Biomedical Applications of Nano-Chitosan
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: closed (20 January 2021) | Viewed by 6876
Special Issue Editor
Interests: nanocomposite; food packaging; antimicrobial; cancer biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chitosan-based nanomaterials have attracted significant attention in the biomedical field because of their unique biodegradable, biocompatible, non-toxic, and antimicrobial nature. It can be applied in many fields, especially in medicine. As a delivery carrier, it has great potential and cannot be compared with other polymers. Chitosan is extremely difficult to solubilize in water, but it can be solubilized in acidic solution. In therapeutics, chitosan and chitosan-based materials are used as antimicrobial, antitumor, antiulcer, antidiabetic, and cholesterol-lowering agents. The conformational flexibility of chitosan is attributed to the presence of the free primary amino groups, which makes chitosan an ideal candidate for biofabrication. Various methods, such as ionic gelation, desolvation, spray drying, and covalent cross-linking, have been employed for the functionalization of chitosan. Nanoparticles and their biofabrication impart desirable functional characteristics to chitosan. The molecular weight and the concentration of chitosan used, along with the amount of cross-linking, govern the physical properties of the chitosan nanoparticles formed. Chitosan nanocomposites have been shown to improve the dissolution rate of poorly soluble drugs, and are thus exploited for the enhancement of drug bioavailability and delivery. Various therapeutic agents, such as anticancer, anti-inflammatory, antibiotic, antithrombotic, steroid, protein, amino acid, antidiabetic, and diuretic compounds, have been incorporated in chitosan nanocomposites. The controlled release of therapeutic agents opens new windows in drug delivery and bio-imaging techniques using chitosan. Hence, chitosan and its nano-derivatives serve as one of the sustainable and ecofriendly alternatives to synthetic polymers in biomedical applications.
Dr. Shiv Shankar
Guest Editor
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Keywords
- chitosan
- nanoparticle
- nanocomposite
- biomedical application
- antimicrobial
- anticancer
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