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Peptide Science: From Synthesis to Application II

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (1 November 2022) | Viewed by 1953

Special Issue Editors


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Guest Editor
Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992‐8510, Japan
Interests: total synthesis of peptidyl natural products; stereoselective synthesis of unusual amino acids; bioactive peptides; antimicrobials and antifungals
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina‐ku, Kyoto 607‐8412, Japan
Interests: medicinal chemistry; synthetic organic chemistry of unnatural amino acids; peptides; protein
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Peptides play a crucial role as biopolymers for pharmaceuticals, biomaterials, and advanced materials. A combination of a variety of amino acids results in characteristic properties for the corresponding peptides, creating new potential drug candidates and biomaterials. As the second part of this Special Issue in Molecules, the papers in this issue will present new findings on peptides and their chemistry, with approaches from a variety of research fields concerning synthetic chemistry, medicinal chemistry, and chemical biology.

Dr. Hiroyuki Konno
Dr. Kenichi Akaji
Guest Editors

Manuscript Submission Information

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Keywords

  • solid-phase peptide synthesis
  • native chemical ligation
  • peptidyl natural products
  • chemical biology of peptides and their target proteins
  • peptides in medicinal chemistry

Published Papers (1 paper)

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Research

26 pages, 10836 KiB  
Article
Study of Novel Peptides for Antimicrobial Protection in Solution and on Cotton Fabric
by Petar Todorov, Stela Georgieva, Desislava Staneva, Petia Peneva, Petar Grozdanov, Ivanka Nikolova, Evgenia Vasileva-Tonkova and Ivo Grabchev
Molecules 2022, 27(15), 4770; https://doi.org/10.3390/molecules27154770 - 26 Jul 2022
Cited by 3 | Viewed by 1670
Abstract
Some new N- and C-modified biomolecular peptide analogues of both VV-hemorphin-5 and VV-hemorphin-7 with varied amino acids (Cys, Glu, His), 1-adamantanecarboxylic acid, and niacin (nicotinic acid) were synthesized by solid-phase peptide synthesis—Fmoc (9-fluorenylmethoxy-carbonyl) chemistry and were characterized in water solutions with different pH [...] Read more.
Some new N- and C-modified biomolecular peptide analogues of both VV-hemorphin-5 and VV-hemorphin-7 with varied amino acids (Cys, Glu, His), 1-adamantanecarboxylic acid, and niacin (nicotinic acid) were synthesized by solid-phase peptide synthesis—Fmoc (9-fluorenylmethoxy-carbonyl) chemistry and were characterized in water solutions with different pH using spectroscopic and electrochemical techniques. Basic physicochemical properties related to the elucidation of the peptide structure at physiological pH have been also studied. The results showed that the interaction of peptide compounds with light and electricity preserves the structural and conformational integrity of the compounds in the solutions. Moreover, textile cotton fibers were modified with the new compounds and the binding of the peptides to the surface of the material was proved by FTIR and SEM analysis. Washing the material with an alkaline soap solution did not show a violation of the modified structure of the cotton. Antiviral activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5), the antimicrobial activity against B. cereus and P. aeruginosa used as model bacterial strains and cytotoxic effect of the peptide derivatives and modified cotton textile material has been evaluated. Antimicrobial tests showed promising activity of the newly synthesized compounds against the used Gram-positive and Gram-negative bacteria. The compounds C-V, H-V, AC-V, and AH-V were found slightly more active than NH7C and NCH7. The activity has been retained after the deposition of the compounds on cotton fibers. Full article
(This article belongs to the Special Issue Peptide Science: From Synthesis to Application II)
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