Medicinal Chemistry Studies of Neglected Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 19863
Special Issue Editor
Interests: posttranslational modifications; drug discovery for neglected tropical diseases; cAMP-regulated pathways in apicomplexan parasites and kinetoplastids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The reemergence of neglected tropical diseases, in particular in Subsaharian Africa due to unique resistance mechanisms of parasites, provides a challenge for medicinal chemistry in the future. Novel compounds containing new scaffolds might offer one way to tackle the problem. Secondly, specificity of parasitic target inhibition is necessary, in particular when a paralogue of the target is present in the human host. Thus, the introduction of chemical modifications into a scaffold might be of interest for lead optimization. Thirdly, rapid and robust analytical assays are necessary to predict the efficacy of a small molecule. Currently, the available big data for drug targets will facilitate the design of specific inhibitors on the basis of medicinal chemistry. Preclinical studies presenting in vitro or in vivo technologies are of further interest. Please, feel free to contact Lucy Chai ([email protected]) if you would like to contribute to this special issue.
Prof. Dr. Annette Kaiser
Guest Editor
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Keywords
- novel scaffolds
- target specificity
- chemical modifications for lead optimization
- rapid and robust analytical and biological assays
- incorporation of big data for target optimization
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