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Sea-Inspired Molecules

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 9037

Special Issue Editor


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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Montesano 149, 80131 Naples, Italy
Interests: sustainable exploitation and management of seas; marine natural products, isolation, and stereostructural elucidation of new lead compounds in antimicrobial and anticancer drug discovery; QQ and the QS system in bacteria symbiotic with sponges; cyanobacteria as source of novel lead compounds and toxins
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Special Issue Information

Dear Colleagues,

Oceans comprise 71% of the surface area of the earth. Keeping this data in mind, it is easy to understand why natural product chemists have looked to marine organisms as a novel source of new molecules since the early 80s. The marine environment is an excellent reservoir of novel bioactive molecules because they have chemical features not found in terrestrial organisms.

In this Special Issue, we will collect really creative and original works related to unusual skeletons, halogenated molecules, sulfur molecules, and nitrogen molecules in the form of original research articles and reviews, isolated from marine macro- and microorganisms, as well as original methodologies used to assign absolute stereochemistry.

Because it is largely recognized that scientific works by women are often overlooked [1] despite the importance of authorship in determining careers, we would especially appreciate original contributions with the lead and/or corresponding author being a woman.


Prof. Dr. Valeria Costantino
Guest Editor

1. www.sciencedaily.com/releases/2019/02/190207102624.htm

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Keywords

  • marine organisms
  • molecules
  • halogenated compounds
  • sulfur compounds
  • nitrogen compounds
  • new inspiring skeletons

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Published Papers (2 papers)

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Research

17 pages, 789 KiB  
Article
New Chlorinated 2,5-Diketopiperazines from Marine-Derived Bacteria Isolated from Sediments of the Eastern Mediterranean Sea
by Maria Harizani, Eleni Katsini, Panagiota Georgantea, Vassilios Roussis and Efstathia Ioannou
Molecules 2020, 25(7), 1509; https://doi.org/10.3390/molecules25071509 - 26 Mar 2020
Cited by 23 | Viewed by 3615
Abstract
From the organic extracts of five bacterial strains isolated from marine sediments collected in the East Mediterranean Sea, three new (15, 16, 31) and twenty-nine previously reported (114, 1730, 32) metabolites [...] Read more.
From the organic extracts of five bacterial strains isolated from marine sediments collected in the East Mediterranean Sea, three new (15, 16, 31) and twenty-nine previously reported (114, 1730, 32) metabolites bearing the 2,5-diketopiperazine skeleton were isolated. The structures of the chlorinated compounds 15, 16, and 31 were elucidated by extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 15 and 16 were evaluated for their antifungal activity against Candida albicans and Aspergillus niger but were proven inactive. The relevant literature is supplemented with complete NMR assignments and revisions for the 29 previously reported compounds. Full article
(This article belongs to the Special Issue Sea-Inspired Molecules)
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12 pages, 2509 KiB  
Article
Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach
by Elisa Bonandi, Giada Tedesco, Dario Perdicchia and Daniele Passarella
Molecules 2020, 25(5), 1057; https://doi.org/10.3390/molecules25051057 - 27 Feb 2020
Cited by 5 | Viewed by 4411
Abstract
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, [...] Read more.
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, employing commercially available 2-piperidine ethanol as a versatile precursor. Here, we report the exploration of another ramification of our DOS approach, that led us to the stereoselective total synthesis of (–)-anaferine, a bis-piperidine alkaloid present in Withania somnifera extract. This natural product was obtained in 9% overall yield over 13 steps, starting from a key homoallylic alcohol previously synthesised in our laboratory. Therefore, the collection of piperidine-derivatives accessible from 2-piperidine ethanol was enriched with a new, diverse scaffold. Full article
(This article belongs to the Special Issue Sea-Inspired Molecules)
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