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Organosulfur Compounds: Their Distribution and Biological Potential

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Prof. Dr. Ivica Blažević

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Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
Interests: natural products; glucosinolates; glycosidically bound volatiles; isothiocyanates; essential oils; biological activities; GC-MS; HPLC-MS/MS; NMR
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Dear Colleagues,

It has been estimated that nearly a quarter of all pharmaceutical products worldwide are derived from plant sources. Sulfur-containing plant metabolites occur in many plant families, such as Amaryllidaceae, Brassicaceae, Capparaceae, Caricaceae, Liliaceae, Moringaceae, Phytolaccaceae, Resedaceae, Rutaceae, and Solanaceae. They include a variety of chemical structures varying from primary metabolites, such as sulfur-containing amino acids, to secondary metabolites, such as glucosinolates and thiosulfonates. Associated with the typical enzymes in plants, they operate as bio-precursors to isothiocyanates, polysulfides, and other organosulfur volatiles which display a diversified and generally marked biological activity. The aim of the present Special Issue is to highlight and summarize the advances in research on sulfur-containing products; their distribution among plant families; isolation and identification methods; and their antioxidant, antimicrobial, cytotoxic, cholinesterase inhibition, and/or other biological properties. This Special Issue welcomes original studies and review articles on these aspects of various plant-based products to identify promising natural compounds beneficial for human health.

Prof. Dr. Ivica Blažević
Guest Editor

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10 pages, 1058 KiB

Open AccessArticle

Rocket (Eruca vesicaria (L.) Cav.) vs. Copper: The Dose Makes the Poison?

by Mario Nikola Mužek, Franko Burčul, Dario Omanović, Azra Đulović, Sandra Svilović and Ivica Blažević

Molecules 2022, 27(3), 711; https://doi.org/10.3390/molecules27030711 - 21 Jan 2022

Cited by 2 | Viewed by 2232

Abstract

The effects of copper addition, from various adsorbents, on the accumulation ability and glucosinolate content of cultivated rocket were studied. Different adsorbents (zeolite NaX, egg shells, substrate, fly ash) were treated with copper(II) solution with an adsorption efficiency of 98.36, 96.67, 51.82 and 39.13%, respectively. The lowest copper content and the highest total glucosinolate content (44.37 μg/g DW and 4269.31 µg/g DW, respectively) were detected in the rocket grown in the substrate with the addition of a substrate spiked with copper(II) ions. Rocket grown in the fly ash-substrate mixture showed an increase in copper content (84.98 μg/g DW) and the lowest total glucosinolate content (2545.71 µg/g DW). On the other hand, when using the egg shells-substrate mixture, the rocket copper content increased (113.34 μg/g DW) along with the total GSLs content (3780.03 µg/g DW), indicating the influence of an adsorbent type in addition to the copper uptake. The highest copper content of 498.56 μg/g DW was detected in the rocket watered with copper(II) solution with a notable decrease in the glucosinolate content, i.e., 2699.29 µg/g DW. According to these results rocket can be considered as a copper accumulator plant. Full article

(This article belongs to the Special Issue Organosulfur Compounds: Their Distribution and Biological Potential)

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11 pages, 771 KiB

Open AccessArticle

Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates

by Azra Đulović, Franko Burčul, Vedrana Čikeš Čulić, Mirko Ruščić, Petra Brzović, Sabine Montaut, Patrick Rollin and Ivica Blažević

Molecules 2021, 26(17), 5183; https://doi.org/10.3390/molecules26175183 - 27 Aug 2021

Cited by 4 | Viewed by 3089

Abstract

Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products-isothiocyanates (ITCs) using GC-MS analysis. Thirteen GSLs were identified with arylaliphatic as the major ones in the following order: 3-hydroxybenzyl GSL (glucolepigramin, 7), benzyl GSL (glucotropaeolin, 9), 3,4,5-trimethoxybenzyl GSL (11), 3-methoxybenzyl GSL (glucolimnanthin, 12), 4-hydroxy-3,5-dimethoxybenzyl GSL (3,5-dimethoxysinalbin, 8), 4-hydroxybenzyl GSL (glucosinalbin, 6), 3,4-dimethoxybenzyl GSL (10) and 2-phenylethyl GSL (gluconasturtiin, 13). GSL breakdown products obtained by hydrodistillation (HD) and CH₂Cl₂ extraction after hydrolysis by myrosinase for 24 h (EXT) as well as benzyl ITC were tested for their cytotoxic activity using MTT assay. Generally, EXT showed noticeable antiproliferative activity against human bladder cancer cell line UM-UC-3 and human glioblastoma cell line LN229, and can be considered as moderately active, while IC₅₀ of benzyl ITC was 12.3 μg/mL, which can be considered as highly active. Full article

(This article belongs to the Special Issue Organosulfur Compounds: Their Distribution and Biological Potential)

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