Applications of Noble Metal Nanoparticles in Biosensing and Bioimaging

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 1082

Special Issue Editor


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Guest Editor
Department of Physics and Astronomy, The University of Georgia, Athens, GA 30602, USA
Interests: nanostructure/thin film fabrication and characterization; metamaterials and plasmonic nanostructures; chemical and biological sensors; nano-photocatalysts; antimicrobial materials; nanomotors and their applications
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Special Issue Information

Dear Colleagues,

In the last few decades, noble metal nanoparticles (NMNs), particularly gold and silver, have been widely utilized in the development of novel chemical/biological sensors and bioimaging applications due to their unique physical and chemical properties. With an improved understanding of these particles and their alloy forms, advances in fabrication and synthesis, and the integration of AI technology, new developments in this field are readily anticipated. This Special Issue of Nanomaterials focuses on the following aspects of NMNs in biosensing and bioimaging:

  • The fabrication and synthesis of new NMNs, hybrid particles, and metal alloys and an understanding of their properties;
  • A deeper understanding of how NMN particles and variations interact with targeted chemicals or biomolecules and the resulting signal changes;
  • Key issues in sensing or imaging measurements, such as data pre-treatment, reproducibility, repeatability, and replicability, particularly in detection or imaging from complex media with potentially high background signals;
  • The integration of artificial intelligence in sensor design, data analysis, and interpretation;
  • The development of point-of-care devices and new applications in sensing and bioimaging.

We warmly welcome original articles and review submissions.

Prof. Dr. Yiping Zhao
Guest Editor

Manuscript Submission Information

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Keywords

  • nanomaterials
  • machine learning/deep learning
  • noble metal nanoparticles
  • biomolecules
  • biosensing
  • bioimaging

Published Papers (1 paper)

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Research

34 pages, 7127 KiB  
Article
On the Measurements of the Surface-Enhanced Raman Scattering Spectrum: Effective Enhancement Factor, Optical Configuration, Spectral Distortion, and Baseline Variation
by Yiping Zhao
Nanomaterials 2023, 13(23), 2998; https://doi.org/10.3390/nano13232998 - 22 Nov 2023
Cited by 1 | Viewed by 831
Abstract
In this paper, a comprehensive theoretical framework for understanding surface-enhanced Raman scattering (SERS) measurements in both solution and thin-film setups, focusing on electromagnetic enhancement principles, was presented. Two prevalent types of SERS substrates found in the literature were investigated: plasmonic colloidal particles, including [...] Read more.
In this paper, a comprehensive theoretical framework for understanding surface-enhanced Raman scattering (SERS) measurements in both solution and thin-film setups, focusing on electromagnetic enhancement principles, was presented. Two prevalent types of SERS substrates found in the literature were investigated: plasmonic colloidal particles, including spherical and spheroid nanoparticles, nanoparticle diameters, and thin-film-based SERS substrates, like ultra-thin substrates, bundled nanorods, plasmonic thin films, and porous thin films. The investigation explored the impact of analyte adsorption, orientation, and the polarization of the excitation laser on effective SERS enhancement factors. Notably, it considered the impact of analyte size on the SERS spectrum by examining scenarios where the analyte was significantly smaller or larger than the hot spot dimensions. The analysis also incorporated optical attenuations arising from the optical properties of the analyte and the SERS substrates. The findings provide possible explanations for many observations made in SERS measurements, such as variations in relative peak intensities during SERS assessments, reductions in SERS intensity at high analyte concentrations, and the occurrence of significant baseline fluctuations. This study offers valuable guidance for optimizing SERS substrate design, enhancing SERS measurements, and improving the quantification of SERS detection. Full article
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