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Novel Chemical and Biological Agents in the Treatment of Pain and Substance Use Disorders

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 2303

Special Issue Editors


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Guest Editor
Department of Pharmaceutical, Social and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, AL 35229, USA
Interests: pain; addiction; opioids; GPCRs; synthesis; self-administration; drug discrimination

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Guest Editor
Department Medicinal Chemistry, Translational Drug Development Core, Clinical and Translational Sciences Institute, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Interests: drug abuse and addiction; pain anxiety; medicinal chemistry; natural products; drug development

Special Issue Information

Dear Colleagues,

In the United States, drug overdose is one of the leading causes of death in adults aged 50 and under. In 2017, over 750,000 drug overdose deaths worldwide were attributed to drug abuse or substance use disorder. More than 70% of these deaths were due to opioids. Effective treatments for substance use disorder will help reduce these preventable deaths. In addition to the health impact of substance abuse on the individuals and their families, illicit drug use has a huge economic burden, estimated to cost about USD 193 billion in the United States alone. Thus, there is the need for novel molecules as treatments for substance use disorder. Moreover, there is a need for novel treatments for pain that do not have abuse liabilities. This Special Issue is dedicated to highlighting recent advancements in substance abuse and pain research. The scope includes, but is not limited to, the discovery and development of novel compounds to treat pain and substance use disorders, new therapeutic strategies for treating pain and substance use disorders, insights into mechanisms of pain and drug addiction, and the development of new behavioral models to treat substance use disorders. Original research articles, short communications, and review articles are welcomed.

Dr. Samuel Obeng
Prof. Dr. Christopher R. McCurdy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • addiction
  • substance use disorder
  • pain
  • opioids
  • cannabinoids
  • stimulants
  • depressants
  • hallucinogens

Published Papers (1 paper)

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Review

21 pages, 1406 KiB  
Review
Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors
by Melinda Hersey, Mattingly K. Bartole, Claire S. Jones, Amy Hauck Newman and Gianluigi Tanda
Molecules 2023, 28(13), 5270; https://doi.org/10.3390/molecules28135270 - 07 Jul 2023
Cited by 3 | Viewed by 1776
Abstract
Psychostimulant use disorders (PSUD) affect a growing number of men and women and exert sizable public health and economic burdens on our global society. Notably, there are some sex differences in the onset of dependence, relapse rates, and treatment success with PSUD observed [...] Read more.
Psychostimulant use disorders (PSUD) affect a growing number of men and women and exert sizable public health and economic burdens on our global society. Notably, there are some sex differences in the onset of dependence, relapse rates, and treatment success with PSUD observed in preclinical and clinical studies. The subtle sex differences observed in the behavioral aspects of PSUD may be associated with differences in the neurochemistry of the dopaminergic system between sexes. Preclinically, psychostimulants have been shown to increase synaptic dopamine (DA) levels and may downregulate the dopamine transporter (DAT). This effect is greatest in females during the high estradiol phase of the estrous cycle. Interestingly, women have been shown to be more likely to begin drug use at younger ages and report higher levels of desire to use cocaine than males. Even though there is currently no FDA-approved medication, modafinil, a DAT inhibitor approved for use in the treatment of narcolepsy and sleep disorders, has shown promise in the treatment of PSUD among specific populations of affected individuals. In this review, we highlight the therapeutic potential of modafinil and other atypical DAT inhibitors focusing on the lack of sex differences in the actions of these agents. Full article
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