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Nanomaterials
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Advances in Toxicity of Nanoparticles in Organisms (2nd Edition)
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Advances in Toxicity of Nanoparticles in Organisms (2nd Edition)

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 1550

Special Issue Editor

Dr. Ioana Bâldea

E-Mail Website
Guest Editor
Department of Physiology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 1–3 Clinicilor Street, 400006 Cluj-Napoca, Romania
Interests: in vitro cell cultures; citotoxicity; natural and synthetic compounds; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of a previously successful Special Issue, entitled, “Advances in Toxicity of Nanoparticles in Organisms” and is hosted by the same Guest Editor.

The present Issue welcomes authors and potential contributors to submit original articles or review papers dedicated to recent fundamental and applicative research into the biocompatibility testing of nanomaterials. We are particularly interested in efforts to investigate the impact of nanoparticles on different biological experimental settings in vitro and in vivo, including toxicity aspects; the possibility of the modulation of toxicity through “green synthesis”; or the design of complex nanoplatforms suitable for biomedical applications.

This Special Issue will cover topics that include, but are not limited to: development of biologically active nanostructured compounds from natural or synthetic sources, green synthesis, metallic nanoparticles, nano-alloys, graphene, nanotubes, composite nanomaterials, cytotoxicity, systemic toxicity, the role of nanoparticles in biological processes, nanoplatforms in theranostic approaches, and applications of nanomaterials in medicine. 

Dr. Ioana Bâldea
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • systemic toxicity
  • cytotoxicity
  • biomedical application of nanomaterials
  • theranostics

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Related Special Issue

Published Papers (2 papers)

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Research

22 pages, 9684 KiB  
Article
Techniques and Instruments for Assessing and Reducing Risk of Exposure to Nanomaterials in Construction, Focusing on Fire-Resistant Insulation Panels Containing Nanoclay
by Romeo Cristian Ciobanu and Mihaela Aradoaei
Nanomaterials 2024, 14(18), 1470; https://doi.org/10.3390/nano14181470 - 10 Sep 2024
Viewed by 292
Abstract
The paper explains how nano exposure is assessed in the construction field and focuses on the production of fire-resistant insulation panels with nanoclay. Utilizing the commercial ANSYS CFX® software, a preliminary theoretical simulation was conducted on nano exposure in the workplace, which [...] Read more.
The paper explains how nano exposure is assessed in the construction field and focuses on the production of fire-resistant insulation panels with nanoclay. Utilizing the commercial ANSYS CFX® software, a preliminary theoretical simulation was conducted on nano exposure in the workplace, which revealed that particle dispersion is primarily driven by diffusion. Panel post-processing through drilling results in the highest inhalation exposure, followed by mixing and grinding activities. Compared to a state of ‘no activity’, each activity resulted in an exposure increase by a factor of min. 1000. An overall assessment suggests that the use of nanoparticles in construction materials may not significantly heighten workers’ exposure to nanopowders when considering particle concentration alone as opposed to using traditional micro-scale materials. However, the issue persists when it comes to blending powders or performing finishing tasks on panels, with concentration levels being significantly higher for drilling, grinding, and mixing powders at 2.4 times above the standard reference value (40,000 particles/cm3); this is unacceptable, even for brief durations. Examination of dermal contact with gloves and masks worn by workers revealed no nanoparticle penetration. Safety measures were proposed for workers based on decision trees to enhance their safety. Ten categories of protection strategies have been devised to combat the impact of nanoparticles, which are tailored to specific technical situations, but they must be modified for various types of nanoparticles despite potential shared health implications. Full article
(This article belongs to the Special Issue Advances in Toxicity of Nanoparticles in Organisms (2nd Edition))
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23 pages, 1405 KiB  
Article
Multi-Endpoint Toxicological Assessment of Chrysin Loaded Oil-in-Water Emulsion System in Different Biological Models
by Pornsiri Pitchakarn, Pisamai Ting, Pensiri Buacheen, Jirarat Karinchai, Woorawee Inthachat, Boonrat Chantong, Uthaiwan Suttisansanee, Onanong Nuchuchua and Piya Temviriyanukul
Nanomaterials 2024, 14(12), 1001; https://doi.org/10.3390/nano14121001 - 8 Jun 2024
Cited by 1 | Viewed by 928
Abstract
Chrysin is hypothesized to possess the ability to prevent different illnesses, such as diabetes, cancer, and neurodegenerative disorders. Nonetheless, chrysin has a low solubility under physiological conditions, resulting in limited bioavailability. In a previous study, we utilized an oil-in-water emulsion system (chrysin-ES or [...] Read more.
Chrysin is hypothesized to possess the ability to prevent different illnesses, such as diabetes, cancer, and neurodegenerative disorders. Nonetheless, chrysin has a low solubility under physiological conditions, resulting in limited bioavailability. In a previous study, we utilized an oil-in-water emulsion system (chrysin-ES or chrysin-NE) to encapsulate chrysin, thereby increasing its bioaccessibility and preserving its antioxidant and anti-Alzheimer’s properties. To promote the chrysin-ES as a supplementary and functional food, it was obligatory to carry out a safety assessment. Cytotoxicity testing showed that chrysin-ES was harmless, with no killing effect on 3T3-L1 (adipocytes), RAW 264.7 (macrophages), HEK293 (kidney cells), and LX-2 (hepatic stellate cells). The acute toxicity evaluation demonstrated that the 50% lethal dose (LD50) for chrysin-ES was greater than 2000 mg/kg BW. Genotoxicity assessments found that chrysin-ES did not induce DNA mutations in vitro or in vivo. Furthermore, chrysin and chrysin-ES exhibited anti-mutagenic properties against PhIP-induced and IQ-induced mutagenesis in the Ames test, while they inhibited urethane-, ethyl methanesulfonate-, mitomycin C-, and N-nitrosomethylurea-mediated mutations in Drosophila. The present study illustrates the safety and anti-genotoxicity properties of chrysin-ES, allowing for the further development of chrysin-based food supplements and nutraceuticals. Full article
(This article belongs to the Special Issue Advances in Toxicity of Nanoparticles in Organisms (2nd Edition))
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