Natural Products: Isolation, Pharmacomodulation and Optimization for Hit and Lead Identification
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 371
Special Issue Editor
Special Issue Information
Dear Colleagues,
Although new approaches to drug discovery, such as combinatorial chemistry and computer‐based molecular modeling design mean that many final pharmaceuticals are intended to be made by synthetic chemistry, the majority of modern drugs are mainly derived from natural products or derived from natural lead compounds. In this context and in many cases, the bioactive compound isolated from plants is not always the developed drug because many parameters need to be optimized to develop a successful drug. To reach this end, the hemi-synthesis and pharmacomodulation of bioactive compounds isolated from plants are crucial steps toward the creation of a drug candidate.
The aim of this Special Issue is to collect review and original research articles dealing with the isolation of original bioactive compounds and the design and synthesis of analogs through pharmacomodulation including case studies. This issue will be of interest for a large panel of scientists working in the field of natural products as hits and leads for drug development.
Prof. Ahcène Boumendjel
Guest Editor
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Keywords
- Natural products
- Pharmacognosy
- From hit to lead
- Structure–activity relationships
- Natural products in medicinal chemistry
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