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Recent Advances in Metal-Catalyzed Domino Reactions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (20 July 2020) | Viewed by 3188

Special Issue Editor


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Guest Editor
Universite de Strasbourg, Laboratoire d’Innovation Thérapeutique, UMR 7200 CNRS, Strasbourg, France
Interests: organometallic catalysis; C–C or C–Heteroatome bond formation; complex molecules; polycyclic compounds; heterocycles; domino reaction; palladium and gold catalysis

Special Issue Information

Dear Colleagues,

A challenging area in chemistry is the development of reactions allowing atom and step efficiency to access new synthetic structures. A particularly promising strategy is to trigger domino reactions that convert simple starting materials into highly sophisticated targets by creating several bonds in a one-pot operation. Moreover, the use of transition in metal-catalyzed transformations as part of a domino process favors highly selective reactions due to the preorganization of the reactive intermediates around the metallic center. The present Special Issue intends to highlight updated contributions involving metal-catalyzed domino reactions. Communications, full papers, and reviews by experts in the field are welcome.

Dr. Gaëlle Blond
Guest Editor

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Keywords

  • Domino reactions
  • Cascade reactions
  • Atom and step efficiency
  • Polycycles
  • Heterocycles
  • Complex molecules
  • Organometallic catalysis

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Published Papers (1 paper)

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Research

12 pages, 5128 KiB  
Communication
Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis
by Marie Ruch, Nicolas Brach, Roméric Galéa, Patrick Wagner and Gaëlle Blond
Molecules 2020, 25(21), 4976; https://doi.org/10.3390/molecules25214976 - 27 Oct 2020
Cited by 6 | Viewed by 2917
Abstract
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran [...] Read more.
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center are formed. Full article
(This article belongs to the Special Issue Recent Advances in Metal-Catalyzed Domino Reactions)
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