couple/pair approach.
The possibility of creating new highly-diverse and complex molecular platforms, and the achievement of hundreds to thousands to millions of compounds is producing significant advances in chemical biology and drug discovery. This is mainly due to the improvement of the quality of chemical libraries, which are more stereochemically rich and structurally complex. DOS molecular collections are being applied in high-throughput screening, phenotypic assays and chemical genetics studies, leading to the discovery of both new targets and new lead compounds.
To date, many research contributions regarding diversity-oriented synthesis, covering the organic and medicinal chemistry fields, have appeared in the literature. Nevertheless, this research area is quite vibrant and many research groups are active in this field.
We invite the submission of research articles or review papers on advances in diversity-oriented synthesis through the elaboration of novel molecular scaffolds, and innovative divergent synthetic pathways. Papers related to new technologies enabling library development or to chemoinformatic characterization of DOS collections are also welcome.
Prof. Dr. Andrea Trabocchi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Small molecules
- Building blocks
- Molecular diversity
- Combinatorial chemistry
- Drug discovery
- Chemical biology
- High-throughput screening
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.