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Nanomaterials
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Current and Future Perspectives in Nanomaterials for Drug Delivery and...
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Current and Future Perspectives in Nanomaterials for Drug Delivery and Controlled Release

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1669

Special Issue Editors

Dr. Oana Cadar

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Guest Editor
INCDO-INOE 2000, Research Institute for Analytical Instrumentation, 400293 Cluj-Napoca, Romania
Interests: porous materials; nanomaterials; synthesis; X-ray diffraction; applications
Special Issues, Collections and Topics in MDPI journals
Dr. Erika Andrea Levei

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Guest Editor
INCDO-INOE 2000, Research Institute for Analytical Instrumentation, 400293 Cluj-Napoca, Romania
Interests: analytical chemistry; nanocomposites; infrared spectroscopy; sol–gel synthesis; spinel ferrite
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The use of nanomaterials as delivery systems for drugs and bioactive compounds provides important advantages, such as high stability, high loading capacity, the possibility to incorporate a wide range of hydrophilic and hydrophobic drugs, and suitability for all routes of administration. Loading conventional drugs and bioactive compounds onto nanomaterials enhances their bioavailability, therapeutic effects, solubility, stability, safety, and tolerability and minimizes organ toxicity and non-selective delivery to unwanted sites. Further, these formulations may provide a selective, controlled, and sustained release to target tissues and favor specific absorption and distribution. As guest editors, we encourage potential contributors to submit full papers, communications, or reviews on all aspects related to nanomaterials used in targeted delivery and in controlled release of drugs and bioactive compounds. This Special Issue will gather information on the current state of the art and future perspectives concerning the design of nanomaterials for targeted delivery, selection of the material substrate for nanoparticles, methodology used to load the drugs into nanoparticles, as well as studies of the solubility, stability, pharmacokinetics, and tissue distribution of carried drugs and bioactive compounds.

Dr. Oana Cadar
Dr. Erika Andrea Levei
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • drug
  • bioactive compounds
  • delivery
  • controlled release

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Published Papers (1 paper)

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Research

22 pages, 5613 KiB  
Article
Preparation and Characterization of Spray-Dried Hybrid Nanocrystal–Amorphous Solid Dispersions (HyNASDs) for Supersaturation Enhancement of a Slowly Crystallizing Drug
by Mahbubur Rahman, Keanu Radgman, James Tarabokija, Stephanie Ahmad and Ecevit Bilgili
Nanomaterials 2023, 13(17), 2419; https://doi.org/10.3390/nano13172419 - 25 Aug 2023
Cited by 1 | Viewed by 1325
Abstract
We prepared hybrid nanocrystal–amorphous solid dispersions (HyNASDs) to examine their supersaturation capability in the release of a poorly soluble drug, itraconazole (ITZ), a slow crystallizer during dissolution. The HyNASD formulations included a polymer (HPC: hydroxypropyl cellulose, Sol: Soluplus, or VA64: Kollidon-VA64) and a [...] Read more.
We prepared hybrid nanocrystal–amorphous solid dispersions (HyNASDs) to examine their supersaturation capability in the release of a poorly soluble drug, itraconazole (ITZ), a slow crystallizer during dissolution. The HyNASD formulations included a polymer (HPC: hydroxypropyl cellulose, Sol: Soluplus, or VA64: Kollidon-VA64) and a surfactant (SDS: sodium dodecyl sulfate). Additionally, the dissolution performance of the HyNASDs and ASDs was compared. To this end, wet-milled aqueous nanosuspensions containing a 1:5 ITZ:polymer mass ratio with/without SDS as well as solutions of the same ratio without SDS in dichloromethane were spray-dried. XRPD–DSC confirmed that ASDs were formed upon spray drying the solution-based feeds, whereas HyNASDs (~5–30% amorphous) were formed with the nanosuspension-based feeds. SDS aided to stabilize the ITZ nanosuspensions and increase the amorphous content in the spray-dried powders. During dissolution, up to 850% and 790% relative supersaturation values were attained by HyNASDs with and without SDS, respectively. Due to the stronger molecular interaction between ITZ–Sol than ITZ–HPC/VA64 and micellar solubilization by Sol, Sol-based HyNASDs outperformed HPC/VA64-based HyNASDs. While the ASD formulations generated greater supersaturation values (≤1670%) than HyNASDs (≤790%), this extent of supersaturation from a largely nanocrystalline formulation (HyNASD) has not been achieved before. Overall, HyNASDs could boost drug release from nanoparticle-based formulations and may render them competitive to ASDs. Full article
(This article belongs to the Special Issue Current and Future Perspectives in Nanomaterials for Drug Delivery and Controlled Release)
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