Research on Antibacterial Properties of Metal-Based Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 531

Special Issue Editor


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Biomedical Nanoengineering Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, Australia
Interests: Their research explores the use of nanomaterials in medicine, including advanced drug delivery systems, regenerative medicine, and nanoengineered biomaterials. They focus on developing antimicrobial surfaces and nanoparticles to address antibiotic resistance and on creating smart implants and devices by integrating nanomaterials with biomaterials to enhance medical treatments and patient outcomes
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Special Issue Information

Dear Colleagues,

Research into the antibacterial properties of metal-based nanomaterials represents a multifaceted exploration into harnessing the potential of nanotechnology to combat microbial infections. These investigations delve into a diverse array of metal nanoparticles, with prominent examples including silver, copper, zinc oxide, and titanium dioxide nanoparticles, each exhibiting unique characteristics and mechanisms of action against bacteria. The high surface-area-to-volume ratio and distinct physicochemical properties of these nanomaterials contribute to their remarkable antimicrobial efficacy.

Central to this research endeavor is the comprehensive understanding of the intricate mechanisms that underly the antibacterial action of metal-based nanomaterials. These mechanisms may include the disruption of bacterial cell membranes, the generation of reactive oxygen species, or the interference with essential cellular processes. Moreover, scientists explore various synthesis methodologies and surface modifications to tailor the properties of these nanomaterials, aiming to optimize their antibacterial effectiveness while ensuring biocompatibility and safety.

The implications of this research extend far beyond the laboratory, with potential applications spanning diverse sectors, including healthcare, environmental remediation, and consumer products. In the medical realm, metal-based nanomaterials hold promise for the development of advanced antimicrobial coatings for medical devices, novel wound dressings with enhanced healing properties, and textiles resistant to bacterial colonization. Furthermore, these nanomaterials offer innovative solutions for environmental disinfection, water purification, and food safety. Against the backdrop of mounting concerns over antibiotic resistance, the exploration of metal-based nanomaterials as alternative antibacterial agents represents a crucial step forward in addressing the global challenge of microbial infections.

Our Special Issue is dedicated to the exploration of 'Research on Antibacterial Properties of Metal-Based Nanomaterials.' This Special Issue will encompass comprehensive research concerning the application of metal-based nanomaterials for antibacterial purposes. The primary goal is to highlight the potential strategies that can be achieved solely through the collaborative efforts of various research disciplines. This endeavor seeks to stimulate increased cross-disciplinary partnerships, fostering the acceleration of research and development in antimicrobial technologies. The wide-ranging advantages of these endeavors encompass all facets of society.

Subject matters cover a range of topics, which may encompass the following:

  • Synthesis of innovative antimicrobial metal-based nanoparticles and various nanomaterials;
  • Development of intelligent and reactive materials and coatings that are designed to release antimicrobial agents solely when triggered by the presence of bacteria;
  • Delving into the fundamental mechanisms that underly antimicrobial resistance;
  • Exploration of metallic nanoparticles, materials, and coatings proficient in combating mature and well-established biofilms.

Dr. Richard Bright
Guest Editor

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Keywords

  • antibacterial
  • bactericidal
  • antibiotic resistance
  • biofilm
  • antifouling
  • metal nanomaterials
  • metal-based nanoparticles
  • nanotechnology
  • nanomaterials

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Published Papers (1 paper)

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Research

17 pages, 20722 KiB  
Article
AFM for Nanomechanical Assessment of Polymer Overcoatings on Nanoparticle-Decorated Biomaterials
by Jonathan Wood, Dennis Palms, Ruvini Dabare, Krasimir Vasilev and Richard Bright
Nanomaterials 2024, 14(18), 1475; https://doi.org/10.3390/nano14181475 - 11 Sep 2024
Viewed by 180
Abstract
Nanoparticle adhesion to polymer and similar substrates may be prone to low nano-Newton forces, disrupting the surface bonds and patterning, potentially reducing the functionality of complex surface patterns. Testing this, a functionalised surface reported for biological and medical applications, consisting of a thin [...] Read more.
Nanoparticle adhesion to polymer and similar substrates may be prone to low nano-Newton forces, disrupting the surface bonds and patterning, potentially reducing the functionality of complex surface patterns. Testing this, a functionalised surface reported for biological and medical applications, consisting of a thin plasma-derived oxazoline-based film with 68 nm diameter covalently bound colloidal gold nanoparticles attached within an aqueous solution, underwent nanomechanical analysis. Atomic Force Microscopy nanomechanical analysis was used to quantify the limits of various adaptations to these nanoparticle-featured substrates. Regular and laterally applied forces in the nano-Newton range were shown to de-adhere surface-bound gold nanoparticles. Applying a nanometre-thick overcoating anchored the nanoparticles to the surface and protected the underlying base substrate in a one-step process to improve the overall stability of the functionalised substrate against lower-range forces. The thickness of the oxazoline-based overcoating displayed protection from forces at different rates. Testing overcoating thickness ranging from 5 to 20 nm in 5 nm increments revealed a significant improvement in stability using a 20 nm-thick overcoating. This approach underscores the importance of optimising overcoating thickness to enhance nanoparticle-based surface modifications’ durability and functional integrity. Full article
(This article belongs to the Special Issue Research on Antibacterial Properties of Metal-Based Nanomaterials)
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