The Study of the Effects of Nanoparticles on Human Cells

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 1150

Special Issue Editors


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Department of Medicine, Surgery and Pharmacy, University of Sassari, Via Muroni 23/a, 07100 Sassari, Italy
Interests: drug delivery; nanomedicine; nanoparticles
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Guest Editor
Department of Medicine, Surgery and Pharmacy, University of Sassari, Via Muroni 23/a, 07100 Sassari, Italy
Interests: polymeric nanoparticles; nanomedicine; pharmaceutical technology; lipid nanoparticles; nanoprecipitation; nanoparticles loading poorly soluble drugs; drug delivery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Chemical, Physical, Mathematical and Natural Science, University of Sassari, 07100 Sassari, Italy
Interests: drug delivery; lipid nanoparticles; polymer nanoparticles; liposome; 3D-printing; microneedles; transdermal delivery; dermal delivery; melanoma; dermatology; skin diseases; cancer drug delivery

Special Issue Information

Dear Colleagues,

Nanotechnology is a branch of science concerned with the design, fabrication, and application of nanoparticles (NPs) and nanomaterials. Introduced by Feynman in 1959, the fields of nanoscience and nanotechnology have been subjected to growing interest from scientists in almost all research areas. They have not only been integrated into chemistry, engineering, agriculture, biology, and materials science, but have also been used to produce nanostructured medical devices and nanotherapeutics. As a result of this interest, NPs began to be commercialised in the early 2000s and exposed to popular opinion, facing both praise and criticism from the public. Indeed, despite the extent of documented research, there is still a gap in knowledge regarding the risk to human health consequent to exposure to NPs.

In this Special Issue of Nanomaterials, we welcome original research articles and reviews regarding nanoparticle applications and their effects on human cells. Particularly, articles should focus on the harmful effects of (a) inorganic-based NPs, (b) carbon-based NPs, (c) organic NPs, including lipid, polymer, and hybrids, (d) nanomaterials, and (e) engineered NPs on human cells. Further potential research areas include (but are not limited to) the following:

  • drug delivery;
  • medical therapies and diagnosis;
  • biology and biotechnologies;
  • agriculture and food industry;
  • industrial processes;
  • renewable energies;
  • engineering and bio-engineering.

All contributions related to underlying cell viability and cytotoxicity, mechanisms of toxicology, and related evaluation models for analyzing NP risk effects are welcome.

We look forward to receiving your contributions.

Prof. Dr. Paolo Giunchedi
Dr. Carla Serri
Guest Editors

Dr. Sara Demartis
Guest Editor Assistant

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Keywords

  • nanoparticles
  • nanomaterials
  • nanotoxicology
  • cytotoxicity
  • immunotoxicity
  • genotoxicity
  • carcinogenesis
  • oxidative stress
  • inflammation

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Published Papers (1 paper)

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Research

14 pages, 7359 KiB  
Article
Chlorin e6-Conjugated Mesoporous Titania Nanorods as Potential Nanoplatform for Photo-Chemotherapy
by Estefanía Vélez-Peña, Verónica A. Jiménez, Joaquín Manzo-Merino, Joel B. Alderete and Cristian H. Campos
Nanomaterials 2024, 14(11), 933; https://doi.org/10.3390/nano14110933 - 25 May 2024
Viewed by 834
Abstract
Photodynamic therapy (PDT) has developed as an efficient strategy for cancer treatment. PDT involves the production of reactive oxygen species (ROS) by light irradiation after activating a photosensitizer (PS) in the presence of O2. PS-coupled nanomaterials offer additional advantages, as they [...] Read more.
Photodynamic therapy (PDT) has developed as an efficient strategy for cancer treatment. PDT involves the production of reactive oxygen species (ROS) by light irradiation after activating a photosensitizer (PS) in the presence of O2. PS-coupled nanomaterials offer additional advantages, as they can merge the effects of PDT with conventional enabling-combined photo-chemotherapeutics effects. In this work, mesoporous titania nanorods were surface-immobilized with Chlorin e6 (Ce6) conjugated through 3-(aminopropyl)-trimethoxysilane as a coupling agent. The mesoporous nanorods act as nano vehicles for doxorubicin delivery, and the Ce6 provides a visible light-responsive production of ROS to induce PDT. The nanomaterials were characterized by XRD, DRS, FTIR, TGA, N2 adsorption–desorption isotherms at 77 K, and TEM. The obtained materials were tested for their singlet oxygen and hydroxyl radical generation capacity using fluorescence assays. In vitro cell viability experiments with HeLa cells showed that the prepared materials are not cytotoxic in the dark, and that they exhibit photodynamic activity when irradiated with LED light (150 W m−2). Drug-loading experiments with doxorubicin (DOX) as a model chemotherapeutic drug showed that the nanostructures efficiently encapsulated DOX. The DOX-nanomaterial formulations show chemo-cytotoxic effects on Hela cells. Combined photo-chemotoxicity experiments show enhanced effects on HeLa cell viability, indicating that the conjugated nanorods are promising for use in combined therapy driven by LED light irradiation. Full article
(This article belongs to the Special Issue The Study of the Effects of Nanoparticles on Human Cells)
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