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Perspectives in Nanotechnology Based Innovative Applications in Diagnosis and Treatment of Infectious and Non-infectious Disease

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5511

Special Issue Editors


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Guest Editor
Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada
Interests: laser; two photon spectroscopy; photoacoustic Imaging; surface enhanced raman spectroscopy; ultrasound; cancer detection and therapy; nanotechnology; simulations; gold nanoparticles

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Guest Editor
Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada
Interests: nanotechnology; theoretical chemistry and simulations; modelling; nano and microbubbles; contrast agents; ultrasound

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Guest Editor
Istituto Italiano di Tecnologia, IIT@CRIB, Largo Barsanti e Matteucci 53, 80125 Napoli, Italy
Interests: nanomaterials; nanomedicine; green chemistry; cytotoxicity; cancer therapy; drug delivery; ultrasound

Special Issue Information

Dear Colleagues,

Nearly all scientific and technological areas are feeling the benefits of the introduction of nanotechnology through an integrated approach. The human population in today’s world suffers from several diseases and the available medication and therapies are found to be insufficient both for diagnosis and complete cure. Around three decades ago, the term “nanomedicine” was introduced when it was found that the convergence of nanotechnology and medicine can revolutionize the way we detect and treat damage to the human body and diseases in the future. Some techniques, such targeted drug delivery and gene therapy or the early detection and diagnosis of cancer, are already in use while others are at various stages of testing and making remarkable progress toward becoming a reality. Our main focus is on engineered nanoparticles that hold significant promise to improve disease diagnosis and treatment specificity. A variety of nanomaterials, such as micelles, liposomes, polymeric nanoparticles, lipid-based nanoparticles, carbon-based nanoparticles, metal, and ceramic nanoparticles, have displayed enhanced performance in diagnosing and improving the treatment of various diseases, as well as delivering drugs and genes in a targeted way directly at the site of the disease. This reduces damage to healthy tissue many-fold and also allows for the early detection of disease. This Special Issue aims to discuss and present recent advances in nanomedicine in the treatment, diagnosis, and detection of all types of infectious and non-infectious diseases around the globe. The editors are pleased to invite high-quality, communications, original research articles (experiments, theoretical calculations, and modelling), reviews, and mini reviews from different research fields that provide the latest developments, new insights, protocols, results, and greater understanding in this broad field.

Dr. Sathiyamoorthy Krishnan
Dr. Amin Jafari Sojahrood
Dr. Anshuman Jakhmola
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomedicine
  • targeted drug delivery
  • nanoparticles
  • cancer therapy
  • biocompatibility
  • photothermal therapy
  • nanorobotics
  • nano vaccines

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Published Papers (2 papers)

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Research

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19 pages, 3470 KiB  
Article
Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes
by Myriam Lamrayah, Capucine Phelip, Renaud Rovera, Céline Coiffier, Nora Lazhar, Francesca Bartolomei, Evelyne Colomb, Bernard Verrier, Claire Monge and Sophie Richard
Molecules 2023, 28(12), 4778; https://doi.org/10.3390/molecules28124778 - 15 Jun 2023
Cited by 2 | Viewed by 1637
Abstract
Vaccine technology is still facing challenges regarding some infectious diseases, which can be addressed by innovative drug delivery systems. In particular, nanoparticle-based vaccines combined with new types of adjuvants are actively explored as a platform for improving the efficacy and durability of immune [...] Read more.
Vaccine technology is still facing challenges regarding some infectious diseases, which can be addressed by innovative drug delivery systems. In particular, nanoparticle-based vaccines combined with new types of adjuvants are actively explored as a platform for improving the efficacy and durability of immune protection. Here, biodegradable nanoparticles carrying an antigenic model of HIV were formulated with two combinations of poloxamers, 188/407, presenting or not presenting gelling properties, respectively. The study aimed to determine the influence of poloxamers (as a thermosensitive hydrogel or a liquid solution) on the adaptive immune response in mice. The results showed that poloxamer-based formulations were physically stable and did not induce any toxicity using a mouse dendritic cell line. Then, whole-body biodistribution studies using a fluorescent formulation highlighted that the presence of poloxamers influenced positively the dissemination profile by dragging nanoparticles through the lymphatic system until the draining and distant lymph nodes. The strong induction of specific IgG and germinal centers in distant lymph nodes in presence of poloxamers suggested that such adjuvants are promising components in vaccine development. Full article
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Review

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15 pages, 1857 KiB  
Review
Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges
by Marta J. Woźniak-Budych, Katarzyna Staszak and Maciej Staszak
Molecules 2023, 28(18), 6687; https://doi.org/10.3390/molecules28186687 - 18 Sep 2023
Cited by 25 | Viewed by 3541
Abstract
Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and copper oxide nanoparticles stand out as promising candidates for a multitude of medical applications. This article aims to provide contemporary insights into [...] Read more.
Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and copper oxide nanoparticles stand out as promising candidates for a multitude of medical applications. This article aims to provide contemporary insights into the perspectives and challenges regarding the use of copper and copper oxide nanoparticles in medicine. It summarises the biomedical potential of copper-based nanoformulations, including the progress of early-stage research, to evaluate and mitigate the potential toxicity of copper nanomaterials. The discussion covers the challenges and prospects of copper-based nanomaterials in the context of their successful clinical translation. The article also addresses safety concerns, emphasizing the need for toxicity assessments of nanomedicines. However, attention is needed to solve the current challenges such as biocompatibility and controlled release. Ongoing research and collaborative efforts to overcome these obstacles are discussed. This analysis aims to provide guidance for the safe and effective integration of copper nanoparticles into clinical practice, thereby advancing their medical applications. This analysis of recent literature has highlighted the multifaceted challenges and prospects associated with copper-based nanomaterials in the context of their translation from the laboratory to the clinic. In particular, biocompatibility remains a formidable hurdle, requiring innovative solutions to ensure the seamless integration into the human body. Additionally, achieving the controlled release of therapeutic agents from copper nanoparticles poses a complex challenge that requires meticulous engineering and precise design. Full article
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