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Recent Advances in Cyclization Reactions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2384

Special Issue Editor


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Guest Editor
Department of Organic Chemistry and Technologies, Kuban State University, 350040 Krasnodar, Russia
Interests: active methylene compounds; nitriles; thioamides; selenoamides; S/Se heterocycles

Special Issue Information

Dear Colleagues,

Cyclization is undoubtedly one of the most powerful strategies for the synthesis of versatile functionalized molecules that are useful in organic synthesis, biomedicine, agriculture, optoelectronics, etc. According to Scopus, more than 18,000 documents having the terms “cyclization” or “heterocyclization” in the title, abstract or keywords were published in the last 5 years. This Special Issue intends to focus on new approaches to the construction of carbocycles or heterocycles using new reagents, reactions or unusual reaction conditions. However, papers dealing with new aspects of conformational behavior, reactivity, the biological activity of cyclization products and other relevant topics are also welcome. I invite everybody interested in this problem to contribute their materials to this Special Issue.

In addition to the above, upon request of the Organizing Committee I am pleased to inform you that the North Caucasus Organic Chemistry Symposium (NCOCS-2022) will be hosted by North Caucasus Federal University in Stavropol city, Russia from 18 to 22 April 2022 (https://hetchem.ru/). The symposium program includes the discussion of comprehensive problems in all fields of modern organic chemistry. Participants of the NCOCS-2022 symposium are encouraged to contribute full manuscripts covering any aspects of modern cyclization reactions to this Special Issue. In addition, participants of NCOCS-2022 will be granted a CHF 400 discount on the publishing fees.

Prof. Dr. Victor V. Dotsenko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic methods
  • reactivity
  • heterocyclic compounds
  • carbocyclic compounds
  • cascade reactions
  • cycloaddition
  • bioactive compounds
  • computational studies

Published Papers (1 paper)

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Review

24 pages, 5338 KiB  
Review
Recyclization of Maleimides by Binucleophiles as a General Approach for Building Hydrogenated Heterocyclic Systems
by Dmitriy Yu. Vandyshev and Khidmet S. Shikhaliev
Molecules 2022, 27(16), 5268; https://doi.org/10.3390/molecules27165268 - 18 Aug 2022
Cited by 4 | Viewed by 1687
Abstract
The building of heterocyclic systems containing hydrogenated fragments is an important step towards the creation of biologically-active compounds with a wide spectrum of pharmacological activity. Among the numerous methods for creating such systems, a special place is occupied by processes using N-substituted [...] Read more.
The building of heterocyclic systems containing hydrogenated fragments is an important step towards the creation of biologically-active compounds with a wide spectrum of pharmacological activity. Among the numerous methods for creating such systems, a special place is occupied by processes using N-substituted maleimides as the initial substrate. This molecule easily reacts in Diels-Alder/retro-Diels-Alder reactions, Michael additions with various nucleophiles, and co-polymerization processes, as have been described in numerous detailed reviews. However, information on the use of maleimides in cascade heterocyclization reactions is currently limited. This study is devoted to a review and analysis of existing literature data on the processes of recyclization of N-substituted maleimides with various C,N-/N,N-/S,N-di- and polynucleophilic agents, such as amidines, guanidines, diamines, aliphatic ketazines, aminouracils, amino- and mercaptoazoles, aminothiourea, and thiocarbomoyl pyrazolines, among others. The significant structural diversity of the recyclization products described in this study illustrates the powerful potential of maleimides as a building block in the organic synthesis of biologically-active compounds with hydrogenated heterocyclic fragments. Full article
(This article belongs to the Special Issue Recent Advances in Cyclization Reactions)
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