Two Dimensional Materials for Biomedical Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 10 December 2024 | Viewed by 856

Special Issue Editor


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Guest Editor
Department of Science and Engineering of Materials, Environment and Urban Planning, Polytechnic University of Marche, 60121 Ancona, Italy
Interests: ab initio simulations on 2D and 3D solid, organic, and inorganic systems; semi-empirical atomistic simulations on multi-component devices; simulations of molecular dynamics on synthetic and natural systems, both ordered and amorphous; use of electron paramagnetic resonance for the study of free radicals and antioxidant effects
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Special Issue Information

Dear Colleagues,

Ever since a layer of graphene has been isolated from graphite, there has been an ever-increasing interest in layered materials, thanks to the prominent electrical, optical, and mechanical properties that have been detected, leading to the idea that new two-dimensional nanomaterials could be obtained, starting from different bulk systems. To date, many 2D materials are widely used, and have found applications in different fields, including energy, electronic, coating, optoelectronic, and biomedical. Indeed, many two-dimensional materials are currently being used for tissue engineering, drug delivery, cell labeling, and biosensors. Since the prominent capabilities of these systems in biomedical fields are indisputable, strong efforts are required to avoid toxicity and to increase their efficacy in the biomedical environment.

The purpose of this Special Issue is to highlight the latest advances in the use of 2D materials in all biomedical and related fields, such as targeted cancer therapies, drug delivery, biosensors, antibacterial, antiviral therapies, photothermal, and catalysis. Proposals relating to tissue engineering and to the applications for motor support are also welcomed. Furthermore, topics that do not include administration and contacts with biological systems are also included.

All 2D systems are considered, from graphene-based systems to black phosphorus, nanosheets, MXenes, MBenes, LDH, MOFs, and COFs, in single- or several-monolayer statuses. This Special issue focuses on the cutting-edge research of two-dimensional biomaterials, and therefore aims to accelerate the translation of 2D technology, bringing promising results in clinical research and promoting human healthcare.

Experimental and theoretical contents are both welcomed, presented in the form of articles, reviews, or communications.

Dr. Emiliano Laudadio
Guest Editor

Manuscript Submission Information

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Keywords

  • 2D material
  • biomedical
  • biocompatible
  • monolayer

Published Papers (1 paper)

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Research

17 pages, 3446 KiB  
Article
MXene/Carbon Dots Nanozyme Composites for Glutathione Detection and Tumor Therapy
by Xiaofei Lu, Jingjing Jia, Zonghua Wang and Wenjing Wang
Nanomaterials 2024, 14(13), 1090; https://doi.org/10.3390/nano14131090 - 25 Jun 2024
Viewed by 696
Abstract
Co-N-CDs-based MXene nanocomposites (MXene@PDA/Co-N-CDs) were constructed by decorating Co-N-CDs on polydopamine-functionalized MXene nanosheets. Both Co-N-CDs and MXene nanosheets have peroxidase-like activity; when the two materials are combined to form MXene@PDA/Co-N-CDs nanocomposites, the peroxide-like activity can be further enhanced. MXene@PDA/Co-N-CDs could oxidize the substrate [...] Read more.
Co-N-CDs-based MXene nanocomposites (MXene@PDA/Co-N-CDs) were constructed by decorating Co-N-CDs on polydopamine-functionalized MXene nanosheets. Both Co-N-CDs and MXene nanosheets have peroxidase-like activity; when the two materials are combined to form MXene@PDA/Co-N-CDs nanocomposites, the peroxide-like activity can be further enhanced. MXene@PDA/Co-N-CDs could oxidize the substrate 3,3′5,5′-tetramethylbenziline (TMB) to form ox-TMB, as confirmed by detecting the absorption of the blue products. A highly selective colorimetric biosensor was developed for the determination of glutathione (GSH) in the concentration range of 0.3 to 20 µM with a lower detection limit (LOD) of 0.12 µM, which realized the accurate detection of GSH in human serum and urine samples. Moreover, in the tumor microenvironment, MXene@PDA/Co-N-CDs could catalyze hydrogen peroxide to produce hydroxyl free radicals and produce a photothermal effect under the exposure of NIR-I irradiation. The catalytic activity of MXene@PDA/Co-N-CD nanocomposites was fully achieved for the death of cancer cells through photothermal/photodynamic synergistic therapy. The MXene@PDA/Co-N-CDs nanozyme offers multiple applications in GSH detection and tumor therapy. Full article
(This article belongs to the Special Issue Two Dimensional Materials for Biomedical Applications)
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