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Nanomaterials
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Fluorescent Nanomaterials for Sensing, Bioimaging, and Therapy
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Fluorescent Nanomaterials for Sensing, Bioimaging, and Therapy

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2654

Special Issue Editor

Dr. Xuanjun Zhang

E-Mail Website
Guest Editor
Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
Interests: molecular probes; nanosensors; bioimaging

Special Issue Information

Dear Colleagues,

Fluorescent probes are indispensable chemical tools for use in high-quality biomedical research and clinical diagnosis. To study complicated biological processes such as autophagy, drug resistance, programmed and non-programmed cell death, etc., it is important to accurately measure the concentration fluctuations of some relevant ion/molecules. Compared with small-molecule dyes, nanoprobes have many advantages for use in biomedical applications such as longer circulation time, brighter fluorescence, multifunctionality, etc. Fluorescent nanosensors have also been widely used in the monitoring of environmental pollutions and harmful food additives due to their high sensitivity and low cost. Therefore, the development of effective nanoprobes as chemical tools is not only beneficial to basic research, but also to environmental protection and our daily life.

This Special Issue will attempt to cover fluorescent nanomaterials including (but not limited to) MOF, polymer dots, and dye-doped silica nanoparticles. Articles concerning not only preparation methods and property studies, but in particular, the study of their structure–function correlation and applications in sensing, bioimaging, and photodynamic therapy are welcome. And the format of welcomed articles includes full papers, communications, and reviews. 

Dr. Xuanjun Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent nanoprobes
  • ratiometric sensing
  • environmental pollutions
  • food additives
  • tumor microenvironment
  • photodynamic therapy
  • nanoparticle surface functionalization

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Published Papers (2 papers)

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12 pages, 2583 KiB  
Article
A Novel Electrochemical Sensing Strategy Based on Poly (3, 4-ethylenedioxythiophene): Polystyrene Sulfonate, AuNPs, and Ag+ for Highly Sensitive Detection of Alkaline Phosphatase
by Jiangshan Lei, Jian Kang, Jifa Liu and Guannan Wang
Nanomaterials 2022, 12(19), 3392; https://doi.org/10.3390/nano12193392 - 28 Sep 2022
Cited by 5 | Viewed by 1661
Abstract
Alkaline phosphatase (ALP) is a crucial marker for the clinical analysis and detection of many diseases. In this study, an accurate signal amplification strategy was proposed for the sensing and quantification of alkaline phosphatase using poly (3, 4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), gold nanoparticles (AuNPs), [...] Read more.
Alkaline phosphatase (ALP) is a crucial marker for the clinical analysis and detection of many diseases. In this study, an accurate signal amplification strategy was proposed for the sensing and quantification of alkaline phosphatase using poly (3, 4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), gold nanoparticles (AuNPs), and Ag+. Signal amplification was achieved by the modification of PEDOT:PSS and AuNPs on glassy carbon electrodes. Atomic force microscopy was performed to characterize the morphology of the modified nanomaterials. To detect ALP, 1-naphthyl phosphate (1-NP) was used as the substrate, and alkaline phosphatase catalyzed 1-NP into 1-naphthol (1-N), which resulted in the reduction of Ag+ to Ag0 on the surface of the modified electrode (AuNPs/PEDOT:PSS/GCE). The deposition of Ag drastically enhanced the detection signal. Differential pulse voltammograms of 1-N, which is the enzymatic product from the ALP reaction with 1-NP, were recorded. In the linear range of 0.1–120 U L−1, a quantitative analysis of alkaline phosphatase was achieved, with high sensitivity and a low detection limit of 0.03 U L−1. Stable, selective, and reproducible electrochemical sensors were designed. Moreover, the proposed electrochemical sensor exhibited a prominent sensing performance in the spiked diluted human serum. Thus, the sensor can be used in numerous applications in alkaline phosphatase or other analyte detection. Full article
(This article belongs to the Special Issue Fluorescent Nanomaterials for Sensing, Bioimaging, and Therapy)
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9 pages, 2862 KiB  
Article
Construction of Effective Nanosensor by Combining Semiconducting Polymer Dots with Diphenylcarbazide for Specific Recognition of Trace Cr (VI) Ion in Water and Vitro
by Xilin Dou, Quan Wang, Tao Zhu, Zhaoyang Ding and Jing Xie
Nanomaterials 2022, 12(15), 2663; https://doi.org/10.3390/nano12152663 - 3 Aug 2022
Cited by 4 | Viewed by 1907
Abstract
Hexavalent chromium (Cr (VI)) ion, as highly toxic environmental pollution, severely endangers the ecological environment and public health. Herein, a fluorescent nanosensor (PFO-DPC) was constructed by combining semiconducting polymer dots with diphenylcarbazide (DPC) for sensing Cr (VI) ion in aqueous solution and living [...] Read more.
Hexavalent chromium (Cr (VI)) ion, as highly toxic environmental pollution, severely endangers the ecological environment and public health. Herein, a fluorescent nanosensor (PFO-DPC) was constructed by combining semiconducting polymer dots with diphenylcarbazide (DPC) for sensing Cr (VI) ion in aqueous solution and living cells. DPC and poly (styrene-co-maleic anhydride) (PSMA) polymer mixed with polyfluorene (PFO) were utilized for selectively indicating Cr (VI) ion and improving the efficiency of detection, respectively. The presence of Cr (VI) ion effectively turned off the blue and green fluorescence of PFO-DPC in the aqueous environment, and the fluorescence quenching efficiency exhibited a good linear relationship between the range of 0.0 to 2.31 nM (R2 = 0.983) with a limit of detection (LOD) of 0.16 nM. The mechanism of fluorescence quenching could possibly be attributed to the internal filtration effect (IFE). Additionally, PFO-DPC showed a satisfactory performance in monitoring intracellular Cr (VI) ion. Our results indicate that the sensor is promising in various applications. Full article
(This article belongs to the Special Issue Fluorescent Nanomaterials for Sensing, Bioimaging, and Therapy)
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